Résumé
Retinitis pigmentosa (RP) is a hereditary ocular disease that can cause blindness.There is no effective treatment currently.Although new technologies,such as gene therapy,stem cell therapy,photogenetics and retinal prostheses have flourished in recent years,they have not been widely applied in clinical practice in the near future.Classical pharmacological treatment is the only choice for now.Although the mechanism of RP is not completely clear,researches have found that,photoreceptors apoptosis is the final common pathway in RP.Excessive inflammatory response,oxidative stress can influence RP process and cause retina degradation,and lack of neurotrophic factors and phototransduction associated molecules may also lead to RP exacerbation.According to the common pathological pathways of RP,pharmacological treatment can play its role widely and universally in different genotypes of RP on the above stages.This review provides an overview of the current basic researches of drug treatment from different respects,including anti-photoreceptors apoptosis,anti-inflammatory,anti-oxidation and neuro protection.
Résumé
Sanhuang Xiexin Decoction is one of the ancient decoctions, which has thousands years of history and has been still used nowadays. It is widely used in the diseases which are caused by exuberant fire in clinicl. Sanhuang Tablets and Yiqing Granules which are derived from Sanhuang Xiexin Decoction have become standing drugs in Chinese families. This paper reviewed the research reports on Sanhuang Xiexin Decoction for recent 50 years, analyzed the researching characteristics and superiorities of Sanhuang Xiexin Decoction, and found out the key links and core problems. The aim of this paper is to provide the references for the research of modernization and development of Sanhuang Xiexin Decoction.