The Early Results for Surgical Treatment of Atherosclerotic Arterial Occlusive Disease in the Ilio-femoral Artery

PURPOSE: To review clinical features and operative results for patients, who underwent surgical treatment. METHOD: A retrospective review of 40 patients who underwent ilio-femoral artery bypasses surgery for ilio-femoral arterial occlusive disease. RESULT: Hypertension (60%) and diabetes (42%) were the most common underlying diseases among the patients according to the result of the patient's records; 35 (87.5%) men and 5 (12.5%) women, the mean age is 63. The operation was done for the patients who have the rest pain (57.5%), and this was followed by claudication (22.5%). The median follow-up period was 25.73 months. The most common occluded site was the superficial femoral artery (62.5%). The most common bypass operation was the femoropopliteal bypass (57.5%). In addition to that, the graft infection was the most common postoperative complication (12.5%). The 1st year and 2nd year primary graft patency rates were 60% and 42%. CONCLUSION: Among the various methods of treatment for the atherosclerotic arterial occlusive disease, bypass surgery is known as the most effective method. Although the early primary patency rates of this analysis were inferior to those of previous reports, a simple comparison was not adequate, because the data of this analysis was not sub-divided according to followings; the sites of occlusion, distal run off, operative indications, operative methods, and etc.

Effects of Tongxinluo Capsule on ET,NO,SOD and MDA in atherosclerosis obliterans rabbits / 中成药

AIM:To explore the dynamic changes of ET,NO,SOD and MDA in atherosclerosis obliterans(ASO) rabbits,as well as the effects of Tongxinluo Capsule(Radix et Rhizoma Ginseng,Hirudo,Scorpio,Eupolyphaga seu Steleophaga,etc.)(TXL) and the candidate mechanisms. METHODS: Rabbits were randomly divided into 7 groups: sham,model,TXL(0.8,0.4,0.2 g/kg),Tongsaimai tablet(0.8 g/kg) and Laishike((0.002 g/kg)).The animal model of ASO was established with a combined method of mechanical trauma,immunologic injury and high fat fodder feeding.Rabbits were administrated the drugs for 8 weeks after surgery.The levels of ET,NO,SOD and MDA were determined at the time points below: pre-experiment,pre-drug administration,4 weeks after drug administration,8 weeks after drug administration,12 weeks after drug administration.The histopathological changes in iliofemoral artery were examined after opacification. RESULTS: TXL significantly extenuated the decrease in the caliber of the iliofemoral artery of the injured hind limb and decreased MDA content while increased SOD activity and NO content in serum. CONCLUSION: TXL might show effects on improving endothelial cell dysfunction,clearing free radicals and antagonizing lipid peroxidation,which might be the candidate mechanisms for the prevention and treatment of TXL for ASO.