Effect evaluation of online lifestyle intervention on women with infertility and central obesity / 预防医学

Objective@#To evaluate the effect of online lifestyle intervention based on cognitive behavior adjustment on the female patients with infertility and central obesity. @*Methods@#From November 2019 to November 2020, the women with infertility and central obesity in the Reproductive Medicine Center of Zhejiang Provincial People's Hospital were recruited and divided into two groups. The intervention group received online lifestyle intervention based on cognitive behavior adjustment for twelve weeks, and the control group received routine health education. Body weight, waist circumference, fasting blood glucose, fasting insulin, insulin resistance index (HOMA-IR), body fat, the pregnancy rate and the abortion rate were compared between the two groups. @*Results@#There were 78 cases each in the intervention group and the control group, aged (31.15±4.87) years and (31.17±4.81) years, respectively. There were no significant differences between the two groups in age, body weight, body mass index, waist circumference, waist-hip ratio, fasting blood glucose, fasting insulin, HOMA-IR and body fat percentage before intervention (all P>0.05). After twelve-week intervention, the results of mixed effect model showed that the decrease of waist circumference, fasting insulin and body fat percentage in the intervention group were greater than those in the control group (all P<0.05). After six-month follow-up, there was no significant differences in the pregnancy rate (33.33% vs. 23.08%) and the abortion rate (7.69% vs. 16.67%) between the two groups (both P>0.05). @*Conclusion@#Online lifestyle intervention based on cognitive behavior adjustment helps to control central obesity and hyperinsulinemia.

Intervention Effect of Repetitive TMS on Behavioral Adjustment After Error Commission in Long-Term Methamphetamine Addicts: Evidence From a Two-Choice Oddball Task / 神经科学通报·英文版

Behavioral adjustment plays an important role in the treatment and relapse of drug addiction. Nonetheless, few studies have examined behavioral adjustment and its plasticity following error commission in methamphetamine (METH) dependence, which is detrimental to human health. Thus, we investigated the behavioral adjustment performance following error commission in long-term METH addicts and how it varied with the application of repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC). Twenty-nine male long-term METH addicts (for > 3 years) were randomly assigned to high-frequency (10 Hz, n = 15) or sham (n = 14) rTMS of the left DLPFC during a two-choice oddball task. Twenty-six age-matched, healthy male adults participated in the two-choice oddball task pretest to establish normal performance for comparison. The results showed that 10 Hz rTMS over the left DLPFC significantly decreased the post-error slowing effect in response times of METH addicts. In addition, the 10 Hz rTMS intervention remarkably reduced the reaction times during post-error trials but not post-correct trials. While the 10 Hz rTMS group showed a more pronounced post-error slowing effect than the healthy participants during the pretest, the post-error slowing effect in the posttest of this sample was similar to that in the healthy participants. These results suggest that high-frequency rTMS over the left DLPFC is a useful protocol for the improvement of behavioral adjustment after error commission in long-term METH addicts.

Efectos en la dsstribución temporal de la respusta as0ciados a la variación enn la probabilidad de entrega de agua en programas señalados: análisis del tipo de contacto y ajuste a relaciones de contingencia tempoaal / Effects n temporral distribution of response associated with the variation in the probability of water deliverty using stimuli-correlated temporal schedules: analysis of the type of contact and adjustment to temporal contingency relations

Se evaluaron los efectos de manipular los valores de P en la distribución temporal del responder bajo programas temporales. Se utilizaron 6 ratas albinas experimen-talmente ingenuas las cuales se dividieron en dos grupos. Cada uno de los grupos se expuso a un programa temporal de distinta longitud. El Grupo 1 T= 30 s., el Grupo 2 T=120". Cada grupo se expuso a cuatro fases distintas. El parámetro P se manipuló entre fases en los valores de 1.0, 0.5 y 0.1. Durante las fases experimentales se entregó agua de manera contingente al responder de las ratas de acuerdo al valor de P. En las primeras tres fases se señalizaron de manera diferencial los subintervalos de ∂t y Δt. Durante la fase cuatro (redeterminación de P a 1.0), la señalización se eliminó en ambos subintervalos. Posterior a las fases experimentales las ratas se sometieron a sesiones de sondeo en las cuales la entrega de agua fue independiente al responder. En la medida que los programas temporales prescriben contingencias temporales respecto de las ocurrencias de respuestas y eventos de estímulo, los resultados se analizan en términos de la modulación de las propiedades temporales de dichos eventos. En este sentido, se evidenciaron diferencias en la distribución temporal de las respuestas efectivas e inefectivas bajo condiciones de señalización y no señalización. Se analizan los resultados en términos del tipo de ajuste a las contingencias de ocurrencia característica de los programas definidos temporalmente, además se sugiere que los programas definidos temporalmente representan una herramienta metodológica pertinente para el análisis de las funciones contextual y suplementaria sugeridas por Ribes y López (1985).

One study was conducted to evaluate the effects of manipulating the values of P on performance under temporal defined schedules. It was used 6 experimentally naive albino rats that were divided into two groups. Each group was exposed to a temporal defined schedule with different cycle length. Group 1 was T = 30 s. and Group 2 was T = 120 s. Each group was exposed to four distinct experimental phases. The parameter P was manipulated between phases with the values of 1.0, 0.5 and 0.1. The first three phases the subintervals ∂t and Δt were signaled differentially. During the phase fourth (redetermination), signaling was eliminated in both subintervals. The results suggest that the T-cycle length determines the response patterns. In addition, differences were observed in temporal properties of effective and ineffective responses under signaling and no signaling conditions. The results were analyzed in terms of type of the behavioral adjustment to occurring contingencies featured into temporal defined schedules. We suggest that this procedure represent a relevant methodological tool for analyzing the contextual and supplementary functions suggested by Ribes and Lopez (1985).