Résumé
Objective@#To investigate the characteristics and prognostic factor of central nervous system (CNS) involvement in patients with hemophagocytic lymphohistiocytosis (HLH) .@*Methods@#From January 2006 to October 2015, 152 patients with HLH, 88 patients had CNS involvement, their clinical data were collected, and survival was analyzed using the Kaplan-Meier life table method, univariate and multivariate Cox regression model analyses were applied to identify the risk factors of prognosis.@*Results@#①57.9% patients complicated with neurological symptoms, cerebrospinal fluid abnormalities were observed in 37.0% patients, 57.5% patients had abnormal neuroradiology. ②36 patients survived well, 3 patients lost to follow-up, 49 dead, 1 survival patient had epilepsy. ③The 3-year overall survival rate of 88 patients was 44%. ④abnormal CSF and unreceived IT bore a significant, independent adverse prognostic value (P<0.05) .@*Conclusion@#CNS involvement in HLH has a high frequency and poor prognosis, few patients remained neurologic sequelae; abnormal CSF related to poor prognosis, positive intrathecal injections could improve the prognosis.
Résumé
Exosomes are membrane-derived vesicles of cells, and it can convey information and substances by transporting proteins, lipids and nucleic acids to target cells, thereby affecting the biological activity of target cells. Researches have shown that exosomes play important roles in neurological diseases, such as Alzheimer diseases, Parkinson diseases and prion disease, implying that the study of exosomes may have:.clinical value for treating central nervous system diseases. In this review, we summarized the generation of exosomes and the recent advances of their roles in neurological disease.