Investigation and control of outbreaks of Candida Pelliculosa catheter-related bloodstream infection in the neurosurgical intensive care unit / 中国基层医药

Objective:To investigate the causes of the outbreak of Candida Pelliculosa catheter-related bloodstream infection in the neurosurgical intensive care unit (ICU), find out the source of infection and the route of transmission, and provide evidence for the prevention and control of nosocomial infection. Methods:An epidemiological investigation and environmental hygiene monitoring were made in patients with Candida Pelliculosa catheter-related bloodstream infection who received treatment in March and April 2019 in Houma People's Hospital, China. Comprehensive measures were taken to control the outbreaks of Candida Pelliculosa catheter-related bloodstream infection. Results:There were four patients with Candida Pelliculosa catheter-related bloodstream infection in the ICU of Neurosurgery Department of Houma People's Hospital, China. Eight samples were collected from these four patients. Ten strains were isolated and identified positive for Candida Pelliculosa. Drug sensitivity test revealed identical results: the minimum inhibitory concentration (MIC) of 5-fluorocytosine, amphotericin B, fluconazole, itraconazole and voriconazole was ≤ 4 mg/L, ≤ 0.5 mg/L, < 1 mg/L, ≤ 0.12 mg/L and ≤ 0.06 mg/L, respectively. No target bacteria were detected from the environment. Candida Pelliculosa infection was not observed after taking comprehensive control measures such as strengthening hand hygiene supervision in medical staff and thorough disinfection of the environment. Conclusion:Poor hand hygiene compliance in medical staff in neurosurgical ICU and non-sufficient environmental disinfection may be the main causes for the outbreak of Candida Pelliculosa catheter-related bloodstream infection.

A Case of Candida pelliculosa Prosthetic Valve Endocarditis Treated with Anidulafungin and Valve Replacement / 감염과화학요법

Candida pelliculosa is a rare cause of human infection. In this report, we describe a case of infective endocarditis caused by C. pelliculosa in a patient with a prosthetic heart valve. A 72-year-old female presented with a complaint of blurred vision, which she had been experiencing over a period of four weeks. Transthroasic echocardiography showed vegetation on the prosthetic mitral valve. A blood culture isolate was confirmed as C. pelliculosa.

Candida en el departamento de neonatologia de la Maternidad "Concepción Palacios" enero-junio 2006 / Candida in the department of neonatalogy of the Maternity

En los últimos años la candidemia se ha incrementado en las centros hospitalarios, siendo las áreas de cuidados intensivos donde se observa con mayor frecuencia, ya que los pacientes presentan condiciones que favorecen la instauración de infecciones fúngicas. El objetivo de este estudio fue identificar y conocer la sensibilidad de las especies de Candida predominantes en el Departamento de Neonatología de la Maternidad “Concepción Palacios”. De 349 hemocultivos positivos recibidos del 01 de enero al 30 de junio del 2006; 74 (21.3%) desarrollaron Candida no albicans, con predominio de Candida pelliculosa, una levadura emergente involucrada como agente causal de fungemias, que presentó un patrón de sensibilidad variable.

In the last years the candidemia has increased in the hospital centers, being the areas of intensive care where it appears with major frequency, due to those patients present the conditions for the establishment of fungal infections. The goal of this study was to identify and to know the sensibility of Candida predominant species in the Department of Neonatology of the Maternity “Concepción Palacios”. Of 349 hemocultivos positivos received from january 01 to june 30, 2006; 74 (21.3%) desarrollaron Candida not albicans, with predominance Candida pelliculosa an emergent yeast involved as causal agent of fungemias, that there presented a pattern of changeable sensibility.