Résumé
Objective: Through searching the information of health food with the function of alleviating visual fatigue published on the Special Food Information Query Platform, and the product information data of ophthalmic proprietary Chinese medicine with health care function in the prescription database of Chinese patent medicine based on Pharmaceutical Intelligence data network, so as to provide the basis and reference for the development of the health food formulations and products with the function of relieving visual fatigue. Methods: Microsoft Excel 2016 software and Traditional Chinese Medicine Inheritance System were used to make statistics on the detected product information and analyze its formula characteristics. Results: A total of 141 kinds of health food with visual fatigue relief function were collected, of which 64 kinds (45.4%) contained traditional Chinese medicine in the formula of health food. There were six herbs of Chinese materia medica raw materials with frequency ≥ 5, which were used 145 times (72%), from high to low, Chrysanthemum morifolium, Lycium barbarum, Cassiae Semen, Mori Fructus, Rehmannia glutinosa and Poria cocos were used respectively. Three new prescriptions were obtained by unsupported entropy clustering. Non-traditional Chinese medicine raw materials are widely used in health food to alleviate visual fatigue, there were 60 products containing foreign natural plant resources and 17 products containing xanthin and vitamins. According to statistics on the products with health function in ophthalmic Chinese patent medicine, there were seven kinds of traditional Chinese medicine materials with frequency ≥ 4, which were used 32 times (29%), from high to low, they were Lycium barbarum, Cassiae Semen, Cuscuta chinensis, Rehmannia glutinosa, Chrysanthemum morifolium, Schisandra chinensis, and Plantago asiatica. A new prescription was obtained by unsupervised entropy hierarchical clustering. Conclusion: The choice of raw materials of Chinese materia medica in health food is basically consistent with traditional Chinese medicine theory in the treatment of visual fatigue principle, that is, nourishing the liver and kidney, calming liver and improving eyesight. However, they are different in the selection range of traditional Chinese medicine raw materials, the compatibility of raw materials, the types of dosage forms and so on. In addition, under the guidance of syndrome differentiation and health care theory, this paper attempts to apply the statistical method of literature data processing to screen new formulas and develop new products, which opens up new ideas and methods for the research and development of health care products of traditional Chinese medicine compound.
Résumé
Through searching the information of chemical liver injury protection function of health food on the State Food and Drug Administration website and using Microsoft Excel 2016 software and Traditional Chinese Medicine Inheritance System, to analyze formula characteristics of health food and provide the basis for the formulation of health food with auxiliary protective function in chemical liver injury and the development of the product. A total of 325 kinds of health food were collected, of which 282 (86.8%) health food formulations contained Chinese materia medica (CMM) raw materials. The number of health food with one single health care function and two healthy functions was 192 and 133, respectively. In terms of dosage forms, there were 156 capsules, which account for about half of the total. Moreover, there were 21 kinds of CMM raw materials with more than 18 of the use frequency (f) and accumulated 768 times (73%). Nine new prescriptions were obtained by unsupervised entropy hierarchical clustering. The CMM is widely used in the health food which has the auxiliary protective function in the chemical liver injury. The choice of dosage forms is based on convenience of taking and carrying. Five commonly used functional ingredients are total flavonoids, crude polysaccharides, puerarin, total saponins, and taurine. The choice of CMM is basically consistent of the principle of traditional Chinese medicine treatment of chemical liver disease which are detoxification, strengthening the body resistance, promoting blood circulation, clearing away heat, dehumidification and so on. The most commonly used drugs are anti-alcoholismic drugs, tonic medicine, blood-activating and stasis-resolving drugs, heat-clearing drugs, and damp-draining diuretic. Nine new prescriptions found by software must be further evaluated in combination with the theory and practice of Chinese medicine and comprehensive analysis.