Calcifying cystic odontogenic tumor associated with ameloblastoma – A rare histological variant

Calcifying odontogenic cysts (COCs) represent a heterogeneous group of lesions that exhibits a variety of clinical, behavioral, and histological features. COC or Gorlin's cyst is now classified by the World Health Organization as a tumor. Calcifying cystic odontogenic tumor (CCOT) is an uncommon developmental odontogenic lesion that demonstrates histopathologic diversity. Odontogenic tumors such as ameloblastoma have been reported to be associated with CCOT. In this paper, we report a case of ameloblastomatous CCOT in a 16-year-old girl with involvement of mandibular posterior region, which is an extremely rare histologic variant.

Calcifying cystic odontogenic tumour associated with odontoma involving mixed dentition / Tumor odontogênico cístico calcificante associado a odontoma envolvendo dentição mista

Calcifying cystic odontogenic tumor (CCOT) is a benign tumor relatively uncommon that may be associated with other odontogenic lesions. This manuscript describes the case of a 9-year-old girl affected by CCOT associated with odontoma, presenting as a slight swelling along with prolonged retention of a maxillary primary central incisor. Radiographic examination showed a unilocular radiolucent lesion containing radiopaque material associated with an unerupted tooth. Taking into consideration the clinical diagnostic of odontoma, an excisional biopsy was carried out. Microscopic examination established the diagnosis of a CCOT associated with odontoma. The association of these lesions is rare in individuals in the first decade of life, particularly involving mixed dentition, as outlined in this case. The patient remains under care with no clinical signs of recurrence.

O tumor odontogênico cístico calcificante (TOCC) é um tumor odontogênico cístico benigno relativamente raro e pode estar associado a outras lesões odontogênicas. Este manuscrito descreve um caso de CCOT associado a odontoma em uma menina de 9 anos de idade, que se apresentou com um ligeiro aumento de volume associado a retenção prolongada de um incisivo central superior. O exame radiográfico revelou uma lesão radiolúcida unilocular contendo material radiopaco, associado a um dente incluso. Tomando em consideração o diagnóstico clínico de odontoma, uma biópsia foi realizada. O exame microscópico estabeleceu o diagnóstico de um TOCC associado a odontoma. A associação destas lesões é rara em indivíduos na primeira década de vida, particularmente envolvendo dentição mista, conforme descrito no presente caso. O paciente permanece sob cuidados sem sinais clínicos de recorrência.

Conservative approach to recurrent calcifying cystic odontogenic tumor occupying the maxillary sinus: a case report

Calcifying cystic odontogenic tumor (CCOT) is an uncommon benign cystic neoplasm of the jaw that develops from the odontogenic epithelium. Invasion into the maxillary sinus by a CCOT is not a typical, and the recurrence of the cystic variant of CCOT in the posterior maxilla is rare. This report describes a recurrent CCOT occupying most of the maxillary sinus of a 24-year-old male patient. As a treatment, marsupialization was carried out as a means of decompression, and the involved teeth were all endodontically treated. Afterward, surgical enucleation was performed. The size of the lesion continued to shrink after marsupialization, and the maxillary sinus restored its volume. This patient has been followed-up for 3 years after the surgery, and there have not been any signs of recurrence.

Central Calcifying Cystic Odontogenic Tumor of Mandible - A Case Report.

The calcifying cystic odontogenic tumor (CCOT) is a rare benign odontogenic cystic neoplasm. The terminological conundrum regarding its categorization as a cyst or a tumor has been resolved after the latest WHO classification (2005) that has labelled it as a tumor. The diversity in its morphological patterns, clinical behaviour, histologic complexity and prognosis has led to the practise of multiple management strategies with variable results. This report describes a case of CCOT presenting as a large cystic lesion in theanterior mandible that was managed by enucleation and curettage with a postoperative one year recurrence free follow up. A brief review of literature pertaining to various management strategies of CCOT in comparison with dentinogenic ghost cell tumor (DGCT) is also presented.

Dentinogenic Ghost Cell Tumor: A Case Report and Review of Literature

Ghost Cell Odontogenic Carcinoma Arising from Calcifying Cystic Odontogenic Tumor: A Case Report

Ghost cell odontogenic carcinoma (GCOC) is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. We describe a case of GCOC which was considerably derived from a previously resected calcifying cystic odontogenic tumor (CCOT). Cellular atypia, mitotic activity, Ki-67 labeling index and matrix metalloprotease-9 positive expression rate were all increased in the currently resected specimen compared to the initial one. This is a rare case of malignant transformation of CCOT to GCOC with respect to its histopathological and immunohistochemical findings.

Multicystic Variant of Calcifying Cystic Odontogenic Tumor Associated With Odontome - Report of A Case And Review.

Calcifying cystic odontogenic tumor is an uncommon odontogenic neoplasm which is included in the heterogenous group of lesions under a broader description of Ghost cell odontogenic tumors. All these lesions have the presence of ghost cells as a common feature. Calcifying cystic odontogenic tumor is a unique lesion with variable biologic behaviour and found to occur with other odontogenic tumours. We present a case of Calcifying cystic odontogenic tumor occurring in a 15 year old boy involving an unerupted permanent canine and premolar. The tumor was multicystic in nature and was associated with a complex odontome. This article also includes an update on nomenclature and classification of ghost cell odontogenic lesions.