Résumé
Through the clinical research information sharing system,this study was aimed to explore the law of Professor Shen Zhongyuan's treatment of hepatitis B liver cirrhosis,and to inherit academic thoughts of senior famous traditional Chinese medicine (TCM) doctors.The structured electronic medical record system was used.The information of Professor Shen Zhongyuan expert outpatient with hepatitis B cirrhosis was collected from September 2012 to September 2015.And then,the medical data were extracted and analyzed to find out the medication regularity of hepatitis B cirrhosis and the distribution rule of the taste tropism of herbal medicine in the treatment.The results showed that 388 cases of hepatitis B cirrhosis patients with a total of 127 kinds of herbal medicine.The cumulative using frequency of herbal medicine was 5595.The most commonly used 10 types of Chinese medicine were turmeric,citrus aurantium,cuttlefish bone,atractylodes,rhizoma coptidis,salvia miltiorrhiza,lobelia,artemisia capillaris,fructus trichosanthis,and chicken's gizzard-membrane.The taste of mostly used Chinese medicine is bitter and sweet,followed by acrid.The nature of Chinese medicine is cold,slightly cold,warm and even.The meridian tropism of Chinese medicine is mainly to the liver and spleen meridian.It was concluded that Professor Shen in treatment of hepatitis B cirrhosis drug laws was often to use heat-clearing and toxin-relieving,qi-reinforcing and spleen-invigorating medicine,liver-soothing and qi-regulating medicine,blood-activating and stasis-removing medicine.The nature of herbal medicine used is mostly cold,slightly cold,warm and even.It is based on the TCM syndrome differentiation and treatment thought of “regulating yin-yang to maintain the balance.” It showed the important principle of “toxin-removing,stasis-removing,liver-regulating and spleen-strengthening” by professor Shen.
Résumé
Objective To investigate the clinical efficacy of umbilical blood stem cell transplantation (UCBSCT) on the treatment of hepatitis B liver cirrhosis. Methods Forty-eight patients with hepatitis B liver cirrhosis were enrolled and divided into the treatment group and the control group. There were 25 patients in the treatment group , who received UCBSCT treatment based on conventional liver protection treatment and 23 patients in the control group , who received conventional liver protection treatment. The changes of liver function , coagulation function, clinical symptoms, signs and side effects were studied before the treatment and at 2, 4, 12 and 24 weeks post-treatment. Results The levels of albumin, cholinesterase, and prothrombin activity in the treatment group were higher than those before treatment and were higher than those in the control group. The parameters in the control group were not significantly changed before and after the treatment (P > 0.05). The levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin in both two groups were not significantly changed before and after the treatment (P > 0.05). After 4-week treatment,the differences on improvement of appetite , lacking in strength , abdominal distension , ascites were statistically significant in the treatment group compared with the control group (P < 0.05). No adverse reactions were observed in all groups. Conclusion UCBSCT on the treatment of hepatitis B liver cirrhosis is safe and reliable.