Résumé
Background: Mucormycosis has emerged as an epidemic within the COVID-19 pandemic due to widespread use of corticosteroids and immune-modulators like Tocilizumab, in the management of COVID-19 pneumonia. It is an invasive fungal disease which spreads by angioinvasion and rapidly spreads to adjacent tissues. If untreated its outcomes are dangerous and often fatal. Uncontrolled diabetes, malignancies and dialysis are predisposing factors. Raised blood iron is an important factor in pathogenesis and rapid progression of fungal invasion that needs to be investigated. Aim: To establish a correlation between raised serum ferritin level and aggressiveness of Mucormycosis. Methodology: Aretrospective study was done from February 2021 to February 2022 of patients diagnosed with mucormycosis by middle meatal biopsy and microscopy along with CT& MRI scan of PNS with brain. They were treated either surgically or conservatively. All the blood parameters including serum ferritin level, were carried out. Acomparison was done on extent of disease in patients in-relation to their serum ferritin level. Results: Our study suggested that higher levels of ferritin are often associated with aggressive form the disease. Zygomycetes are dependent on environmental iron for their growth. Higher the serum ferritin level, more aggressive & widespread is mucormycosis. Conclusion: Serum free iron aggravates mucormycosis. Measures should take to control the serum ferritin in patients under risk for mucormycosis. Iron chelating agents or novel methods like anti-ftr1 immune serum should be developed for controlling the disease at its earlier stages
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【Objective】 We performed a prospective analysis of iron status in plateletpheresis donors, to provide data basis and support for optimizing the strategy of plateletpheresis donation and high quality service for donors. 【Methods】 Plasma ferritin levels were measured in samples from 3 444 plateletpheresis donors who donated in Beijing Red Cross Blood Center to evaluate iron status from the perspective of sex, age, donation status and number of donations in the past 12 months. 【Results】 1) The incidence of low ferritin level was 26.63% in 3 444 cases. There was significant difference in the incidence of low ferritin between sex, as 26.75% in males and 26.31% in females (P>0.05), respectively. There was no significant difference in the concentration of ferritin and the incidence of low ferritin between different age groups of first-time donors. The concentration of ferritin declined and the incidence of low ferritin in males and females increased along with accumulated donations during the past 12 months. 【Conclusions】 This is a large study of ferritin testing in Chinese plateletpheresis donors from multiple dimensions, which laid a foundation for further researches. Ferritin screening is necessary and helpful to reduce the risk of iron deficiency in plateletpheresis donors.
Résumé
Background: Febrile seizures are one of the common reasons for emergency room visits in pediatric population affecting up to one in twenty children in various parts of the world. Though febrile seizures are commonly benign it is a source of major family distress and anxiety. Aim of the study: To compare serum ferritin level in simple and complex febrile seizures among children. Materials and methods: This case-control study was conducted at the Department of Pediatrics, Tirunelveli Medical College Hospital, Tirunelveli, from 2017-2018. All cases of febrile seizures which include both simple febrile and complex febrile seizures between the age group of 6 and 60 months were studied. Serum ferritin was estimated by the Ferritin-Turbilatex, by LAB KIT, CHEMEX, S.A. semi auto analyzer. Results: The mean average serum ferritin level in simple febrile seizures was 22.76. The mean average serum ferritin level in complex febrile seizures was 24.72. Hence, it was statistically significant that low serum ferritin is present in those with simple febrile seizures. Conclusion: Iron deficiency anemia was more frequent among children with febrile seizures than those with febrile illness alone. The result suggests that Iron deficiency anemia may be a risk factor for febrile seizures. Thus screening for IDA should be considered in children with febrile seizures. Fever can worsen the negative effect of iron deficiency anemia on the brain and a seizure can occur as a consequence. This suggests that iron-deficient children are more prone to febrile seizures.
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Background: Hypothyroidism is the most common pregnancy-related thyroid disorder, affecting 3– 5% of all pregnant women. Pregnant women are often iron deficient, and iron deficiency has adverse effects on thyroid metabolism. Impaired maternal thyroid function during pregnancy may cause neurodevelopmental delays in the offspring. Iron deficiency is frequent during the first trimester of pregnancy and associated with a higher prevalence of thyroid autoimmunity, higher serum TSH and lower fT4 levels. Anemia is a decrease in the number of red blood cells (RBC's) or less than the normal quantity of hemoglobin in the blood. Anemia can have several reasons, such as abnormality of the formation and reduction on the half-life of the red cells. Aim of the study: To evaluate the thyroid status in second-trimester antenatal cases. Materials and methods: Totally 60 female patients were included in the study. Group-1(30) pregnant women with hypothyroidism. Group -2(30) pregnant women without hypothyroidism. The study was conducted from July – November 2018 over a period of 6 months at OG Department of DSMCH, perambalur. Ferritin levels were estimated in 60 female patients newly diagnosed patients of hypothyroidism using chemiluminescence technique (advia centaur cp). Total T3 and T4 levels were estimated using radioimmunoassay. Free T3, T4, and thyroid-stimulating hormone (TSH) levels were estimated using chemiluminescence. These were then compared with age- and sex-matched healthy controls. Results were correlated statistically. Results: Serum ferritin levels were found to be significantly reduced in pregnant women with hypothyroidism compared to normal pregnant women (p < 0.001). Conclusion: Complications that may occur during pregnancy and delivery could be due to low thyroid function, but was not able to be clearly proven in this study. Although prior or early- Nageshwari A, G. Kavitha. To evaluate the influence of ferritin on thyroid hormones in second trimester antenatal cases in Perambalur District. IAIM, 2019; 6(1): 30-34. Page 31 pregnancy testing for iodine level and thyroid function can help early identify iodine deficiency and thyroid disorder, justifying a general screening will require further studies with multicentrerecruitment and ante-natal clinics involvement
Résumé
BACKGROUND: Heart failure resulting from myocardial iron deposition is the most important cause of death in beta-thalassemia major (TM) patients. Cardiac T2*magnetic resonance imaging (MRI), echocardiography, and serum ferritin level serve as diagnostic methods for detecting myocardial iron overload. In this study, we aimed to evaluate the relationship between the above-mentioned methods. METHODS: T2*MRI and echocardiographic measurement of left ventricular (LV) systolic and diastolic function were performed in 63 patients. Serum ferritin level was measured. The relationships between all assessments were evaluated. RESULTS: There were 40 women and 23 men with a mean age of 23.7+/-5.1 years (range, 15-35 years). There was no statistically significant correlation between serum ferritin level and LV systolic and diastolic function (P=0.994 and P=0.475, respectively). T2*MRI results had a significant correlation with ferritin level; 63.6% of patients with serum ferritin level >2,000 ng/mL had abnormal cardiac MRI, while none of the patients with ferritin level <1,000 ng/mL had abnormal cardiac MRI (P=0.001). There was no significant correlation between MRI findings and LV systolic function (P=1.00). However, we detected a significant difference between LV diastolic function and cardiac siderosis (P=0.03) CONCLUSION: MRI findings are a good predictor of future cardiac dysfunction, even in asymptomatic TM patients; however, diastolic dysfunction may happen prior to cardiac siderosis in some patients, and echocardiography is able to diagnose this diastolic dysfunction while T2*MRI shows normal findings.