Low deceleration capacity is associated with higher stroke risk in patients with paroxysmal atrial fibrillation / 中华医学杂志(英文版)

Background@#Deceleration capacity (DC) is a non-invasive marker for cardiac autonomic dysfunction; however, few studies have shown that the influence factors of cardiac autonomic dysfunction and the correlations between DC and stroke risk in paroxysmal atrial fibrillation (AF). We aimed to explore the influencing factors of abnormal DC and the relationships between DC and stroke risk in patients with paroxysmal AF.@*Methods@#The study included hospitalized paroxysmal AF patients with DC measurements derived from 24-h Holter electrocardiography recordings taken between August 2015 and June 2016. Multivariable regression analysis was performed to evaluate the associations between correlated variables and abnormal DC values. The relationship between DC and ischemic stroke risk scores in patients with paroxysmal AF was analyzed.@*Results@#We studied 259 hospitalized patients with paroxysmal AF (143 [55.2%] male, mean age 66.4 ± 12.0 years); 38 patients of them showed abnormal DC values. In the univariate analysis, age, hypertension, heart failure, and previous stroke/transient ischemic attack (TIA) were significantly associated with abnormal DC values. Among these factors, a history of previous stroke/TIA (odds ratio = 2.861, 95% confidence interval: 1.356–6.039) were independently associated with abnormal DC values in patients with paroxysmal AF. The abnormal DC group showed a higher stroke risk with the score of congestive heart failure, hypertension, age >75 years, diabetes mellitus, previous stroke and TIA (CHADS2) (2.25 ± 1.48 vs. 1.40 ± 1.34, t = -4.907, P = 0.001) and CHA2DS2-vascular disease, age 65–74 years and female category (VASc) (3.76 ± 1.95 vs. 2.71 ± 1.87, t = -4.847, P = 0.001) scores. Correlation analysis showed that DC was negatively correlated with CHADS2 scores (r = -0.290, P < 0.001) and CHA2DS2-VASc scores (r = -0.263, P > 0.001).@*Conclusions@#Lower DC is closely associated with previous stroke/TIA, and is also correlated negatively with higher stroke risk scores in patients with paroxysmal AF. It could be a potential indicator of stroke risk in paroxysmal AF patients.

Changes in heart rate deceleration capacity and variability in resting children with vasovagal syncope / 中华实用儿科临床杂志

Objective@#To investigate the changes in heart rate deceleration capacity(DC) and heart rate va-riability(HRV) parameters in children with vasovagal syncope(VVS), to assess the basic autonomic function of children with VVS, and to explore the reference value of DC for the diagnosis of VVS in children.@*Methods@#VVS group included 62 patients diagnosed with VVS in the Cardiovascular Department of Children′s Hospital Affiliated to Capital Institute of Pediatrics from June 2015 to December 2017, 56 outpatients undergoing physical examination were selected as the healthy control group, and the changes in DC and HRV matched to age and gender were analyzed respectively.Indexes of DC and HRV of both groups of children in health control group and children with VVS were compared among different age groups or different genders.@*Results@#(1)Analysis of DC and HRV based on age or gender: whether in healthy children or in children with VVS, DC and HRV parameters varied significantly in the range of different ages, while they were the same in children with different genders.(2)Comparison of DC and HRV in school-age and puberty children between VVS group and healthy control group: in school-aged children, DC of VVS group was significantly higher than that of healthy control group [(6.8±1.0) ms vs.(6.0±0.7) ms, t=-2.412, P<0.01]. Mean square root rates of succe-ssive normal sinus RR interval differences(rMSSD) increased, and the difference was significant (P<0.05). In children at puberty, DC in children of VVS group was significantly higher than that in the healthy control group [(7.4±1.2) ms vs.(6.6±1.1) ms, t=-2.742, P<0.01], rMSSD, LF and HF value were significantly higher compared with those of the healthy control group (all P<0.05). (3)Predictive value of DC on VVS: the binary Logistic regression analysis found that only DC was associated with VVS in different age groups.By using receiver operating characteristic curve to analyze the predictive value of DC on VVS, it was found that when making DC 6.5 ms for school age and 7.0 ms at puberty as the threshold, a better prediction of VVS could be achieved with good sensitivity and specificity.@*Conclusions@#Children′s autonomic nervous function changes with age, and DC and HRV parameters change significantly during adolescence and at school age.Children with VVS may have abnormally increased vagal tone.When DC ≥6.5 ms at school age or DC≥7.0 ms at puberty, it may have a reference value for the diagnosis of VVS.

