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Korean Journal of Dermatology ; : 492-495, 2019.
Article Dans Anglais | WPRIM | ID: wpr-759781

Résumé

Immunoglobulin A (IgA) pemphigus is a rare variant of an autoimmune bullous disease with IgA antibodies. IgA pemphigus is divided into 2 major subtypes: the subcorneal pustular dermatosis (SPD) type and intraepidermal neutrophilic (IEN) dermatosis type. We documented a case of an 18-year-old woman with recurrent generalized blisters and pustules that were especially severe in the intertriginous areas. Some half-and-half blisters and coalesced pustules in an annular pattern with crusts were simultaneously observed. A biopsy specimen from one of the half-and-half blister lesions showed intraepidermal separation with multiple neutrophils. Direct immunofluorescence staining revealed lace-like intercellular deposition of IgA in the entire epidermis. IgA antibody deposits were also observed in the patient's serum. The eruptions cleared with systemic steroids and colchicine 0.6 mg for 1 week, and the patient remained in partial remission at the 8-month follow-up. Herein, we report a case of IEN-type IgA pemphigus, clinically mimicking SPD with half-and-half blisters.


Sujets)
Adolescent , Femelle , Humains , Anticorps , Biopsie , Cloque , Colchicine , Épiderme , Technique d'immunofluorescence directe , Études de suivi , Immunoglobuline A , Immunoglobulines , Granulocytes neutrophiles , Pemphigus , Maladies de la peau , Dermatoses vésiculobulleuses , Stéroïdes
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