Résumé
Objective To investigate the relationship between adiponectin /leptin ratio and metabolic index in type 2 diabetes mellitus .Methods A total of 167 cases of type 2 diabetes in our hospital endocrinology clinic 59 people from January 2013 to 2014 were enrolled in the study ,all patients were divided into three groups accordius to fasting plasma glucose(FPG)(42 people 9 .4mmol/L as Group 3) .Patients who have been excluded from treatment with insulin or insulin .Requiring patients to 10 - 12 hours of fasting ,taken fasting blood samples and samples will be sent to the hospital clinical laboratory measured by biochemical analysis way ,the patient of glycosylated hemoglobin ,fasting blood glucose ,blood lipid indexes for comprehensive testing and calculation of patient related indexes ,and carries on the analysis .Results the patient′s body mass index(BMI) ,fasting insulin (FINS) ,low‐density lipoprotein cholesterol(LDL) ,triglyceride(TG) ,leptin and adiponectin ,between the ages of no statistical significance exists ,male patients with adiponectin levels and TG ,BMI ,HDL and LDL has a relatively close relationship (positive ,P=0 .000 3) leptin levels and BMI was negatively correlated (P<0 .05) .The adi‐ponectin levels of female patients were closely related to TG ,LDL and HD (positive correlation ,P<0 .05) .Leptin levels and TG were associated with BMI (negative correlation) ,and A/L ratio was correlated with all the indexes (negative correlation) in male and female patients (P<0 .05) .Conclusion HOMA‐IR can not be used as an important indicator of insulin resistance ..A/L and it are more suitable for .
Résumé
BACKGROUND: We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults. METHODS: Sixty-eight male subjects were enrolled among the participants of an annual health check-up program (mean age, 55.1 years). Percent body fat (%) was measured using a bioelectric impedance analyzer. Serum leptin level was measured via radioimmunoassay, and adiponectin level was measured using an enzyme-linked immunosorbent assay. Homeostasis model assessment (HOMA)-insulin resistance (IR) index was calculated, and the presence of metabolic syndrome was assessed. RESULTS: Adiponectin, leptin, and A/L ratio showed significant correlations with percent body fat, lipid profile, and HOMA-IR. Mean leptin and HOMA-IR levels were significantly higher, while A/L ratio was significantly lower in subjects with MS. With increasing number of MS components, the mean values of leptin and HOMA-IR increased and the A/L ratio decreased. In multiple regression analysis, HOMA-IR was significantly correlated with triglyceride, fasting glucose, and A/L ratio, while A/L ratio was significantly correlated with body mass index and HOMA-IR. HOMA-IR and A/L ratio were significant predictors for each other after adjustment for other factors. CONCLUSION: A/L ratio correlated well with lipid profile, HOMA-IR, and the presence and number of MS components in Korean male subjects.