Résumé
OBJECTIVE: To study the tissues distribution of lung targeting Doxorubicin microspheres in mice. METHODS: doxorubicin microspheres were prepared by emulsification-linkage method, and their characteristics was studied. The tissue distribution of doxorubicin microspheres was investigated via caudal vein injection in mice by high performance liquid chromatography. And the targeting character of microspheres was evaluated. RESULTS: Doxorubicin microspheres were orange and regular. Microspheres with diameters of 5 - 15 μm occupied 85.5%, and the loading amount was 4.05%. The re, te and Ce of doxorubicin microspheres was 2.21 times, 1.97 -3.36 times and 1.68 times larger than those of doxorubicin control solution. And the tissue section also indicated that there were more microspheres in the lung tissue. CONCLUSION: Doxorubicin microspheres can target at the lung tissue of miceand reduce the accumulation in heart, which can improve curative effects and reduce toxicity. Copyright 2012 by the Chinese Pharmaceutical Association.