Clinical features and surgical treatment of extrahepatic growing hepatocellular carcinoma / 中国普通外科杂志

Objective To study the clinical characteristics, diagnosis and treatment of extrahepatic growing hepatocellular carcinoma(HCC). Methods The clinical data of 11 patients with extrahepatic growing HCC were analysed retrospectively. Results The mean diameter of the tumors was (12.4?4.3)cm.All the tumors in the 11 patients had complete capsule formation. The numbers of tumors located in the left, right and caudate lobe of the liver were 6,3 and 2 respectively. Surgical treatment included segmentectomy in 6 cases , lobectomy in 4 cases, and unresectable in 1 case. The 1-, 2-, and 3-year survival rates were 80.1%,62.3%, and 47.6% respectively. Conclusions Although the size of extrahepatic growing HCC is large,the resection rate is high and prognosis is good. The resection of hepatic segments or lobes containing the lesion should be done in radical operation of this tumors.

Detection of circulation AFPmRNA and telomerase activity in peripheral blood mononuclear cells of patients with hepatocellular carcinoma / 中国普通外科杂志

Objective To investigate the role of detection of circulation alpha-fetoprotein(AFP) mRNA and telomerase activity in peripheral blood mononuclear cells(PBMC) of patients with hepatocellular carcinoma(HCC).Methods In patients with HCC,benign liver tumors,chronic liver diseases,and healthy volunteers,expression of circulation AFPmRNA and telomerase activity in PBMC were detected using nest reverse transcriptase-PCR(Nest RT-PCR) or PCR-ELISA respectively.Results(1) All the patients with benign liver tumors(n=10),chronic liver diseases(n=30),and healthy volunteers(n=30) had negative expression of circulation AFPmRNA,and the positive rate of circulation AFPmRNA in patients with HCC(73.3%,22/30)(all P

Heptocellular carcinoma with serum AFP level in 21?g/L to 200 ?g/L / 中国普通外科杂志

Objective To introduce clinical diagnostic specificity of hepatocellular carcinoma (HCC) with serum AFP level in 21*!?g/L to 200*!?g/L. Methods Making a literature summarizaton based on the papers review.Results and Conclusions (1) The AFP level more than 20*!?g/L can be used as a diagnostic criteria of HCC when existing liver space occuping lesion (SOL). (2) The clinical diagnostic criteria using AFP level more than 20 ?g/L instead of more than 200 ?g/L would be helpful to avoid misdiagnosis of HCC with the AFP level in 21 ?g/L to 200 ?g/L. (3) The Combination of AFP level more than 20 ?g/L with ultrasonography, CT scanning would have higher sensitivity and specificity than single diagnostic method.