Síndrome de SWEET. A propósito de 1 caso / SWEET syndrome. About 1 case

El Síndrome de Sweet llamado también dermatosis neutrofílica febril aguda es una enfermedad rara, de naturaleza inflamatoria, caracterizada por fiebre de inicio agudo, neutrofilia, lesiones cutáneas eritematosas y dolorosas, infiltrado típico de neutrófilos en la dermis superior y rápida mejoría con corticoesteroides sistémicos. Presenta formas típicas y atípicas, las primeras cumplen con todos los criterios de diagnóstico y las causas pueden ser neoplásica, infecciosa, fármacos, embarazo y a veces idiopática. Se presenta un caso de Síndrome de Sweet típico en una mujer, probablemente desencadenado por un cuadro infeccioso de vías aéreas superiores con confirmación histológica y buena respuesta a la corticoterapia, con remisión total y sin recidiva a la fecha

Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare, inflammatory disease characterized by acute-onset fever, neutrophilia, erythematous and painful skin lesions, a typical neutrophil infiltrate in the upper dermis, and rapid improvement with systemic corticosteroids. It presents typical and atypical forms, the former meet all diagnostic criteria and the causes can be neoplastic, infectious, drugs, pregnancy, and sometimes idiopathic. We present a case of typical Sweet syndrome in a woman, probably triggered by an infectious picture of the upper airways with histological confirmation and good response to corticosteroid therapy, with total remission and no recurrence to date

Síndrome de Sweet en una niña preescolar / Sweet syndrome in a 5-year-old girl

El síndrome de Sweet, también conocido como dermatosis neutrofílica febril, es un trastorno dermatológico poco frecuente en pediatría. Clínicamente, se caracteriza por la aparición de lesiones papulares y/o nodulares de una coloración rojiza-violeta con hipersensibilidad local. Se reporta el caso de una paciente femenina de 5 años, quien consultó por un cuadro clínico de 10 días de evolución de aparición de lesión forunculosa en el arco nasal. Se realizó una biopsia de piel, que reportó dermatitis difusa con predominio de polimorfonucleares neutrófilos, necrosis epidérmica y ausencia de vasculitis. No se identificaron microorganismos. Se consideró el cuadro compatible con síndrome de Sweet. Es importante tener en cuenta este diagnóstico en cuadros clínicos similares y se deben descartar otros diagnósticos más frecuentes primero.

Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is an infrequent dermatological disorder in pediatrics. Clinically it is characterized by the development of papular and/or nodular lesions of a reddish-violet coloration with local hypersensitivity. We report the case of a 5-year-old female who consulted 1 month after the appearance of the lesion in the nasal arch. A skin biopsy was performed and it reported diffuse dermatitis with a predominance of neutrophil polymorphonuclear cells, epidermal necrosis and absence of vasculitis. No microorganisms were identified. It was considered compatible with Sweet syndrome. It is important to consider this diagnosis in similar clinical cases and other more frequent diagnoses must be ruled out first.

Sweet's Syndrome Associated with Graves' Disease

Sweet's syndrome, or acute febrile neutrophilic dermatosis, occurs in association with autoimmune diseases such as Hashimoto's thyroiditis but is rare in Graves' disease, in which all cases are induced by propylthiouracil (PTU). We report a case of Sweet's syndrome in a patient with Graves' disease treated with methimazole (MMI) during three weeks. A 34-year-old man presented with the acute onset of high fever, skin rashes on the whole body, arthralgia, and acroparesthesia. Laboratory results showed leukocytosis and elevated C-reactive protein. MMI first stopped and antibiotics and antihistamine therapy started, but his symptoms dramatically improved after oral prednisolone. Graves' disease has again been treated by MMI because of his aggravated ophthalmopathy. After one year of retreatment with MMI, there has been no recurrence of Sweet's syndrome, supporting that Sweet's syndrome in this case was not related to MMI exposure. To our knowledge, this is the first report of Sweet's syndrome associated with Graves' disease per se but not PTU or MMI use.

Síndrome de Sweet y embarazo: a propósito de un caso / Sweet syndrome and pregnancy: case report

El síndrome de Sweet, también conocido como dermatosis neutrofílica febril aguda, es una entidad infrecuente, de etiología desconocida, caracterizada por la aparición brusca de placas eritematosas, dolorosas, acompañadas de fiebre, leucocitosis neutrofílica y denso infiltrado dérmico leucocitario polimorfonuclear. Si bien la mayoría de los casos son idiopáticos, es bienconocida su relación con procesos neoplásicos malignos, enfermedades autoinmunes, inflamatorias, infecciosas, fármacos y embarazo. Presentamos el caso de una paciente con síndrome de Sweet asociado a embarazo y realizamos una revisión bibliográfica de esta patología.

Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, is a rare entity of unknown etiology characterized by the sudden onset of painful erythematous plaques, associated with fever, leukocytosis with neutrophilia as well as a dense dermal polymorphonuclear leukocytic infiltrate. Although most cases are idiopathic, it is well known to be related with malignant neoplastic processes, autoimmune, inflammatory, infectious diseases, drugs and pregnancy. A case of a pregnant woman with Sweet ́s syndrome diagnosis is reported and a literature review is performed.

Síndrome de Sweet / Sweet syndrome

A síndrome de Sweet, também conhecida como dermatose neutrofílica febril aguda, caracteriza-se pelo aparecimento de pápulas e/ou placas eritematosas dolorosas, muitas vezes em surtos que duram cerca de duas semanas ou mais. Foram revisados características clínicas, achados laboratoriais, doenças associadas, histopatologia e opções de tratamento da síndrome, assim como sua manifestação em crianças.

Localized Sweet's Syndrome in an Irradiated Field

Sweet's syndrome is a reactive dermatosis characterized clinically by fever, leukocytosis, and multiple, erythematous, painful plaques. Histopathologic examination reveals a band-like dense dermal inflammatory infiltrate composed mainly of neutrophils with papillary dermal edema, and no features of vasculitis. We report a case of a 56-year-old female diagnosed with cervical cancer, who underwent surgery and concurrent chemoradiation therapy. Approximately 3 years after completing treatment, she presented with erythematous plaques, principally within the radiation field; the skin biopsy showed features consistent with Sweet's syndrome.

Síndrome de Sweet asociado a carcinoma de mama / Sweet`s Syndrome associated with breast carcinoma

El síndrome de Sweet es una entidad infrecuente definida como una dermatosis neutrofílica febril aguda. Puede asociarse a diferentes patologías, entre ellas,aunque escasamente, a tumores sólidos. Describimos un caso de síndrome de Sweet asociado a carcinoma de mama. Enfatizamos las características distintivas que presenta el síndrome de Sweet cuando se asocia a malignidad. Se realiza una revisión de esta asociación en la literatura nacional.

Sweet´s Syndrome is an uncommon entity defined as acute febrile neutrophilic dermatosis. This syndrome can be associated with different diseases, among them and in few cases, solid tumors. We describe a case of Sweet´s syndrome associated withbreast carcinoma. We emphasize the distinctives clues of Sweet´s syndrome in the context of malignancy. A review of this association in the national literature is done.

Neutrophilic Myositis without Cutaneous Involvement as the First Manifestation of Acute Myeloid Leukemia

Muscle involvement in acute febrile neutrophilic dermatosis is uncommon. Herein, we report a case of acute febrile neutrophilic myositis, without cutaneous involvement, as the first manifestation of acute myeloid leukemia. The patient was a 35-year-old male, referred due to painful swelling of the left upper arm and fever. The overlying skin looked normal, and a muscle biopsy revealed dense infiltrates, predominantly composed of mature neutrophils, edema and tissue necrosis. All culture reports were negative, and he was finally diagnosed as having acute febrile neutrophilic myositis, associated with acute myeloid leukemia. Corticosteroid treatment resulted in the progressive regression of the fever, myalgia and swelling.

A Case of Acute FEbrile Neutrophilic Dermatosis Following Multiple Keratoacanthoma / 대한피부과학회지

Severe recurrent attacks of acute febrile neutrophilic dermatosis shortly followed multiple keratoacanthoma in a 43-year-old man with myelodysplastic syndrome. Besides the typical clinicopathological findings of the syndrome(fever, leukocytosis and neutrophilic erythematous plaques of the skin), the patient showed orolingual and conjunctival ulceration and severe cutaneous pathergic reactions. Moreover, to the best of our knowledge, multiple keratoacanthoma has not yet been reported with relation to the acute febrile neutrophilic dermatosis.

A Case of A cute Fevrile Neutrophilic Dermatosis / 대한피부과학회지

A 36-year-old man has suffered from multiple, well defined, variable sized, and elevated papulonodular patches with oozing, scale, and crust on the face. He also presented multiple folliculitis-like eruptions on upper chest, back, and both limbs. He had no leukocytosis, but elevated ESR and fever during development of skin lesions. Histologically a dense iaflammatory cell infiltra,tion composed predominantly of polymorphonuclear neutrophils and few lymphoid cells were seen in the dermis and subcutis. The symptoms and signs did not spond to dapsone and tetracycline, but disappeared on orally administered predniselone.