Changes in heart rate deceleration capacity and variability in resting children with vasovagal syncope / 中华实用儿科临床杂志

Objective To investigate the changes in heart rate deceleration capacity( DC)and heart rate va-riability(HRV)parameters in children with vasovagal syncope(VVS),to assess the basic autonomic function of children with VVS,and to explore the reference value of DC for the diagnosis of VVS in children. Methods VVS group included 62 patients diagnosed with VVS in the Cardiovascular Department of Children＇s Hospital Affiliated to Capital Institute of Pediatrics from June 2015 to December 2017,56 outpatients undergoing physical examination were selected as the healthy control group,and the changes in DC and HRV matched to age and gender were analyzed respectively. Indexes of DC and HRV of both groups of children in health control group and children with VVS were compared among different age groups or different genders. Results (1)Analysis of DC and HRV based on age or gender:whether in healthy children or in children with VVS,DC and HRV parameters varied significantly in the range of different ages,while they were the same in children with different genders.(2)Comparison of DC and HRV in school-age and puberty children between VVS group and healthy control group:in school-aged children,DC of VVS group was significantly higher than that of healthy control group[(6. 8 ± 1. 0)ms υs.(6. 0 ± 0. 7)ms,t= -2. 412,P<0. 01]. Mean square root rates of succe-ssive normal sinus RR interval differences(rMSSD)increased,and the difference was significant( P<0. 05). In chil-dren at puberty,DC in children of VVS group was significantly higher than that in the healthy control group[(7. 4 ± 1. 2)ms υs.(6. 6 ± 1. 1)ms,t= -2. 742,P<0. 01],rMSSD,LF and HF value were significantly higher compared with those of the healthy control group(all P<0. 05).(3)Predictive value of DC on VVS:the binary Logistic regression analysis found that only DC was associated with VVS in different age groups. By using receiver operating characteristic curve to analyze the predictive value of DC on VVS,it was found that when making DC 6. 5 ms for school age and 7. 0 ms at puberty as the threshold,a better prediction of VVS could be achieved with good sensitivity and specificity. Conclusions Children＇s autonomic nervous function changes with age,and DC and HRV parameters change signifi-cantly during adolescence and at school age. Children with VVS may have abnormally increased vagal tone. When DC≥6. 5 ms at school age or DC≥7. 0 ms at puberty,it may have a reference value for the diagnosis of VVS.

Clinical research status of deceleration capacity / 国际儿科学杂志

Deceleration capacity (DC) is a noninvasive measurement of autonomic nervous function.It is a quantitative assessment of vagal tone.Compared with the conventional measurements of heart rate variability (HRV),deceleration capacity has higher accuracy and stability.It is widely used in cardiology,endocrinology,obstetrics and gynecology,pediatrics and other fields.Deceleration capacity can be used to assess the risk of sudden death in patients with coronary heart disease and myocardial infarction,to evaluate the prognosis and risk of death in patients with chronic heart failure,to explore the pathogenesis of vasovagal syncope,to assess the autonomic nervous function in patients with type 2 diabetes mellitus,to predict the occurrence of cardiovascular events,and to detect the physiological condition of pregnancies complicated by hypertensive disorders and immature fetuses.The value of heart rate deceleration capacity in clinical application has been widely recognized.This paper aims to summarize the significance,value and research status of deceleration capacity in the diagnosis and prognosis of various diseases.

Correlation between the heart rate deceleration capacity and the scope of coronary artery lesions in patients with unstable angina pectoris / 中国综合临床

Objective To investigate the changes of heart rate deceleration capacity(DC)in patients with unstable angina pectoris(UAP)and its correlation with the scope and severity of coronary artery disease. Methods From September 2016 to January 2017,one hundred and nine patients with UAP and 52 with non-coronary artery disease were diagnosed in the department of cardiology in the Third Affiliated Hospital of Anhui Medical University. They were all measured with 24h dynamic electrocardiogram and the corresponding analysis software was used to analyze the results,and the difference in deceleration capacity between the two groups was compared. The severity and the number of coronary artery lesions were compared with different deceleration capacity in UAP patients. The relationship between deceleration capacity and the number of coronary artery stenosis, the scope and severity of coronary artery lesions were then analyzed. Results The deceleration capacity value of UAP group was significantly lower than that of the control group((5.10 ± 1.34)vs.(6.03 ±1.40),t=-3.775,P<0.01). The number of coronary artery lesions and Gensini score in group deceleration capacity>4.5 ms were smaller than those in group deceleration capacity ≤4.5 ms((1.67± 0.77)branches vs. (26.76±25.31)branches;(21.27±5.541)points vs.(42.69±8.61)points)(t= -3.910,-2.277,P<0.05). The deceleration capacity value was negatively correlated with the number of coronary artery stenosis(r=-0.206,P<0.01)and the Gensini score(r=-0.358, P<0.01)in patients with UAP. Conclusion Deceleration capacity decreased in patients with UAP and it was closely associated with the severity and the scope of coronary artery lesions.

