RÉSUMÉ
Background: Cancer incidence is increasing annually in all countries. So, it is nowadays a great burden for the different nations of the world. Research for new therapeutics is becoming an urgent need, particularly for intractable and chemoresistant cancer cases. The solutions can still be found by investigating natural products which are recognized as promising sources of bioactive compounds with a potential for the discovery of new preventive and therapeutic anticancer agents. Methodology: The present work used databases such as Pubmed, Science Direct and Google scholar to investigate the ethnobotanical uses of some Combretum species in the literature. It also allowed us to summarize some pharmacological studies on Combretum species. Results: This review gathers all available traditional uses and cytotoxicity studies of Combretum species in the literature. Special focus is given to pharmacological studies highlighting isolated potential anticancer molecules. These molecules present potent cytotoxic effect on various cancer cell lines and may contribute to improving the health of people suffering from various cancer diseases. Conclusion: The Combretum species are widely used in folk medicine for the treatment of several pathologies including cancers. This study is of fundamental importance in highlighting Combretum species as a potential source for research of new anticancer compounds.
RÉSUMÉ
Nyctanthes arbor-tristis (Oleaceae) popularly known as “Parijat” is a plant of great importance in India. It iswidely used in Ayurvedic medicines. Each part of this plant has some medicinal value. It possesses extensivemedicinal uses, viz., antipyretic, anti-inflammatory, anthelmintic, sedative effect, laxative, and expectorant, inrheumatism. The present review aims to perform a detailed compilation of work done on this plant mainly asa source of the antioxidant and anticancer agent as well as various pharmacological properties from 1987 totill date. All these activities possessed by plants are due to the presence of multiple phytochemicals which canact as a source of active pharmacological agents. Crude extracts, as well as pure compounds like 4-hydroxyhexahydrobenzofuran-7-one, 6β-hydroxyloganin, and Arbortristoside A from seeds, a polysaccharide fromleaves, and Naringenin from the stem, are reported for its anticancer and antioxidant properties. The need ofthe hour is to provide scientific validation of ethnomedicinal use of this plant. The present study can be usedto highlight the need for research and potential development of natural therapeutic products with lesser sideeffects.
RÉSUMÉ
A series of new aminomethyl derivatives of methyl-substituted asymmetrical curcumin mono-carbonyl was synthesizedand evaluated for their anticancer potential by means of cytotoxicity and selectivity determination against MCF-7,WiDr, Hela, A549, PLC/PRF/5, and Chang Liver cells lines using the methyl thiazolyl tetrazolium proliferation assaymethod. All the synthesized compounds (3a–f) exhibited high cytotoxic against WiDr cells lines, but only 3a–e hadhigh cytotoxic against MCF-7 cells lines, and only 3b showed high cytotoxic against HeLa, A549, and PLC/PRF/5 celllines. However, 3b and 3c exhibited high cytotoxic against Chang Liver (normal liver) cells lines. Further evaluationsshowed that compounds 3d, 3e, and 3f exhibited a potent and selective cytotoxic agent (IC50 = 5.70, 5.55, and 2.97µM) against WiDr (colorectal carcinoma) cells lines with selectivity index (SI) = 4.43, 2.69, and 2.04, respectively.The compounds performed better cytotoxic activity than curcumin and 5-fluorouracil (IC50 = 8.29 and >100 µM andSI = 1.28 and <1). So, compounds 3d, 3e, and 3f were potential as an anticancer agent for colorectal carcinoma andshould be further studied for investigating their mechanism of action and their effectivity in preclinical studies usingan animal model..
RÉSUMÉ
Studies of extracts and phytochemicals from Passiflora genus have shown promissory biological activity for cancerchemoprevention; thus, in this work, it was evaluated the anticancer potential of the ethanolic extract of Passifloraedulis f. Flavicarpa leaves over Caco-2 and SW480 colorectal adenocarcinoma cells. The effect of the extract oncell viability was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and its antiproliferativeactivity was assessed by clonogenic assays. In addition, by flow cytometry approaches, it was evaluated the apoptosisinducing effect and cell cycle regulation. In this way, it was established the half maximal inhibitory concentration(IC50) of the extract over both cell lines and also, it was observed the inhibition of cellular proliferation after 48 hoursof exposure to the extract. On the other hand, we observed that the extract induced cell death-mechanisms, by theincreasing of the proportion of necrotic and apoptotic cells; furthermore, the extract altered the distribution of cellcycle phases by increasing SubG1 and G2/M populations. Altogether, these results suggest that P. edulis is a potentialsource of phytochemical compounds with anticancer properties for the management of colorectal cancer patients.