Botulinum neurotoxin a for hand tremors in Parkinson’s disease: A meta-analytic study

Background@#Resting tremor is a prominent cardinal motor symptom of Parkinson’s disease (PD). In some cases, the tremor may be refractory to dopaminergic and anticholinergic treatment. Multiple studies were previously done to evaluate the effectiveness of Botulinum Neurotoxin A (BoNT/A) with essential tremors and dystonia, but data regarding its use on tremors of PD is still lacking. @*Objective@#This meta-analytic study aims to determine the effectiveness of BoNT/A in treating tremors of patients with PD. @*Data Sources@#Data Sources: Researches were searched at PubMed, ScienceDirect and EBSCO Host. @*Review Methods@#Articles on the effect of BoNT/A on PD hand tremors were searched. Studies and data pertaining to non-PD tremors like essential tremors excluded in the analysis due to difference in pathophysiology. Standardized mean difference was used as the effect measure and was computed with Review Manager version 5.4 software. @*Results@#Three open label studies were used for final analysis in this study. Studies included are those pertaining to tremors due to PD. Pooled estimates showed a significant change in decreasing tremor score after BoNT/A injection. @*Conclusion@#Botulinum Toxin A injections can be used to manage PD tremors effectively.

Effect of Early Incision Combined with A Botox on the Recovery of Incision in the Small Area of Facial Scar / 医学研究杂志

Objective To investigate the effect of early incision of botulinum toxin type A (A Botox) on the recovery of the incision in the small area of the opposite side of the incision.Methods Totally 300 cases of facial small area scar surgery were randomly divided into three groups according to the random number table,with 100 cases in each group.The pations of normal group according to the conventional method,the facial scar surgery,after the surgery,clean cut,did not do special treatment.The pations of control group were treated according to the conventional method for facial scar surgery,postoperative cleaning of incision,from postoperative to postoperative 3 months reduction treatment,were treated with 3M free seam tape.The pations of observation group in the same way for facial scar surgery,a local injection of Botox and from postoperative to postoperative 3 months reduction treatnent,were treated with 3M free seam tape.After 3 months and 1 years of follow-up,the condition of scar recovery were evaluated.After 1 years of follow-up,the treatment efficiency was compared.Results Treatment for 3 months,the VSS,OSAS,and PSAS of observation group were 5.2 ± 1.4,14.7 ± 2.4,15.4 ±3.6,were lower than those of the control group and those of the normal group (P ＜ 0.05).One year after treatment,the score of VSS,OSAS,and PSAS of three groups were reduced.Those of observation group were lower than those in the control group and those in the normal group (P ＜ 0.05).The cure rate of observation group was 82％,which was significantly higher than that of the control group 63％and that of the normal group 52％ (P ＜ 0.05).The total effective rate of observation group was 97％,was significantly higher than that of the control group 85％ and that of the normal group 79％ (P ＜ 0.05).Conclusion The method of BotoxA early incision injection combined with the reduction method can effectively promote the small area of facial scar surgery incision recovery effect,improve the cure rate,to meet the needs of patients with facial beauty.