Résumé
OBJECTIVE:To compare the relative bioavailability of 2 kinds of domestic oxaprozin enteric tablets.METHODS:20 healthy volunteers were administered with single oral dose of trial tablet 400g and reference tablet 400g by crossover design,whose plasma oxaprozin level was determined by HPLC.The pharmacokinetic parameters and bioavailability of oxaprozin enterosoluble tablets were calculated by 3p97 software.RESULTS:The pharmacokinetic parameters of tested enteric tablets vs.reference tablets were as follows,t 1/2?(73.468?24.354),(73.556?24.406)h,t max(13.275?8.012),(13.200?15.154)h,C max(44.283?7.535)、(45.429?15.107)?g/ml,AUC 0～Tn(4471.792?1387.724),(4234.328?1741.380)(?g?h)/ml,AUC 0～inf(5040.407?2092.744),(4858.292?2423.656)(?g?h)/ml;No significant differences were noted between 2 tablets.The relative bioavailability of tested tablet was(112.8?38.5)%.CONCLUSION:2 kinds of oxaprozin enterosoluble tablets were bioequivalent.
Résumé
OBJECTIVE:To study the pharmacokinetics of sinomenine enteric tablet in Beagle dogs. METHODS:A single oral 1d2o0se, o2f4 01,0 mangd? 4k8g0-1 msiinno imn epnliansem ean tsearmicp tlaeb(le2t wmaLs) gwiveerne tdoe t8e rBmeiangelde bdyo gHs.P TLhCe. Tcohnec epnhtarramtioacno okfi nseitnico mpeanrainmee taetr s0 ,w1er5e, c3a0lc,u6la0t,ed9 b0,y 3p97 pharmacokinetic program. RESULTS:The concentration-time curves of sinomenine fitted to one-compartment model in the (adn8odg7 s.6e. l2iTm?hien2 a8mt.i2oa6ni)n i nmp hiBnae;ramgAalUec oCdko0i～gnTse:.t(ic 2p8a.4ra3m?e3te.4rs8 )w?erg?e masi n?fomlloLw-s1.: CtOmaNx:C(L6U9S.6I6O?N:16S.i4n1o)memniinn;e eCnmtaex:ri(c 0ta.b1l3e?ts s0h.0o2w)ed? gra?pimd La-bs1o;rpt1t/i2oke:n