Résumé
Objective: To study the changes in coagulation function in patients with advanced tumors before and after vascular interventional therapy. Methods: A total of 174 patients with middle-late stage tumors undergoing oncology vascular interventional treatment at Beijing Hospital Of Traditional Chinese Medicine Affiliated With Capital Medical University, between January 2018 and October 2018 were included in this retrospective analysis. Changes in platelets (PLT) and related blood coagulation indicators were observed before and after vascular intervention. Among them, 63 patients who received relevant indicators detection within a week after vascular intervention were in group A, and 111 patients who received relevant indicators detection 1 month (30±7 days) after vascular intervention were in group B. SPSS version 22 software was used for statistical analysis. Results: In group A, fibrinogen (FIB) and D-dimer (D-D) values significantly increased, activated pattial thromboplastin timeAPITshortened, and PLT values decreased compared to those before treatment (all P0.05) than those before treatment. Before vascular interventional therapy, a total of 58 patients had hypercoagulability, including 28 patients in group A (48.3%) and 30 patients in group B (51.7%). In contrast, after vascular interventional therapy, a total of 71 (40.8%) patients had hypercoagulability, including 40 (56.3%) patients in group A and 31 (43.7%) patients in group B. Conclusions: Vascular interventional treatment can affect the related blood clotting index in the short term, which is intensified in patients with middle-late tumors and a high blood coagulation state. However, over time the coagulation state gradually mitigated and eventually returned to before-treatment levels. These findings suggest that patients' coagulation function should be closely monitored after intervention treatment.
Résumé
Objective To investigate the therapeutic mechanism of ~(125)I seeds based on physical properties, the significance of therapeutic planning system (TPS), the therapeutic means and the clinical efficacy. Methods Eighteen cases with advanced carcinoma were treated through percutaneous implantation of 125 I for interstitial radiotherapy. Results No serious complications occurred in the patients after radiotherapy associated with apparent improved living quality. Two months after therapy, the tumors had shrunk in different degrees with conspicuous decrease in 12, of which 5 tumors disappeared. Conclusions Short-term efficacy demonstrates that intra-tissue radiotherapy of ~(125)I had significant efficacy for advanced tumors.