Résumé
Objective To evaluate the clinical significance of aluminum phosphate gel in the early preven-tion of gastrointestinal reactions caused by erythromycin , in order to obtain better clinical treatment for children. Methods The clinical data of 110 children with Mycoplasma pneumonia from January 1,2015 to December 31,2016 in the pediatric ward of Anhui Provincial Hospital were collected.According to the treatment methods ,the patients were divided into the observation group (60 cases) and the control group (50 cases).The observation group was mainly treated with erythromycin combined with aluminum phosphate gel ,some of which were given cephalosporin anti-infection,montelustra sodium to reduce airway hyperreaction ,hormone antiasthmatic,atomization inhalation and other supportive symptomatic treatment.The control group was mainly treated with erythromycin ,some of which were given cephalosporin anti-infection,montelustra sodium to reduce airway hyperreaction ,hormone antiasthmatic,atomi-zation inhalation and other supportive symptomatic treatment.The age,body weight,pre-hospital course,white blood cell count(WBC),CRP,alanine aminotransferase (ALT),creatinine(Cr),urea nitrogen (BUN),length of stay,sex, montruster sodium granules ,atomization,antibiotics, hormone use and gastrointestinal adverse reactions ( abdominal pain,vomiting, nausea, diarrhea, inappetence ) were compared between the two groups.Results A total of 110 children were selected,60 cases in the treatment groups ,including 38 males and 22 females,and the average age of children was (6.21 ± 2.26 ) years old.In the control group, there were 50 cases, including 23 males and 27 females,with an average age of (6.07 ±2.61)years.The age,weight,pre-hospital course,WBC,CRP,ALT,Cr, BUN,days of hospitalization ,etc.between the two groups had no statistically significant differences ( all P＞0.05). There were no statistically signifiant differences between the two groups in terms of sex ,montruster sodium particles, atomization,antibiotics,hormone use,etc.( all P＞0.05).The differences of abdominal pain ,vomiting,nausea and diarrhea between the two groups were not statistically significant (all P＞0.05).However,the difference of inappe-tence between the two groups was statistically significant ( P ＜0.05).The incidence rate of gastrointestinal side effects(abdominal pain,vomiting,nausea,diarrhea,inappetence ) of the observation group was 18.3 %(11／60 ), which of the control group was 48.0%(24／50),the difference was statistically significant between the two groups (χ2 ＝11.064,P＜0.05).Conclusion Aluminum phosphate gel can prevent gastrointestinal reactions induced by erythromycin in the treatment of Mycoplasma pneumonia ,so that children get better treatment.
Résumé
Objective@#To evaluate the clinical significance of aluminum phosphate gel in the early prevention of gastrointestinal reactions caused by erythromycin, in order to obtain better clinical treatment for children.@*Methods@#The clinical data of 110 children with Mycoplasma pneumonia from January 1, 2015 to December 31, 2016 in the pediatric ward of Anhui Provincial Hospital were collected.According to the treatment methods, the patients were divided into the observation group(60 cases) and the control group(50 cases). The observation group was mainly treated with erythromycin combined with aluminum phosphate gel, some of which were given cephalosporin anti-infection, montelustra sodium to reduce airway hyperreaction, hormone antiasthmatic, atomization inhalation and other supportive symptomatic treatment.The control group was mainly treated with erythromycin, some of which were given cephalosporin anti-infection, montelustra sodium to reduce airway hyperreaction, hormone antiasthmatic, atomization inhalation and other supportive symptomatic treatment.The age, body weight, pre-hospital course, white blood cell count(WBC), CRP, alanine aminotransferase(ALT), creatinine(Cr), urea nitrogen(BUN), length of stay, sex, montruster sodium granules, atomization, antibiotics, hormone use and gastrointestinal adverse reactions(abdominal pain, vomiting, nausea, diarrhea, inappetence) were compared between the two groups.@*Results@#A total of 110 children were selected, 60 cases in the treatment groups, including 38 males and 22 females, and the average age of children was (6.21 ± 2.26)years old.In the control group, there were 50 cases, including 23 males and 27 females, with an average age of (6.07 ± 2.61)years.The age, weight, pre-hospital course, WBC, CRP, ALT, Cr, BUN, days of hospitalization, etc.between the two groups had no statistically significant differences (all P>0.05). There were no statistically signifiant differences between the two groups in terms of sex, montruster sodium particles, atomization, antibiotics, hormone use, etc.(all P>0.05). The differences of abdominal pain, vomiting, nausea and diarrhea between the two groups were not statistically significant (all P>0.05). However, the difference of inappetence between the two groups was statistically significant (P<0.05). The incidence rate of gastrointestinal side effects(abdominal pain, vomiting, nausea, diarrhea, inappetence) of the observation group was 18.3 %(11/60), which of the control group was 48.0%(24/50), the difference was statistically significant between the two groups (χ2=11.064, P<0.05).@*Conclusion@#Aluminum phosphate gel can prevent gastrointestinal reactions induced by erythromycin in the treatment of Mycoplasma pneumonia, so that children get better treatment.
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Objective To study curative efficacy of aluminum phosphate gel combined with omeprazole in treatment of peptic ulcer and its effects on Gas, TGF-αlevels.Methods 80 patients of peptic ulcer who received therapy from April 2015 to April 2016 in our hospital were selected as research objects.According to random number table, those patients were divided into the observation group and the control group, 49 patients in each group.the control group was treated with omeprazole, while the observation group was treated with aluminum phosphate gel combined on the basis of control group.Then Transforming growth factor, adverse reaction and curative effect were compared.Results After treatment, the serum levels of Gas and TGF-αin both groups were improved (P<0.05); Two weeks after treatment,the level of GAS in the observation group were lower than those in the control group(P<0.05), TGF-αlevel was higher than that in control group(P<0.05); The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05); The total effective rate in the observation group was higher than that in the control group(P<0.05). Conclusion Combined use of aluminum phosphate gel and omeprazole in the treatment of peptic ulcer can effectively improve the patient-related serum markers, improve the quality of ulcer healing, significant efficacy, high safety and low incidence of adverse reactions.
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AIM:To observe the preventive effects of aluminum phosphate gel and smectite powder on the side effects of erythromycin lactobionate via intervenous drop infusion for the gastrointestinal tract in children.METHODS:249 cases children with mycoplasmal pneumonia were randomly divided into three groups,aluminum phosphate gel group,smectite powder group and control group,83 cases in each group.The side effects of erythromycin lactobionate(abdominal pain,diarrhea,sicchasia,disgorging)for the gastrointestinal tract among three groups were observed.RESULTS:Compared with control group,the incidence rate of side effects was much lower in aluminum phosphate gel group and smectite powder group(P0.05).CONCLUSION:Aluminum phosphate gel and smectite powder significantly decrease the side effects of erythromycin lactobionate for the gastrointestinal tract in children,and especially the former,can be widely applied in pediatric clinic.