Connotation of Traditional Chinese Medicine in Treatment of Chronic Obstructive Pulmonary Disease by Regulating Gut Microbiota Based on "Lung and Large Intestine Being Interior-exterior Related" / 中国实验方剂学杂志

Chronic obstructive pulmonary disease （COPD） is a heterogeneous lung condition characterized by persistent and often progressive airflow obstruction， including airway abnormalities （e.g.， bronchitis and bronchiolitis） and chronic respiratory symptoms （e.g.， dyspnea， cough， and expectoration）. It is one of the leading causes of death worldwide. According to the theory of traditional Chinese medicine （TCM）， the lung and large intestine are interior-exterior related. Therefore， COPD can be treated from both the lung and intestine by the methods of tonifying and invigorating lung， spleen， and kidney， dispelling phlegm， and expelling stasis. Gut microbiota plays a key role in human immunity， nerve， and metabolism and may act on COPD by affecting the structures and functions of lung and intestine tissue and regulating lung inflammation and immunity. TCM can restore the balance of gut microbiota， which is conducive to the recovery from COPD. For example， the treatment method of tonifying lung and invigorating kidney can regulate gut microbiota， alleviate pulmonary and intestinal injuries， and improve lung immunity. The treatment methods of dispelling phlegm and expelling stasis can regulate gut microbiota and reduce pulmonary inflammation. According to the TCM theory of lung and large intestine being interior-exterior related， this review elaborates on the connotation of TCM in the treatment of COPD by regulating gut microbiota， aiming to provide new ideas for the clinical treatment of COPD via gut microbiota.

Medication and prescription rules for treating spleen and stomach diseases in Prescriptions of Peaceful Benevolent Dispensary / 数字中医药（英文）

@#【Objective】   To explore the prescriptions related to the treatment of spleen and stomach diseases in Prescriptions of Peaceful Benevolent Dispensary (Tai Ping Hui Min He Ji Ju Fang,《太平惠民和剂局方》, TPHMHJJF), and investigate the medication and prescription rules. 【Methods】   The prescriptions of TPHMHJJF for treating spleen and stomach diseases were screened, and the data set was established by entering the prescriptions and standardized drug names using WPS Excel 2019. Herb frequency statistics, efficacy categorization, property, flavor, meridian tropism, association rules, cluster analysis, factor analysis, and complex network analysis were performed using Python 3.6.8 programming language and Gephi 0.9.2 visualization software. 【Results】   A total of 239 prescriptions were included after the screening, and the dosage forms were mainly pills and powders. The study involved 200 herbal medicines, among which 40 herbs had a frequency of ≥ 12. The herb with the highest frequency was Ganjiang (Zingiber Rhizoma). The herb properties were mainly warm in nature, with the most pungent herbs. Most herbs were attributed to the spleen and stomach meridians, and tonifying medicine were the main species. The association rule analysis identified 26 second-order association rules and 16 third-order association rules, with "Renshen (Ginseng Radix et Rhizoma) → Fuling (Poria)" as the leading rule in the former and "Fuling (Poria) + Baizhu (Atractylodis Macrocephalae Rhizome) → Renshen (Ginseng Radix et Rhizoma)" as the leading rule in the latter. Also, cluster analysis divided the top 30 herbs into six herb combinations that can warm the middle, move Qi, and dry dampness effectively. Factor analysis extracted 13 common factors, with Renshen (Ginseng Radix et Rhizoma), Fuling (Poria), and Baizhu (Atractylodis Macrocephalae Rhizome) as the highest contributing factors. Lastly, complex network analysis yielded the core prescription of 14 herbs, with Ganjiang (Zingiber Rhizoma), Renshen (Ginseng Radix et Rhizoma), Gancao (Glycyrrhizae Radix et Rhizome), and Chenpi (Citri Reticulatae Pericarpium) among the herbs with a higher weighting degree. 【Conclusion】  TPHMHJJF is mainly based on the use of warming herbs to treat spleen and stomach diseases, and its medication rule can be summarized into three aspects: (i) primarily using warming and tonifying to warm the middle and dissipate cold, (ii) using the method of moving Qi with aromatic nature to delight the spleen and appetize the stomach, and (iii) emphasizing the regulation of Qi and blood to calm the five zang-organs.

