Dementia in motor neuron disease: reviewing the role of MRI in diagnosis / Demência em doença do neurônio motor: revisão do papel da RM no diagnóstico

ABSTRACT The superimposed clinical features of motor neuron disease (MND) and frontotemporal dementia (FTD) comprise a distinct, yet not fully understood, neurological overlap syndrome whose clinicopathological basis has recently been reviewed. Here, we present a review of the clinical, pathological and genetic basis of MND-FTD and the role of MRI in its diagnosis. In doing so, we discuss current techniques that depict the involvement of the selective corticospinal tract (CST) and temporal lobe in MND-FTD.

RESUMO As características clínicas sobreposta da doença do neurônio motor (DNM) e demência frontotemporal (DFT) compreendem um distinto ainda não totalmente compreendido, base neurológica síndrome de sobreposição clínico-patológico foi recentemente revisto. Aqui, apresentamos uma revisão das bases clínicas, patológicas e genética de DNM-DFT e o papel da ressonância magnética no diagnóstico STI. Ao fazê-lo, discutimos as técnicas atuais que retratam o envolvimento do trato corticoespinhal seletiva (TCS) e lobo temporal em DNM-DFT.

A Patient of Parkinsonism Combined with Frontotemporal Dementia

Frontotemporal dementia as subtype of Frontotemporal lobe dementia is a neurological disorder characterized by personality changes, deteriaoration of memory and executive functions as well as stereotypical behaviour. Parkinsonism was sometimes associated with other degenerative disease, such as Alzheimer disease. However, Parkinsonism accompanied with frontotemoporal lobe dementia had hardly been described. We report a 68 year-old man with pakinsonian symptoms associated with frontotemporal dementia. He complainted personality change, other cognitive disorder with sparing memory function, bradykinesia, postural instability, stooped posture, and gait disturbance.

A Case of Frontotemporal Lobe Dementia

Frontotemporal lobe dementia have been underevaluated because of various clinical features, changing diagnostic criteria, and indifference of clinicians. It is important that frontotemporal lobe dementia patient showing behavioral and lingual problems should be early diagnosed and treated. Because frontotemporal lobe dementia patients often confused with Alzheimer's disease, senile depression, schizophrenia, drug abuse. We have presented a case of frontotemporal lobe dementia. He had typical clinical history and symptoms which deserve to be considered frontotemporal lobe dementia. He showed appropriate findings of frontotemporal lobe dementia in the neuropsychological tests and brain magnetic resonance imaging and single photon emission computed tomography. This case is thought to be helpful for clinicians to give attention to early diagnosis and appropriate treatment of frontotemporal lobe dementia.