Relationship between preoperative biochemical indexes and effect of postoperative first 131I internal irradiation for differentiated thyroid carcinoma / 中国医师进修杂志

Objective To analyze the relationship between preoperative biochemical indexes and effect ofpostoperative first 131I internal irradiation for differentiated thyroid carcinoma. Methods One hundred and eighty patients of thyroid carcinoma within the first 131I internal irradiation postoperative. According to curative effect were divided into effective group (96 cases) and invalid group (84 cases) and their clinical data were retrospectively analyzed. Results The preoperative serum alkaline phosphatase (AKP) and thyroid-stimulating hormone (TSH) in effective group and invalid group were respectively (74.83 ± 19.77),(65.50 ± 11.84) U/L and (3.12 ±0.59), (2.57 ±0.56) mU/L. There were significant difference (t =3.77,6.39, P < 0.01) between two groups. Conclusion The levels of preoperative serum A KP and TSH are important factors to influence the effect of postoperative first 131I internal irradiation for differentiated thyroid carcinoma.

Clinical analysis of treatment of ~(131) iodine combined with Jiakangsha oral solution in 230 cases with hyperthyroidism / 中国基层医药

Objective To observe the treatment efficacy in patients with hyperthyroidism by ~(131) radioactive iodine in conjunction with Jiakangshu oral solution.Methods 465 cases with hyperthyroidism were divided into control group(n=235)and treatment group(n=230).In the treatment group on the basis of ~(131) iodine therapy plus service Jiakangshu oral solution.The contents of T_3,T_4,FT_3,FT_4,TSH were observed before and after treatment.Results The cure rate 74.7% in treatment group after treatment 12-month was higher than 65.1%(χ~2=3.94,P＜0.05),total effective rate 88.6% was higher than 80.4%(χ~2=3.90,P＜0.05).The contents of T_3,T_4,FT_3,FT_4,TSH drop,but TSH levels increased in two groups after 12 months with those before treatment(t=2.745,2.778,2.845,2.812,2.833,all P＜0.05).The contents of T_3,T_4,FT_3,FT_4 in treatment group decreased significantly compared with the control group after treatment 12 months(t=2.145,2.178,2.245,all P＜0.05).The negative conversion rate of TGAb,TMAb in the treatment group were significantly higher than control group(χ~2=3.98,3.88,all P＜0.05).Conclusion The treatment effecs are obvious in patients with hyperthyroidism by 131 radioactive iodine in conjunction with JiaKangShu oral solution.