Phase-rectified signal averaging for the assessment of automatic nervous system activity in surgery during general anesthesia / 临床麻醉学杂志

Objective To observe the feasibility of phase-rectified signal averaging applied for the evaluation of automatic nervous system activity in general anesthesia.Methods Forty-seven fe-males and 63 males aged 18-65 years,ASA falling into category Ⅰ or Ⅱ,scheduled for oral maxillo-facial surgery under general anesthesia were selected.The heart rate variability(HRV)signal was re-corded by Powerlab throughout the operation,and then it was sectioned into three segments with 5 minutes:pre-anesthesia(T0 ),means the waking state before the operation;intra-anesthesia(T1 ),the period of operation in 25-30 min;post-anesthesia(T2 ),the consciousness recovery state in the end of the operation.All indicators of HRV analysis was calculated in the time domain.SpO 2 ,MAP and BIS were recorded synchronously in the three periods.Results Compared with T0 ,DC, RMSSD, SDNN,SD1,SD2,logTP,logLF,logHF were significantly lower at T1 and T2 (P <0.05).In con-trast to T1 ,HR,MAP and BIS were significantly higher at T2 (P <0.05 ),DC,RMSSD,SDNN, SD1,SD2,logTP,logLF,logHF were significantly increased at T2 (P <0.05 ).There was positive relation between DC and RMSSD,SD1,logHF (r =0.905,0.909,0.932,respectively,P <0.01). Conclusion As 5 min-DC could indicate the character of PRSA,especially its specificity in showing vagus nerves activities,it is feasible that DC is used to observe the autonomic nerve activity intra op-eration.

Analysis of influencing factors of heart rate deceleration capacity in patients with dilated cardiomyopathy / 中华心血管病杂志

Objective@#To investigate the determinants affecting the heart rate deceleration capacity (DC) in patients with dilated cardiomyopathy (DCM).@*Methods@#One hundred patients with DCM (DCM group) and 202 healthy subjects (control group) were respectively enrolled. Echocardiography and 24 hours electrocardiogram were performed in all subjects. DC value was compared between the two groups. Multiple regression analysis was made to evaluate the related determinants of DC ((age, sex, echocardiographic parameters including the left atrial diameter (LAD) and left ventricular ejection fraction (LVEF)).@*Results@#(1) DC value was significantly lower in DCM group than in control group( (4.40±2.03) ms vs. (7.30±1.81) ms, P<0.01), prevalence of DC value≤4.5 ms was significantly higher in DCM group than in control group (62% vs. 6%, P<0.01). (2) DC value in the DCM group decreased in proportion to increasing LAD dimension, DC value was (5.60±2.04) ms, (4.50±2.07) ms and (3.60±1.62) ms (P<0.05) in DCM patients with LAD≤40 mm, 40 mm<LAD≤50 mm and LAD>50 mm, respectively. (3) DC value in the DCM group was negatively related to the LAD (r=-0.366, P<0.01), positively related to the LVEF (r= 0.241, P<0.01), but not related with age and sex. Multiple factors regression analysis showed that increased LAD was related to the reduced DC values independtly.@*Conclusion@#DC value of the patients in the DCM group is decreased, which indicate the decrease of the vagus nerve tension, and increased LAD is related to the reduced DC value independtly in DCM patients.

