RÉSUMÉ
The key assessment of the study was evaluating the gastro-protective properties of Barleria buxifolia root extract (REBB) in ulcerative rats. The roots of Barleria buxifolia have properties like antioxidant, anti-inflammatory, and other health benefits. Induction of gastric ulcers was done with aspirin (150 mg/kg, b.w., p.o) for 3 days and was accompanied by treatment with REBB (200 & 400 mg/kg orally) for 15 days. Ranitidine (20 mg/kg, orally) was received as the standard treatment for 14 days. Ulcer index, percent inhibition of ulceration, lipid peroxidation (LPO), TNF-? levels, and histopathological examination of the gastric mucosa were measured. Aspirin-induced stomach ulcers were seen in 100% of the groups, whereas other animal groups, aside from the control group possessed relatively comparable inductions. Ulcer number, ulcer index (p<0.01), and LPO (p<0.05) shown significant reduction in the 400mg/kg and Ranitidine (20mg/kg) when compared to Aspirin induced control group. Whereas the Ulcer score (p<0.001) and TNF-? (p<0.05) showed significant reduction in Ranitidine treated group but showed objectively improvement but statistically non-significant results in 200mg/kg and 400mg/kg REBB. Hence it was found that Baleria buxifolia root extract effectively mitigates aspirin-induced gastric ulceration in rats, underscoring its potential as a gastro protective agent.