Correlation between the cord blood concentarion of leptin and maternal, placental, fetal factors in uncomplicated singleton pregnancy / 대한산부인과학회지

OBJECTIVE: Umbilical leptin concentrations have been associated with whole-body mineral content, fetal bone growth stimulation, pulmonary development in utero, nutritional intake, energy metabolism, and adiposity in children and adults. In this study, we investigated the effect of maternal factor, placental factor and fetal factor on cord blood leptin concentrations. METHODS: We measured leptin concentration in umbilical cord blood using immunoradiometric assay in 50 women with uncomplicated singleton term pregnancies. we analyzed the correlation of leptin level with maternal age, sex, gestational age, smoking, placental weight, neonatal body mass index, maternal body mass index, head circumference, and chest circumference by simple linear regression. RESULTS: There were significant correlation between leptin and gestational age, fetal BMI, head circumference, and chest circumference with correlation coefficient 0.244 (P=0.010), 0.182 (P=0.030), 0.243 (P=0.011), and 0.228 (P=0.014), respectively in the male neonates. There were significant correlation between leptin and fetal BMI with correlation coefficient 0.341 (P=0.003) in the female neonates. No statistically significant correlation between the concentration of leptin and neonatal gender was observed, in spite of higher mean value of female leptin concentration level. Also no statistically significant correlation between the concentration of leptin and smoking and drinking of mother was observed. CONCLUSION: In this study, leptin is significantly correlated with maternal age, maternal BMI, gestational age, fetal BMI, and chest circumference. It was suggested that leptin level was more associated with maternal factor and fetal factor than placental factor.

Clinical Study on Intrauterine Fetal Growth Restriction / 대한주산의학회잡지

This study was undertaken at the department of Obstetrics and Gynecology, Chonnam University Medical School, to investigate the association between some of the risk factor and the incidence of intrauterine fetal growth restriction(IUGR). The studied population was selected from patients who admitted at Chonnam University Hospital during January, 1992 through May, 1997, with following criteria, Korean, singletone pregnancy with live birth and known gestational weeks with 28 or more. And then, the risk factors were analyzed in terms of maternal factor, placental factor, and fetal factor. The following results were obtained. 1) The incidence of IUGR was 6.1%. 2) The incidence of IUGR was higher at young aged mother and nullipara. 3) Only 39.1% of etiologic factors for IUGR was found to have known causes. According to the risk factors for IUGR, hypertensive disorder during pregnancy, anemia, cardiac disease, leukemia, and pulmonary tuberculosis were associated with increased incidence of IUGR. 4) The relative risk of IUGR was much higher in neonates born with congenital anomalies. 5) According to the placental causes of IUGR, placenta previa and placenta abruption showed some association with IUGR.

Intrauterine Depressed Skull Fracture of the Newborn associated with Skull Capillary Hemangioma

Authors experienced one case of intrauterine depressed skull fracture which associated with skull capillary hemangioma. In reviewing literatures, there are two types of intrauterine skull depression, traumatic and spontaneous. Pressure of the fetal head against maternal bony structures accounts for most of the so-called spontaneous type. Authors case was spontaneous type and associated with "fetal factor", congenital capillary hemangioma of the skull.

Intrauterine Depressed Skull Fracture of the Newborn associated with Skull Capillary Hemangioma

Authors experienced one case of intrauterine depressed skull fracture which associated with skull capillary hemangioma. In reviewing literatures, there are two types of intrauterine skull depression, traumatic and spontaneous. Pressure of the fetal head against maternal bony structures accounts for most of the so-called spontaneous type. Authors case was spontaneous type and associated with "fetal factor", congenital capillary hemangioma of the skull.