The incidence of artificial stone-related silicosis among interior decoration workers in different countries / 中华劳动卫生职业病杂志

In this paper, 177 cases of artificial stone-related silicosis in interior decoration workers from Israel, Spain, USA, Italy and Australia were analyzed. Interior decoration workers were from small businesses (or workshops), engaged in kitchen and/or bathroom artificial stone countertops cutting, grinding, polishing and other reprocessing. In the working environment, the content of crystalline silica in artificial stone was more than 70%, and the concentration of silica dust exceeded the relevant standards. Most workplaces used dry cutting without ventilation and dust removal and other dust-proof measures, and most workers did not wear qualified respiratory protective equipment. Taking comprehensive measures such as wet operation, ventilation and dust removal, and individual protection can effectively prevent the occurrence of artificial stone-related silicosis.

Evaluación de la exposición a Hidrocarburos Aromáticos Policíclicos, salud renal y respiratoria en población indígena de Tocoy, San Antonio, S. L. P, México / Evaluation of exposure to polycyclic aromatic hydrocarbons, renal and respiratory health in the indigenous population of Tocoy, San Antonio, S. L. P, México

Resumen La contaminación del aire interior es un problema de salud pública, ya que afecta a unos 2.600 millones de personas en todo el mundo que siguen cocinando con combustibles sólidos como la madera, los residuos de las cosechas, etc. Esta exposición aumenta el factor de riesgo de desarrollo de enfermedades crónicas. La población indígena es muy susceptible a estar expuesta a mezclas de contaminantes del humo de leña como los Hidrocarburos Aromáticos Policíclicos (HAPs) debido a los métodos tradicionales de cocción. El objetivo de este trabajo fue evaluar la exposición a HAPs por medio de 10 metabolitos hidroxilados en orina de la población indígena de la Huasteca Potosina, mediante cromatografía de gases acoplada a espectrometría de masas; por otro lado, la salud renal y pulmonar fueron evaluadas con una prueba general de orina y la toxina urémica Indoxil sulfato, esta fue evaluada por medio cromatografía líquida de alto rendimiento, y la función pulmonar con una espirometría. Los resultados indican la presencia de metabolitos hidroxilados en el 89,47% de las muestras de orina, los más frecuentes fueron el 1-OH-PIRENO, el 1,2-OH-NAFTALENO. El Indoxil sulfato se presentó en el 100% de las muestras y la media era de 193,4 ± 91,85 gg/L En cuanto a la salud pulmonar, los resultados indican que algunos sujetos presentan patrones respiratorios regulares e irregulares. Estos resultados indican que la población se encuentra expuesta de manera crónica a una mezcla de contaminantes en el aire que podría producir el desarrollo de daño en los pulmones y los riñones y aumentar el riesgo al desarrollo de enfermedades crónicas.

Abstract Interior air pollution is a public health concern, it affects about 2.6 billion people around the world who still cook using solid fuels such as wood, crop wastes, among others. This exposition increases the risk of the development of non-communicable diseases (NCDs). The indigenous population is very susceptible to being exposed to mixtures of pollutants from the wood smoke such as Polycyclic Aromatic Hydrocarbons (PAHs) due to traditional methods of cooking, heating and waste burning. Therefore, the objective of this work was to evaluate the exposure to PAHs through the application of 10 hydroxylated metabolites (OH-PAHs) in the urine of the indigenous population from the Huasteca Potosina, this by gas chromatography coupled to mass spectrometry and to assess renal health of the population at the time of the study, with a general test of urine and through the uremic toxin Indoxyl Sulfate (IS), this by high-performance liquid chromatography, and the and pulmonary health with spirometry. The results indicate the presence OH-PAHs in 89.47% of the urine samples, the most frequent metabolites were 1-OH-PYRENE, 2-OH-NAPTHALENE. IS was present in 100% of the samples in mean concentrations of 193.4 ± 91.85 gg/L. For pulmonary health, the results indicate some subjects have regular and irregular respiratory patterns. These results indicate that the population is highly exposed to a mixture of pollutants in the air that might damage the lungs and kidneys and increase the risk of NCDs development.

