A Retrospective Study of Clinicopathological Profile and Treatment Outcomes of Thyroid Malignancies Presented to a Tertiary Care Teaching Hospital

Introduction: Thyroid cancer is on the developing world over– almost doubling in the past ten years. This is mainly due toimproved awareness, screening and diagnosis of the nodulardisease. Thyroid cancer has an apparent gender predispositionwith women being affected three times more than men and8th most mostly occurring cancer among women. To analyzethe clinicopathological profile of thyroid cancer patients andto assess the pattern of treatment and long-term treatmentoutcomes.Material and methods: The current study was retrospectivecase record review of all the thyroid cancer cases includingall the histopathological confirmed cases of thyroid cancer.The statistical analysis was carried out by using IBM SPSSversion 21.Results: A total of 67 subjects were included with a meanage of 44.72 ± 14.99 years. Females were 68.66% andmales 31.34% of the study population, 61 (91.05%) peoplehad usual presentation of neck swelling of various sizes andother associated findings. Thyroid function test showed that91.04% (61) showed euthyroid status, 40.3% (27) had a totalthyroidectomy, 95.52% (64) of the patients were alive andwell.Conclusion: The study bears evidence to the fact thatpapillary carcinoma is the most commonly occurring formof differentiated thyroid cancer (70.6%). The prevalence ofdistant metastasis is 4.48% and most commonly found in thelung. The disease is more prevalent among women than men

Ablation of Remnant Thyroid Tissue with I-131 in Well Differentiated Thyroid Cancer After Surgery / 대한핵의학회잡지

To evaluate the effectiveness of I-131 in ablation of residual thyroid tissue, we analyzed 350 patients with thyroid cancer who were treated with various doses of I-131 after surgery for thyroid cancer. Two hundred fifty five patients were treated with l.lGBq(30mCi) of I-131 for ablation of remnant thyroid and one hundred seventeen patients received more than 2.8GBq(75mCi) of I-131. We determined the effectiveness of ablation by following I-131 whole body scan. Absent visible uptake or minimal uptake in thyroid tissue were considered as successful ablation. Of 255 patients who received doses of 30mCi I-131 therapy, 131 patients(51%) showed successful ablation of residual thyroid tissue with 2.6+/-1.7 times of I-131 therapy. Of 117 patients who received doses of the more than 75mCi I-131, 84 patients(72%) had successful remnant thyroid ablation with 1.6+/-1.1 times of I-131 therapy. According to the extent of surgery, successful ablation rates were 78%, 62%, 54%, 33% in patients who underwent total thyroidectomy, subtotal thyroidectomy, lobectomy and isthmectomy, lobectomy or tumorectomy, respectively. This study showed that ablation of remnant thyroid after surgery with 30mCi I-131 was successful only in 50%. Therefore, in cases of patients with high risk for recurrence, we recommend high dose I-131 for ablation of remnant after total thyroidectomy.