Concern about the prevention and treatment of parathyroid hyperfunction or hyperparathyroidism associated metastatic vascular calcification or calcinosis universalis / 中华内分泌外科杂志

Metastatic vascular calcification and calcinosis universalis, as severe complications of parathyroid hyperfunction and hyperparathyroidism, have attracted more attention in patients with renal secondary hyperparathyroidism and primary hyperparathyroidism. But, they are of little concern in patients with long-term negative calcium balance related parathyroid hyperfunction or hyperparathyroidism caused by calcium and/or vitamin D insufficiency (CVI). CVI is common in the population. Relatively low level of serum calcium and negative calcium balance caused by long-term CVI result in parathyroid hyperfunction or hyperparathyroidism, which may cause secretion of PTH beyond the physiological level, leading to bone absorption and release of a large amount of bone calcium into the blood. It may not only cause bone loss and osteoporosis, but also form metastatic vascular calcification or calcinosis universalis presented by cardiovascular diseases and other multi-organ lesions. Early calcium deposition can gradually fade after reasonable treatment, but middle arterial calcification is not easy to fade once it occurs. Therefore, vascular calcification and calcium deposition should be actively prevented and early screened and diagnosed. The early prevention, diagnosis and treatment of parathyroid hyperfunction or hyperparathyroidism can prevent, delay, or even reverse the occurrence and development of metastatic vascular calcification and calcinosis universalis, which is significant for disease prevention and protecting the patients' health influenced by these diseases.

Calcinose universal idiopática: apresentação em recém-nascido / Idiopathic calcinosis universalis: infant presentation

A calcinose universal idiopática é uma doença rara, de diagnóstico difícil e que se manifesta em recém-nascidos e crianças. Relatamos o caso de um paciente recém-nascido, do sexo masculino, apresentando calcificação limitada ao tecido subcutâneo do membro superior direito.

The idiopathic calcinosis universalis is a rare disorder of unknown cause which affects infants and children. This article reports on a case of a recent born male patient showing limited calcification inthe subcutaneous tissue of the right upper arm.

A Case of Idiopathic Calcinosis Universalis / 대한피부과학회지

Calcinosis cutis results from deposits of calcium and phosphorus in the skin. Calcinosis cutis may be divided into four major categories: dystrophic, metastatic, idiopathic and iatrogenic. A 19-year-old female presented with multiple brown or skin-colored, stony hard plaques on the face, trunk, arm and thigh for 18 months. She did not have any familial and medical history. None of the laboratory findings, including serum calcium, phosphate and autoantibodies for connective tissue disease, was significant. X-ray examination of bones evidenced multiple reticulated heterotrophic calcifications and whole body bone scan evidenced increased radiotracer uptake according to cutaneous or subcutaneous tissue. This case is compatible with idiopathic calcinosis universalis. Treatment with diltiazem was started.

Childhood Dermatomyositis Associated with Calcinosis Universalis / 대한피부과학회지

We experienced a case of childhood derrnatomyositis associated with calcinosis universalis in a 3-year-old boy. The skin lesion showed generalized, hard nodules and ulcers, 0, 3-1 cm in cliameter, or the trunk and buttock. The hitopathologic findings revealed patch fat necrosis and calcium deposits in the subcutis.