Evaluation of FNAC in Bone Lesions

The aim of the present study is to evaluate the utility of FNAC in diagnosing bone lesions especially bone tumours. Methods: A total of 120 cases were selected from patients attending OPD and admitted in IPD in MLB Medical College, Jhansi, presenting with complaints of swelling arising from bone. FNAC of the lesion was performed, with guidance of X-Ray reports when available, clinical details, history of present illness & other physical findings have also been noted, and considered while making the diagnosis, and the findings were compared with that of histolgical specimen whenever available. Results: The present study includes 355 malignant cases, of which 53.8% are primary neoplasms, 7.6% are metastatic lesions, and 38.4% are locally malignant lesions. The most common primary bone malignancy in this study is Osteosarcoma. Comparison of Cytological and Histological Diagnosis in all cases was done. 39 malignant lesions were reported on Cytological basis and all 39 were found correct on histological correlation, while 18 out of total 21 benign lesions were diagnosed correctly, as confirmed by subsequent histological examination. Out of total 51 inflammatory lesions 42 were diagnosed correctly, 9 aspirations were found inadequate for reporting. Conclusion: Fine Needle Aspiration Cytology (FNAC) is a very valuable procedure in patients with bone lesions. The complications are almost nil, the cost is very low, is minimally painfull, is an OPD procedure and informative reports are available within 12-48 hours.

Study of AgNOR count in FNAC of breast lesions.

Background:ArgyrophilicNucleolar Organizer Region technique has a potential value in the diagnosis of malignancy and can be used in cases with equivocal and inconclusive cytological picture. The purpose of this study was to evaluate mean ArgyrophilicNucleolar Organizer Region count and ArgyrophilicNucleolar Organizer Region Pattern Assessment score in fine needle aspirates of breast lumps.Materials and Methods: The present study consists of 80 cases of AgNOR count done in fine needle aspiration cytology of various breast lesions in patients on O.P.D. basis or those admitted in Guru Govindsingh Hospital attached to Shri M.P. Shah Medical College, Jamnagar during the period between August '98 to May 2000. Fine Needle Aspiration smears were studied by conventional methods and silver staining for ArgyrophilicNucleolar Organizer Regions. Histopathologic diagnosis was taken as the gold standard. Results:ArgyrophilicNucleolar Organizer Region count and ArgyrophilicNucleolar Organizer Region Pattern Assessment score were helpful in differentiating benign from malignant lesions. Mean ArgyrophilicNucleolar Organizer Region count and ArgyrophilicNucleolar Organizer Region Pattern Assessment score were 2.63 ± 1.36 and6.26 ± 1.19 respectively in benign lesions while they were 8.42 ± 2.53 and 10.05 ± 2.22 respectively in malignant lesions.With few exceptions, cases with high counts had high scores. Conclusion: Mean ArgyrophilicNucleolar Organizer Region AgNOR count and Subjective ArgyrophilicNucleolar Organizer Region Pattern Assessment score provide useful information regarding cellular proliferation. Both count and score have comparable diagnostic potential but the latter is a more convenient and rapid method for ArgyrophilicNucleolar Organizer Region evaluation.