Résumé
Astragali Radix is a classic Chinese materia medica with multiple effects including replenishing qi, consolidating exterior, promoting pus and discharge tissue regeneration, inducing diuresis to alleviate edema and other effects. Modern scientific researches have confirmed that different forms of Astragali Radix (single drug and compound) exhibit various pharmacodynamic effects on different pathological diseases, and their material basis are not the same. This review summarized the researches on the material basis of multi-effect Astragali Radix and provided new ideas for the related studies of material basis of Astragali Radix and its formula.
Résumé
Objective:To observe the efficacy of benefiting Qi for warming Yang and activating blood circulation for inducing diu-resis method in the treatment of patients with chronic heart failure( CHF) and its effect on the expression of circulating miRNAs ( miR-423-5p, miR-210-3p). Methods:Totally 80 CHF patients were randomly divided into two groups,the control group with 40 patients was treated with the conventional anti-heart failure therapy, and the treatment group with 40 patients was treated with benefiting Qi for warming Yang and activating blood circulation for inducing diuresis decoction on the basis of the control group, and the treatment course was 2 weeks. The clinical efficacy and syndrome integral of traditional Chinese medicine ( TCM) were evaluated. Left ventricular ejec-tion fraction ( LVEF) and left ventricular end diastolic diameter( LVEDD) were measured by echocardiography;the plasma expression levels of circulating miRNAs(miR-423-5p, miR-210-3p) were measured by real-time PCR in the two groups before and after the treat-ment. The adverse drug reactions were observed as well. Results:The total clinical effective rate of the treatment group was significant-ly higher than that of the control group (87. 50% vs 65. 00%, P <0. 05); the syndrome integral of TCM, indices of LVEF and LVEDD and the expression of circulating miRNAs were improved in both groups(P<0. 05);the total clinical effective rate, syndrome integral of TCM, indices of LVEF and LVEDD and the expression of circulating miR-423-5p of the treatment group were better than those of the control group(P<0. 05); there was no significant difference in adverse drug reactions between the groups (P>0. 05). Conclusion:The benefiting Qi for warming Yang and activating blood circulation for inducing diuresis method can improve the clinical effects in the treatment of CHF, and improve the expression of circulating miRNAs.
Résumé
Objective To observe the effect of the therapeutics of warming Yang and inducing diuresis with removing blood stasis and clearing away turbidness in retarding the course of chronic renal failure (CRF). Methods Sixty-five patients with CRF were randomly divided into the treated group (33 cases) and the control group (32 cases). Both groups were treated with low-protein diets,controlling hypertension and symptomatic treatment. And Chinese drugs for warming Yang and inducing diuresis with removing blood stasis and clearing away turbidness were given additionally to the treated group. The time (month) for doubling serum creatinine (SCr) level was taken to evaluate the speed of CRF progression. Results In the treated group,the time for SCr increased from (300.5?99.2) ?mol/L to (602.0?199.6) ?mol/L was (27.6?9.1) months,while in the control group,the time for SCr increased from (296.3?96.8) ?mol/L to (598.8?198.4) ?mol/L was (17.2?5.7) months. Comparision between the tow groups showed significant difference (P