The relationship between female anti-sperm immune infertility and chronic inflammation in female reproductive tract / 中国生化药物杂志

Objective To investigate relationship between anti-sperm immune infertility and chronic inflammation in female reproductive tract.Methods80 patients of anti-sperm immunity infertility were selected, and randomly divided into the study group and the control group.The study group was treated with dexamethasone+Vitamin E+Vitamin C+roxithromycin, the control group was treated with dexamethasone+vitamin E+vitamin C, After a course of treatment, serum IL-6, TNF-α and the AsAb in serum and cervix change was detected before and after treatment.ResultsThe clinical efficacy of study group was significantly better than the control group, with statistical significance (P<0.05).the AsAb in serum and cervix in the study group was significantly lower than the control group, with a statistically significant difference (P<0.05).serum IL-6, TNF-α in the study group was significantly lower than the control group, with significant difference (P<0.05).ConclusionThe female anti-sperm immune infertility and the chronic inflammation in female reproductive tract are relational, The female anti-sperm immune infertility combined with antibiotic has a significant effect.

Research on the relationship between chronic inflammation in female reproductive tract and anti-sperm immunity / 中国免疫学杂志

Objective:To study the immunological responds to sperm antigens in the condition of chronic inflammation in female reproductive tract. The results would be useful for preventing antisperm immunity infertility.Methods:①Patients: 50 women in chronic cervicities and/or chronic pelvic peritonitis were observed, and 10 healthy women for normal control. ②The patients and the control group were tested serum ASAb, pathogens culture in cervical mucus, subsequent lymphocyte (including CD3, CD4,CD8 and CD4/CD8),and IL 2 level in the cervical mucus.Results:①The serum ASAb level in the patients was higher than the control group (P