Résumé
【Objective】To observe the therapeutic effect of oral use of Neiyi Pill(composed of Radix Salviae Miltiorrhizae,Sanguis Draxonis,Rhizoma Sparganii,Rhizoma Curcumae,Semen Persicae,Radix Notoginseng,Radix Angelicae Sinensis,Ramulus Cinnamomi,Rhizoma Cyperi,Radix Achyranthis Bidentatae,etc.) combined with enteroclysis of Neiyi Enema(composed of Radix Salviae Miltiorrhizae,Sanguis Draxonis,Semen Persicae,Rhizoma Curcumae,Radix Paeoniae Rubra,Rhizoma Polygoni Cuspidati,etc.) for dysmenorrhea induced by endometriosis(EMS).【Methods】Fifty-eight patients diagnosed as endometriosis by laparoscopy were divided into 3 groups by randomized single-blind method.Group A(n=16) was treated with Neiyi Pill orally,Group B(n=24) with Neiyi Pill orally combined with enteroclysis of Neiyi Enema and Group C(n=18) with danazol orally.The 3 groups respectively received the corresponding treatment for 3 successive menstrual cycles(MC).Dysmenorrhea scoring was carried out according to the Guide for Clinical Research of New Chinese Herbal Medicine before treatment and after 1,2 and 3 menstrual cycles.The effects on symptoms of dysmenorrhea,lumbosacral discomfort and irritative symptom of rectum,signs of tenderness and nodule in posterior fornix of vagina and adnexal masses,and syndrome of blood stasis were observed.Meanwhile,the adverse reactions were also monitored.【Results】After treatment,effect on relieving dysmenorrhea in group B was superior to that in group C(P0.05).Effect on lumbosacral discomfort and syndrome of blood stasis in groups A and B was superior to that in group C(P0.05).Effect on irritative symptom of rectum,tenderness and nodule in posterior fornix of vagina and adnexal masses in group B was superior to that in group C(P0.05).【Conclusion】Oral use of Neiyi Pill combined with enteroclysis of Neiyi Enema has a better effect for endometriosis than only oral use of Neiyi Pill only or danazol,and has no obvious adverse reactions.
Résumé
[Objective] To study the influence on humoral immunity and ectopic endometrium by infusion of Bushen Tiaojing Decoction (BTD) with the Huoxue Sanjie Suppository (HSS) in anus. [Methods] One hundred and thirty SD rats were allocated to ten groups: normal control (A), model (B), normal dose of HSS (C), normal dose of BTD with HSS (D), 3 doses of BTD (E), 3 doses of BTD with HSS (F), 5 doses of BTD (G), 5 doses of HSS (H), 5 doses of BTD with HSS (I), and Danazol (J) groups. The endometriosis (EM) rats were modeled by endometrium implantation in all groups except those in Group A. Four weeks after the treatment, the contents of immunoglobulin (IgG、IgM、IgA), C_3, C_4 and ALT were tested, and histomorphomological analysis of the thymus, ovary, uterus, EM implants, liver and kidney were performed. [Results] Four weeks after EM implantation, the ectopic endometria were growing well, IgG and C_3 increased, but IgM decreased, and the uterus and ovary significantly enlarged. With the treatment of BTD and HSS or Danazol, the ectopic endometria were atrophied. In Groups F and G, IgG decreased; in Groups H and I, C_3 decreased, and uterus and ovary shrunk in Group I. Danazol can help to prolong the sexual cycle, while BTD and HSS can not. In all the medication groups, no obvious difference was found in ALT of the rats. [Conclusion] Oral administration of BTD with HSS can cause endometrial atrophy and improve humoral immunity in model rats.