Résumé
Sodium sulfate·sodium bicarbonate bathing is known to exert stimulatory effect upon an increase in cutaneous circulation after bathing due to its skin-coating and vasodilating action. In the study, authors investigate the change in cutaneous blood flow after artificial sodium sulfate·sodium bicarbonate bathing in the healthy man, and clarify its antihypertensive effect upon diurnal variations in blood pressure in patients with essential hypertension.<br>The results obtained are as follows.<br>1) Changes in cutaneous blood flow after bathing were studied in five healthy volunteers. Sodium sulfate·sodium bicarbonate bathing (40°C, 10 min) resulted in a significant increase in cutaneous blood flow 30 min after the beginning of bathing, comparing with plain water bathing. Thermographic study on body surface revealed the findings corresponding to the change in cutaneous blood flow.<br>2) Diurnal changes in blood pressure after bathing were studied in ten patients with essential hypertension, who had been treated with hypotensive drugs. No significant difference of hyperbaric indici in systolic, diastolic and mean blood pressure (MBP) was observed between sodium sulfate and plain water as a whole. However, six cases out of ten showed the significant decrease in MBP after sodim sulfate·sodium bicarbonate bathing, comparing with the plain water bathing.<br>From these findings it is expected that artificial sodium sulfate·sodium bicarbonate bathing is available as a supportive therapy for refractory hypertension to medicaments.
Résumé
Effect of carbon dioxide bath on cardiovascular functions and peripheral circulation were studied using a new system of carbon dioxide bath. The subjects consisted of 13 males and 17 females, ranging from 50 to 84 years old, 67.4±8.3 in average, having the complaints resulting mainly from arteriosclerosis such as coldness on extremities or exertional pains of lower extremities. Each subject took a bath in plain water (PW) on the first experimental day and then a bath in carbon dioxide (CO<sub>2</sub>) at the same time on the second experimental day. Both baths were done for 10min. at 39°C of water temperature. The results obtained were as follows.<br>1) Mean blood pressure (MBP) was elevating during bath and lowered below prebath level immediately after bath in both PW and CO<sub>2</sub> groups. However, MBP in CO<sub>2</sub> group was lower significantly (p<0.05) than in PW group 20 and 30min after bath.<br>2) Both body and skin temperatures were similarly elevated at all points to be measured directly after bath, and then lowerd gradually thereafter. There was no significance in changes between both groups.<br>4) An increase in cutaneous blood flow was observed at the same grade in both groups during and after bath, though no showing significant difference between both groups.<br>5) PO<sub>2</sub> in venous blood increased after bath, while PCO<sub>2</sub> decreased. However, no significant difference in these changes was observed between both groups.<br>6) Tendency to increase in CV R-R was observed during and after bath, though no significant difference was showed between both groups.<br>7) Relating to the feeling to bath, all subjects had the feeling of “warmness” at the beginning of bath and also of comfortableness during and after bath in both PW and CO<sub>2</sub> groups. However, there was no difference in the intensity of these feelings between both groups.<br>8) No side reaction due to an inhalation of carbon dioxide during bath was observed in all subjects.<br>From these results, it is expected that a new carbon dioxide bath results in benefit for patients with disturbance of peripheral circulation.
Résumé
The ability of nicotinic acid and its substitutes to increase cutaneous blood flow has been measured by laser Doppler flowmeter in 30 healthy human volunteers. We applied nicotinarnide, nicotinic acid ethyl ester, nicotinic acid methyl ester, hexyl nicozinate each in an acqeous solution at a concentration of 10 mM/liter for 10 minutes occlusion on the forearm. The change of blood flow was serially checked at 5 to 10 minutes intervals for one hour. The study results were as follows : l. The relative maximum cutaneous blood flow response was in following order nicotinic acid methyl ester(100%), nicotinic acid ethyl ester(98%), hexyl nicotinate (84%) and nicotinic acid(63%). However, there was no statistically significant difference(p>0.05) between each drug. There was statististically significant difference between nicotinamide and all other nicotinic acid substitutes(p<0.05). 2. The time required to reach maximum blood flow response was 6.7 minutes for hexyl nicotinste, 10 minutes for nicotinic acid ethyl ester, 12.5 minutes for nicotinic acid methyl ester and 20 minutes for nicotinic acid. However, there was statistically significant difference between hexyl nicotinate and nicotinic acid only(p<0.05). 3. Significant decrease of cutaneous blood flow was observed one hour after the removal of the patches in all drugs.