Deceleration Capacity—A Novel Measure for Autonomic Nervous System in Patients with Vasovagal Syncope on Tilt-table Testing / 华中科技大学学报（医学）（英德文版）

This study was to investigate the changes of autonomic nerve function and hemodynamics in patients with vasovagal syncope (VVS) during head-up tilt-table testing (HUT).HUT was performed in 68 patients with unexplained syncope and 18 healthy subjects served as control group.According to whether bradycardia,hypotension or both took place during the onset of syncope,the patients were divided during the test into three subgroups:vasodepressor syncope (VD),cardioinhibitory syncope (CI) and mixed syncope (MX) subgroups.Heart rate,blood pressure,heart rate variability (HRV),and deceleration capacity (DC) were continuously analyzed during HUT.For all the subjects with positive responses,the normalized low frequency (LFn) and the LF/HF ratio markedly decreased whereas normalized high frequency (HFn) increased when syncope occurred.Syncopal period also caused more significant increase in the power of the DC in positive groups.These changes were more exaggerated compared to controls.All the patients were indicative of a sympathetic surge in the presence of withdrawal vagal activity before syncope and a sympathetic inhibition with a vagal predominance at the syncopal stage by the frequency-domain analysis of HRV.With the measurements ofDC,a decreased vagal tone before syncope stage and a vagal activation at the syncopal stage were observed.The vagal tone was higher in subjects showing cardioinhibitory responses at the syncopal stage.DC may provide an alternative method to understand the autonomic profile of VVS patients.

Characteristics of deceleration capacity and Tp-e/QT value in different age groups of patients with diabetic autonomic neuropathy / 中国糖尿病杂志

Objective To investigate characteristics of deceleration capacity (DC) and Tp-e/QT value in different age groups of patients with diabetic autonomic neuropathy, and to analyze their influencing factors. Methods A total of 487 subjects were enrolled in this study, and divided into three groups:patients with diabetic autonomic neuropathy (DM+CAN group,n=287), normal glucose tolerance patients with diabetic autonomic neuropathy (CAN group,n=130) and healthy controls (NC group,n=150).Then the DM+CAN group were further divided into three subgroups according to age tertiles:the lowest tertile group (35.0~47.2 years old,n=91),the middle tertile group (47.3~59.6 years old,n=116)and the highest tertile group (59.7~72.0 years old,n=80).All subjects were underwent 24-hour dynamic electrocardiogram recordings.DC and Tp-e/QT values were calculated,and then the correlation between DC and Tp-e/QT with other indicators was analyzed. Results The levels of WC,SBP,BMI,FPG,HbA1c,FIns and HOMA-IR were higher in DM+CAN group than in CAN group and in NC group (P0.05).DC increased [(2.90±0.47) vs (4.22±0.41) vs (4.97±0.35) ms],and the Tp-e/QT decreased [(0.23±0.05) vs (0.18±0.03) vs (0.12±0.02)] from the highest tertile group to the lowest tertile group,(P<0.05 or P<0.01),and the pairwise comparisons were statistically significant (P<0.05 or P<0.01).Multiple stepwise regression analysis showed that age,DM duration,WC,FPG,HbA1c,complicated with hypertension and coronary heart disease (CHD) were risk factors for DC and Tp-e/QT values (P<0.05). Conclusion Together with the increased age,DC level is reduced and Tp-e/QT value increased in patients with diabetic autonomic neuropathy.Dynamic electrocardiogram should be considered in patients with advanced age,long DM duration,high level of WC,FPG,HbA1c,and complicated with hypertension and CHD,in order to prevent the occurrence of cardiovascular events effectively.

Clinical research of heart rate variability and deceleration capacity in children with idiopathic ventricular premature ;contraction / 临床儿科杂志

Objective To explore the relationship between heart rate variability (HRV) and deceleration capacity (DC) in children with idiopathic ventricular premature contraction of different origins. Methods The clinical data from 155 children with idiopathic ventricular premature contraction were retrospectively analyzed. According to the age, the children were divided into young children group (

Analysis of changes and correlation with deceleration capacity of rate in the patients with coronary heart disease / 中国医师进修杂志

