Résumé
Background: Neonatal sepsis refers to generalized bacterial blood stream infection in first 28 days of life documented by positive blood cultures. It is one of leading causes of neonatal mortality. Objectives was to study clinicobacteriological, antibiotic sensitivity patterns and mortality of neonatal sepsis.Methods: This prospective study was conducted in the Department of Pediatrics of Government Medical College Srinagar in collaboration with Department of Microbiology of same medical college after ethical clearance from ethical committee of Government Medical College Srinagar. One hundred (100) neonates out of 731 neonates admitted between octomber2007 and September 2008 with signs and symptoms of neonatal sepsis were included in our study by random sampling method. After history, examination and laboratory investigation blood culture results were analyzed by standard statistical methods.Results: The blood culture was positive in 40% of neonates. Fifty one (51) neonates were males while as 49 were females. Sixty three (63) neonates had late onset of sepsis while as 37 had early onset sepsis. The positive' blood culture was more common in males, late onset sepsis, babies born in rural areas, home born, vaginal births, preterm and other' low birth weight neonates .The gram negative isolates were most common followed by positive ones .The best sensitivity of gram negative isolates was to ciprofloxacin followed by amikacin and cephalosporins while as gram positive isolates were sensitive to imipenum followed by vancomycin. Pseudomonas was most responsive to pipercillin +tazobactum combination. The neonatal mortality was 35% being higher in early onset sepsis and low birth weights.Conclusions: This study depicts a high rate of neonatal sepsis, mainly caused by gram negative organisms followed by gram positive organisms with rising drug resistance that could bear far reaching implications to the times to come, mandating the implementation of sepsis preventive measures and administration of specific antibiotics.
Résumé
Background:Lower Respiratory Tract Infection(LRTI) is one of the commonest health problem which is not a single disease but a group of specific infections with varying etiology and symptomatology. This study was undertaken to determine bacterial etiology of LRTI and associated risk factors 250 samples from patients with suspected LRTI were collected Methodology:and processed by standard microbiological procedure. Risk factors relating to LRTI were also further evaluated from clinical history of the patient. Total 100 isolates were recovered where Klebsiella pneumoniae(57%) was predominant followed by Pseudomonas Results:aeruginosa(19%), Acinetobacter spp.,(9%), Citrobacter freundii(7%), Staphylococcus aureus(3%), and Streptococcus pneumoniae(2%). Multiple co-morbidities are more associated with LRTI than single risk factor like Diabetes mellitus, Smoking, Alcohol, Hypertension and COPD. Knowledge of bacterial agents causing LRTI and prevalent risk factors in our geographical area is to be required for better Conclusion:treatment and prevention of the disease