Clinical research of carboprost methylate suppository combined with romethamine in the treatment of post-partum hemorrhage in contractions fatigue / 中国基层医药

Objective To analyze the effect of carboprost methylate suppository combined with romethamine in the treatment of postpartum hemorrhage in contractions fatigue.Methods 120 cases of postpartum hemorrhage contractions fatigue were randomly divided into control group and observation group,60 cases in each group.The control group was given carboprost methylate suppository treatment,the observation group was given romethamine com-bined with carboprost methylate suppository.The 2h,12h postpartum blood loss,clinical treatment effect and adverse reaction were compared between the two groups.Results Compared with the control group,the hemostatic time of the observation group shortened,postpartum haemorrhage amount within 2h and postnatal within 12h blood loss of the observation group were reduced,the differences were statistically significant (t=4.56,5.92,6.12,all P<0.05).The total effective rate of the control group was 73.33%,which was significantly lower than 91.67% of the observation group,the difference was statistically significant (χ2 =6.12,P <0.05 ).Compared with the control group,the incidence rates of digestive tract symptoms,disposable blood pressure fluctuations,facial blushing,puerperal infection in the observation group were lower,the differences were statistically significant (χ2 =4.71,4.98,4.34,5.43,all P<0.05).Conclusion The clinical effect of carboprost methylate suppository combined with romethamine in the the treatment of contractions fatigue postpartum hemorrhage is remarkable,with less postpartum haemorrhage amount, better treatment effect,low incidence of adverse reactions and higher security.

Comparison of effects of misoprostol and carboprost methylate suppository in the painless abortion of pregnancy / 中国基层医药

Objective To compare the effects of misoprostol and carboprost methylate suppository in painless artificial abortion.Methods 164 early pregnant women who were voluntary termination of pregnancy row painless surgery and no surgery contraindications were randomly divided into the control group and the observation group,82 cases in each group.The observation group was given misoprostol 400μg in vaginal vault 1 h before surgery.Intravenous injection fentanyl 50μg,continuous intravenous injection propofol 2.0mg/kg,stopping the treatment when eyelash reflex disappeared,if necessary,additionally given propofol 0.5mg/kg.The control group was given carboprost methylate suppository(1mg) into the vaginal vault 1h before surgery,the other treatment was same as the observation group.The intraoperative BP,HR,RR,SPO2 were monitored,the cervical laxity,the total amount of propofol,operation time,recovery time,patient and surgeon satisfaction rate were recorded.Results Surgery time,recovery time,the total amount of propofol of the observation group [(3.5 ± 1.2) min,(1.9 ± 0.7) min,(105 ± 10) mg] were significantly less than the control group [(6.5 ± 1.7)min,(3.7 ± 0.6)main,(149 ± 14)mg],the relaxation of the cervix in the observation group (markedly effective in 69 cases,effective in 13 cases,ineffective in 0 case) were better than the control group (markedly effective in 52 cases,effective in 21 cases,ineffective in 9 cases).Conclusion Propofol,fentanyl compared with misoprostol combination carboprost methylate suppository had obvious cervical relaxation,significantly reducing the time dilation of the cervix,a small phenol propofol dosage,shortening the patients' recovery.time,improve the safety and satisfaction of the operation.