Aging Change of Pupil Size in Normal and Diabetic Patients

It is well recognized that diabetic patients have small pupil. The most likely cause of the abnormally small pupil in diabetics is decreased funcitor of the autonomic nerves. We measured pupil size in 141 control subjects and 53 diabetic patients (29 cases with symptomatic autonomic neuropathy, 24 cases without symptomatic autonomic neuropathy) with portable pupillometry, PUPILSCAN in darkness. Pupils become smaller in healthy and diabetic subjects with advancing age. (log pupil size = 2.05 - 0.066 X age, r: -0.47, p