Objective To explore the changes of deceleration capacity of rate (DC) and analyze its correlation with heart rate variability (HRV) and other factors in patients with coronary heart disease. Methods One hundred and twenty-nine patients with coronary heart disease (coronary heart disease group) and 109 healthy people (control group) were enrolled in this study. DC and HRV parameters were measured by using digitized 24 h Holter. The correlation between DC and HRV parameters, other factors were analyzed. Results The levels of DC, SDNN, SDANN, SDNNi, PNN50, TP, LF, HF, AC in coronary heart disease group were significantly lower than those in control group:(5.64±1.67) ms vs. (6.71±1.47) ms, (106.60±20.53) ms vs. (138.82±31.22) ms, (96.94±20.06) ms vs. (127.47±31.87) ms,(28.53±14.75) ms vs. (52.24±14.65) ms, 87.72%vs. 103.86%,(1 967.10±966.16) ms2/Hz vs. (2 846.70±1 443.41) ms2/Hz,(326.43±195.35) ms2/Hz vs.(457.64±254.30) ms2/Hz, 85.88 vs. 106.39, (-6.18±2.15) ms vs. (-7.00±2.51) ms, P<0.05 or<0.01. DC was correlated with SDNNi, PNN50,TP,LF, HF, AC both in total population or in coronary heart disease group and control group by using multiple linear correlation analysis ( r=0.586, 0.356, 0.531, 0.563, 0.435,-0.433, P<0.01). After removing confounders, DC was correlated with age, SDNNi, rMSSD, PNN50 and AC (P<0.01). Conclusions DC decreases in patients with coronary heart disease and is strong correlativity with HRV parameters. DC could be used for quantitative detection of autonomic nervous function.

Characteristics of Deceleration Capacity and Heart Rate Variability in Patients With Vasovagal Syncope / 中国循环杂志

Objective: To quantitatively evaluate the abnormal tense of parasympathetic nerve via measuring the heart rate deceleration capacity (DC) and heart rate variability (HRV) in patients with vasovagal syncope (VVS). Methods: Our research included 2 groups: VVS group,n=28 patients with positive head-up tilt test treated in our hospital from 2013-06 to 2014-08 and Control group,n=30 patients without cardiovascular disorders. The DC and HRV were examined and compared between 2 groups. Results:① The overall deceleration capacity (ODC) (9.4 ± 2.9) ms and daytime deceleration capacity (DDC) (8.9 ± 2.9) ms in VVS group were higher than those in Control group (7.5 ± 2.5) ms and (7.5 ± 2.5) ms respectively,P1 than those in Control group (9/28, 32.1% vs 2/30, 6.7%),P=0.019.③ The SDNN (139.8 ± 34.0) ms, SDSD (29.9 ± 15.7) ms and rMSSD (40.9 ± 18.8) ms in VVS group were higher than those in Control group, (115.5 ± 29.4) ms, (21.8 ± 6.6) ms and (28.9 ± 8.4) ms respectively,P Conclusion: VVS patients have abnormally increased indexes of DC and HRV, HDC is the predictor for vasovagal syncope occurrence.

Clinical value of heart rate deceleration capacity test in predicting epirubicin-induced cardiotoxicity / 中国肿瘤临床

Objective:To investigate the effectiveness of heart rate deceleration capacity (DC) measurement in predicting the car-diotoxicity of malignant tumor patients treated with epirubicin-based chemotherapy. Methods:The clinical medical records, including CK-MB and cTnI levels and dynamic electrocardiogram (ECG) parameters before and after each chemotherapy cycle, of 140 patients treated with epirubicin-based chemotherapy were analyzed. Patients were divided into the DC>4.5 ms group and the DC≤4.5 ms group based on the calculated DC values. The CK-MB and cTnI levels and the dynamic ECG parameters of the two groups were compared af-ter two and four cycles of chemotherapy. Results:Patients in the two groups exhibited no statistically significant difference in their rele-vant clinical and pathological data before receiving chemotherapy (P>0.05). However, after four cycles of chemotherapy, the DC≤4.5 ms group showed a significantly greater increase in serum CK-MB and cTnI concentrations over the pre-chemotherapy levels compared with the DC>4.5 ms group. After two and four cycles of chemotherapy, the DC≤4.5 ms group also exhibited a significantly greater in-crease in mean heart rate (beats/min) and supraventricular and ventricular arrhythmia counts (times/24 h) over the pre-chemotherapy values compared with the DC>4.5 ms group (P0.05). However, the DC values of patients with elevated cTnI were significantly lower than those with normal cTnI level (P<0.05). Conclusion:The risk of epirubicin-induced cardiotoxicity increased with decrease in DC value. The DC test was shown to be an effective predictor of the risk of epirubicin-induced cardiotoxicity.

