Apolipoprotein A-1 as a Factor to Assess Recovery of the Liver Function after Hepatectomy and Liver Transplantation

PURPOSE: The aim of this study is to determine whether the serum apolipoprotein A1(apoA1) level, as measured at different time points after hepatectomy and liver transplantation, can predict the synthesis ability of the liver and the nutritional status. We also investigated the usefulness of regions of interest(ROIs) as an indicator of the recovery status of the liver after liver transplantation. METHODS: 93 patients (21: laparoscopic cholecystectomy, 53: partial hepatectomy, 19: liver transplantation) were operated on under general anesthesia. The serum levels of apoA1, prealbumin, albumin, aspartate aminotransferase and alanine aminotransferase and the prothrombin time were measured at pre- and post-operation. The liver conditions were a normal liver (50 cases), hepatitis (16 cases) and liver cirrhosis (28 cases). The mean hepatic attenuation was calculated by averaging the ROI values that were obtained at different hepatic segments. RESULTS: The serum apoA1 level was minimally changed during the perioperative period in the laparoscopic cholecystectomy group. Yet in most cases, the serum apoA1 level after partial hepatectomy and liver transplantation was decreased on postoperative days (PODs) 1 and 7, but it nearly recovered to the preoperative level on POD 30. There were significant differences in the values of apoA1 between the normal liver and co-existent liver disease at the various time points. The ROI value after transplantation gradually increased and it reached a normal level by POD 30. CONCLUSION: The serum apoA1 level can be an indicator of liver's ability to synthesize protein and the nutritional status after partial hepatectomy. In addition, ROIs of the unenhanced CT image can reflect the recovery status of the liver after transplantation.

EFFECTS OF MALOTILATE ON ACUTE LIVER INJURY INDUCED BY CARBON TETRACHLORIDE AND D-GALACTOSA-MINE IN MICE / 中国药理学通报

A study was made; of the effect of malotilate on the acute liver injury induced by carbon tetrachlorid,e ( CC14 ) and d-galactosamine in mice. Malotilate ( 50~150mg/kg ig?3 ) significantly inhibited the elevation of serum glu tamic pyruvic transaminase ( SGPT ) in CC14- intoxicated mice.At the dose of 100mg/kg ig?3, malotilate remarkably increased the content of hepatic glycogea in CCl4-injected mice. The contents of serum protein, liver protein, and cytochrom P-450 in liver hemogenate were increased by malotilate ( 100mg/kg ig?3) in CC14-intoxicated mice. The drug also reduced the accumulation of liver triglycerides induced by CCl4 in mice.In addition to, malotilate(50mg /kg, ip?5) could act against the increase of SGPT and the decrease of liver protein content induced with d-galactosamine in mice. These results suggest that malotilate may be a new therapeutic agent for liver injury.

Preventive and Curative effects of Bee Pollen of Codonopsis Pilosula Nannf on Chronis hepatic injury by CCl_4 / 昆明医科大学学报

During the period of the subcutaneous injection of CCl_4 0.5ml/kg, four times at intervals of 5 days, the C57 mice were fed with 6.8％ bee pollen of Codonopsis Pilosula Nannf (BPCPN). The results showed that BPCPN coule alleviate effctively the hepatic injury induced by CCl_4, and prevent the decrease of serum albumin and liver protein and glycogen after the liver was injured. The electron microscopis and pathologcal examination also showed that the mice had only slight hepatic necrosis, fat degeneration and fibrosis, but had a com plete repair as compared with the control groups. The above results indicated that BPCPN possessed preventive and curative on the impairment of CCl_4and could protect the hepatic metabolic function from the injury of CCl_4.