Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 2 de 2
Filtre
Ajouter des filtres








Gamme d'année
1.
Psychiatry Investigation ; : 75-80, 2013.
Article Dans Anglais | WPRIM | ID: wpr-34815

Résumé

OBJECTIVE: Patients with schizophrenia who are treated with aripiprazole experience some benefits including an improvement of social competence, but the underlying mechanism of this improvement has not been investigated yet. This study aimed to provide preliminary evidence that the GABA system may be involved in the effect of aripiprazole on social competence. METHODS: Seventeen outpatients with schizophrenia (9 taking aripiprazole and 8 taking risperidone) and 18 healthy controls underwent 18F-fluoroflumazenil PET, and GABAA receptor binding potential was compared between the three groups. RESULTS: Voxelwise one-way ANOVA showed that GABAA receptor binding potentials in the right medial prefrontal cortex (p=0.04) and right dorsolateral prefrontal cortex (p=0.02) were significantly lower in the aripiprazole group than the risperidone group, and those in the left frontopolar cortex (p=0.03) and right premotor cortex (p=0.02) were significantly lower in the aripiprazole group than the risperidone and control groups. CONCLUSION: Our results suggest that aripiprazole administration results in increased GABA transmission in the prefrontal regions, and that these increases may be a neural basis of aripiprazole's clinical benefits on an improvement of social competence.


Sujets)
Humains , Acide gamma-amino-butyrique , Capacité mentale , Patients en consultation externe , Pipérazines , Cortex préfrontal , Quinolinone , Rispéridone , Schizophrénie , Aripiprazole
2.
Journal of Korean Epilepsy Society ; : 89-103, 2002.
Article Dans Coréen | WPRIM | ID: wpr-173991

Résumé

No abstract available.


Sujets)
Électrons , Épilepsie , Tomographie par émission de positons
SÉLECTION CITATIONS
Détails de la recherche