ANTITUMOR EFFECT OF SOME COMPOUNDS WITH UNSATURATED LACTONE FROM MARINE NATURAL PRODUCTS / 中国海洋药物

The compounds (8R23, 9R221 , 9R6222, 10R221 , H1105) extracted from the soft coral, with unsaturated lactone, showed antitumor effect on EAT, IC50 was 18. 6,85. 8,67. 8,3d. 9, 3.05umol. L-1, respectively; IC50 on S180 was 10. 7,44. 4,30. 9,9. 95,2. 4umol. L-1, respectively. 8R23, 10R221 obviously increased the level of cAMP in the EAT cell. 8R23, 10R221 , III 105 also inhibited DNA synthesis of the EAT cell.These results indicated that these compounds might have antitumor effect, but the mechanism was unknown.