The predictive value of deceleration capacity of heart rate for sudden cardiac death after acute myocardial infarction / 天津医药

Objective To investigate the predictive value of the non-invasive indicator deceleration capacity of heart rate (DC) in the sudden cardiac death (SCD) after acute myocardial infarction. Methods A total of 417 myocardial infarc?tion patients with ST-segment elevation in sinus rhythm were enrolled in this study. DC was assessed from data of 24-hour ECG Holter. Regular follow-ups were carried out within 12 months. The SCD events were recorded and compared with pa?tients without SCD. Results During 12 months of follow-up, 20 patients were died due to SCD (4.8%). Compared with sur?vival group, patients showed significantly lower left ventricular ejection fraction (LVEF, 0.393 ± 0.065 vs 0.528 ± 0.042, P<0.05) and DC [(2.85±1.66) ms vs (5.49±1.71) ms,P<0.05]in SCD group. Multivariate Cox proportional hazard regression analysis showed that lower LVEF(<0.35)[RR: 2.167(1.384-4.661), P=0.013]and DC (DC<4.5 ms)[RR: 3.706(2.709-5.374),P=0.020]were risk factors for the occurrence of SCD. The prediction sensitivity by the decreased LVEF and DC was 52.1%and 76.4%respectively, and the specificity was 84.5%and 86.1%respectively. Conclusion The decreased value of DC after acute myocardial infarction can predict the SCD events.

Effect of six-minute walking training on autonomic nerve function in patients having chronic heart failure / 中国医师进修杂志

Objective To investigate the influence of six-minute walking training on autonomic nerve function in patients having chronic heart failure.Methods Eighty chronic heart failure patients with heart function Ⅱ-Ⅲ grade were divided into training group (40 cases) and control group (40 cases) by random digits table method.Patients in two groups were treated with conventional anti heart failure drug.Patients in training group insisted six-minute walking training twice a day on the basis of the conventional treatment.Changes of the index of heart function,heart rate variability (HRV) and heart rate deceleration force (DC) before and after treatment were tested in two groups.Results After treatment,the cardiac function in training group and control group was significantly improved (P ＜ 0.05).The indexes of HRV and DC in two groups were significantly higher than those before treatment (P ＜ 0.05).After treatment,the indexes of HRV and DC in training group were significantly higher than those in control group (P ＜ 0.05).Conclusion Six-minute walking training in patients having chronic heart failure can significantly improve the autonomic nerve function,which is an effective and safe rehabilitation exercise for patients having chronic heart failure.

The influence of deceleration capacity of heart rate and heart rate deceleration runs on evaluating short-term prognosis of 115 patients with acute myocardial infarction / 重庆医学

Objective To investigate the effects of altered deceleration capacity of heart rate (DC) and heart rate deceleration runs(DRs) on the short-term prognosis of patients with acute myocardial infarction (AMI) .Methods 115 patients confirmed with AMI within 7 days as AMI group ,50 persons without MI were selected as control group .The deceleration capacity of heart rate and heart rate deceleration runs were detected by the 24 hours Holter within 7 to 14 after onset of AMI ,all the patients were divided in-to high risk group ,medium risk group and low risk group through the Holter results .Left ventricular ejection fraction (LVEF) was evaluated by echocardiography .Compare the risk of the AMI group with the control group .Meanwhile the AMI patients were fol-lowed up for mean(9 .2 ± 1 .7)months .Observe the presence of major adverse cardiovascular events (MACE) .All AMI patients were classified into MACE and non-MACE groups according to the presence of MACE .Analysis the risk factors of MACE .Results AMI group had a significant increase risk but decrease in deceleration capacity of heart rate (P<0 .05) as compared with the control group .In MACE group ,the rate of high risk was significant increasing(P=0 .005) ,but the rate of low risk was significant decrea-sing(P=0 .039) .The Logistic regression analysis showed that LVEF ,high risk group ,age and percutaneous transluminal coronary intervention(PCI) were independent risk factors on presence of MACE .Correlation r was 0 .33 ,0 .30 ,0 .23 ,0 .18 respectively ,and odds ratio was 4 .83 ,4 .28 ,2 .22 ,1 .58 respectively ,the correlation with deceleration capacity of heart rate was a little weaker than LVEF .The coefficient of determination r2 was 0 .528 when the LVEF and ages went into regression ,whereas that was 0 .635 when the LVEF ,high risk group and age went into regression together .Conclusion Capacity of heart rate decelerate was significantly weakened in AMI patients .LVEF ,the significantly decreased deceleration capacity of heart rate ,age and PCI were independent risk factors on presence of short-term MACE in AMI patients .The prognostic value of the DC and DRs was a little weaker than the LVEF .The better predictive value was obtained if the LVEF ,the significantly decreased deceleration capacity of heart rate ,age were combined .