RÉSUMÉ
Objective To investigated the effect of TangNaiKang (TNK) on VEGF protein expression of GK rats Thoracic aorta. Methods 51 male GK rats were divided into five groups randomly: model group, pioglitazone group, and TNK treatment group (low, immediate and high dose). Another 10 male Wistar rats were served as normal control group. GK rats were fed with high-grease forage, while normal control group was fed with a standard diet. Fasting blood glucose, general HE staining and VEGF protein expression were detected by immunohistochemistry. Results The fasting glucose had a significant decline in TNK treatment groups. HE staining showing TNK can ameliorate intima thickness, reduce hyperplasia of shallow vascular smooth muscle cell, and improve wavy and plexiform arrangement of elastic lamina. Immunohistochemistry also showed that TNK decreased VEGF protein expression of great vessels. Conclusion TangNaiKang can prevent and cure diabetic vascular complication of GK rats.
RÉSUMÉ
CONTEXTO: Não há estatísticas precisas sobre o número de amputações realizadas anualmente, mas é conhecido o comprometimento da qualidade de vida desses indivíduos e a necessidade de uma equipe multiprofissional para sua reabilitação. OBJETIVO: Analisar todas as amputações de membros inferiores realizadas pelo Serviço de Angiologia e Cirurgia Vascular do Hospital Universitário Regional de Maringá entre 2000 e 2006. MÉTODOS: Estudo descritivo e retrospectivo a partir dos prontuários de pacientes submetidos a amputação ou desbridamento cirúrgico de membros inferiores por trauma ou doença vascular. RESULTADOS: Ocorreram 116 procedimentos, sendo 84,5 por cento amputações e 15 por cento desbridamentos cirúrgicos, em 111 pacientes, sendo 78 homens e 33 mulheres, cuja média das idades foi de 63,4 anos (4 a 100 anos), sendo os principais fatores etiológicos: doenças vasculares (92,8 por cento) e trauma (7,2 por cento). As comorbidades e fatores de risco mais prevalentes foram: hipertensão arterial sistêmica (66 por cento), diabetes melito (60 por cento), tabaco (28 por cento) e arritmia cardíaca (0,9 por cento). Quanto à escolaridade, se observou que 52,2 por cento dos pacientes cursaram apenas o ensino fundamental, 6,5 por cento fizeram o ensino médio, completo ou incompleto, e 41,3 por cento eram analfabetos. A percentagem de pacientes submetidos à amputação primária foi de 94,9 por cento, e secundárias, 5,1 por cento. No entanto, houve diminuição progressiva do coeficiente desses procedimentos a cada ano. CONCLUSÕES: Este trabalho permite inferir que a incidência de amputação de membros inferiores foi maior no sexo masculino e teve como principal causa a doença aterosclerótica, mas apresentou uma redução progressiva.
BACKGROUND: There are no precise data on the number of amputations performed every year. However, the decrease in quality of life of patients submitted to amputation is well-known, as is the need to involve a multidisciplinary team in the rehabilitation of these individuals. OBJECTIVE: To analyze all lower limb amputations performed by the Angiology and Vascular Surgery at Hospital Universitário Regional de Maringá, from 2000 to 2006. METHODS: A descriptive and retrospective study was performed to review medical records of patients submitted to amputation or surgical debridement of lower limbs to treat vascular diseases or trauma. RESULTS: A total of 116 procedures were carried out (84.5 percent amputations and 15 percent debridements) in 111 patients; 78 were males and 33 were females, with a mean age of 63.4 years (4-100 years). The main etiological factors were vascular diseases (92.8 percent) and trauma (7.2 percent). The most prevalent comorbidities and risk factors were hypertension (66 percent), diabetes mellitus (60 percent), tobacco (28 percent) and cardiac arrhythmia (0.9 percent). As to schooling, 52.2 percent of the patients had complete elementary school, 6.5 percent had complete or incomplete high school, and 41.3 percent were illiterate. Primary amputation was performed in 94.9 percent of patients, and secondary amputation in 5.1 percent. However, there was a progressive reduction in amputation rate at each year. CONCLUSIONS: Incidence of lower limb amputation was greater in males, had atherosclerotic disease as its main cause, but had progressive reduction.