1.
Cancer Research and Clinic
;
(6): 353-356, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-493128
Résumé
There are approximately 85 % of malignant tumors derived from epithelial cells,and a therapeutic method of epithelial cells has become the focus of cancer treatment.Claudin-3 and Claudin-4 as important components of the tight junction structure are abundantly expressed in malignant tumors,and the clostridium perfringens enterotoxin (CPE) as Claudin-3 and Claudin-4 specific binding ligand has important significances in the treatment of tumors.However,because of the large intestinal toxicity,clinical application of CPE has been limited greatly.Carboxyl peptide fragment of CPE (C-CPE) is a specific binding domain of CPE,which has specificity without intestinal toxicity.This review will present some advances of C-CPE in cancer therapy.