Circulating cell-free nucleic acids in cancer liquid biopsy and its clinical application / 肿瘤

As the development of current advanced biotechnologies, the detection of circulating cell-free nucleic acid (cfNA) as a noninvasive liquid biopsy biomarker has emerged recently. Compared with the traditional tissue biopsy for pathological diagnostics, cfNA as a noninvasive liquid biopsy biomarker has shown many advantages, such as overcoming the heterogenicity of cancer cells and noninvasive sampling procedure. Recently, the detection of cfNA has emerged as a promising noninvasive biomarker in cancer diagnosis, prognosis prediction, and treatment response evaluation. This review article is to summarize the application of cfNA, including circulating cell-free DNA (cfDNA) and circulating cell-free RNA (cfRNA) in cancer liquid biopsy field.