Biomecánica del pase con borde interno entre futbolistas prejuveniles y juveniles de Formativas y Academia / Biomecânica do passe com bordo interior entre os jogadores de futebol pré-juvenil e juvenil de formação e academia / Biomechanics of the pass with internal edge among prejuvenile and juvenile soccer players of Formative and Academy centers

RESUMEN La biomecánica es una ciencia que ayuda al estudio de los movimientos aplicados en distintos deportes, incluyendo el fútbol, que permite identificar y corregir errores técnicos. Esta es una base fundamental para el control de la preparación del deportista. En tal sentido, se planteó como propósito de la investigación analizar biomecánicamente el pase con borde interno del pie en futbolistas prejuveniles y juveniles de Formativas y Academia. La investigación es de tipo descriptiva-explicativa, de orden correlacional; se diagnostican biomecánicamente a 40 futbolistas en dos grupos independientes (grupo 1: Formativas; grupo 2: Academia; entre 14-18 años). Se analizan diez indicadores, se incluye la edad. Se demostraron diferencias significativas en el indicador "DB" (p=0.000), el indicador "ÁFRA" (p=0.006), el indicador "DPAE" (p=0.000), y los indicadores "VF", "A" y "TE" (p=0.000) respectivamente, mientras que las variables o indicadores "ÁFRE" (p=1.000), "EX" (p=0.102) y "EY" (p=0.056) no presentaron diferencias significativas entre los grupos independientes. En la comparación realizada con los jugadores de un equipo profesional y los jugadores de una Academia de formación, se pudo evidenciar que existen diferencias notables desde la fase inicial del pase con el borde interno del pie, mostrando la distancia del jugador con respecto al balón, así como en la fase previa donde los jugadores de Formativas poseen una mejor ejecución del movimiento técnico; esto se refleja en la fase de contacto donde se evidencia una mayor velocidad y aceleración al momento del impacto con el balón.

RESUMO A biomecânica é uma ciência que ajuda o estudo dos movimentos aplicados em diferentes desportos, incluindo o futebol, o que permite a identificação e correção de erros técnicos. Esta é uma base fundamental para o controlo da preparação do atleta. Neste sentido, o objectivo da investigação era analisar biomecanicamente o passe com a extremidade interna do pé em jogadores de futebol pré-juvenil e juvenil em treino e academia. A investigação é de tipo descritivo-explicativo, de ordem correlativa; 40 jogadores de futebol são diagnosticados biomecanicamente em dois grupos independentes (Grupo 1: Formação; Grupo 2: Academia; entre 14-18 anos de idade). Foram analisados dez indicadores, incluindo a idade. Foram demonstradas diferenças significativas no indicador "DB" (p=0,000), o indicador "ÁFRA" (p=0,006), o indicador "DPAE" (p=0,000), e os indicadores "VF", "A" e "TE" (p=0,000) respectivamente, enquanto que as variáveis ou indicadores "ÁFRE" (p=1,000), "EX" (p=0,102) e "EY" (p=0,056) não apresentavam diferenças significativas entre os grupos independentes. Na comparação feita com os jogadores de uma equipa profissional e com os jogadores de uma academia de treino, constatou-se que existem diferenças notáveis em relação à fase inicial do passe com a borda interior do pé, mostrando a distância do jogador em relação à bola, bem como na fase anterior em que os jogadores da academia de treino têm uma melhor execução do movimento técnico; isto reflete-se na fase de contato onde é evidente uma maior velocidade e aceleração no momento do impacto com a bola.

ABSTRACT Biomechanics is a science that helps the study of movements applied in different sports, including soccer, which allows identifying and correcting technical errors. This is a fundamental basis for the control of the athlete's preparation. In this sense, the purpose of the research was to analyze biomechanically the pass with the inner edge of the foot in pre-juvenile and youth soccer players of training and academy. The research is of descriptive-explanatory type, of correlational order; 40 soccer players were biomechanically diagnosed in two independent groups (Group 1: Formative; Group 2: Academy; between 14-18 years). Ten indicators are analyzed, including age. Significant differences were demonstrated in the "DB" indicator (p=0.000), the "ÁFRA" indicator (p=0.006), the "DPAE" indicator (p=0.000), and the "VF", "A" and " TE" (p=0.000) respectively, while the variables or indicators "ÁFRE" (p=1.000), "EX" (p=0.102) and "EY" (p=0.056) did not present significant differences between the independent groups. In the comparison made with the players of a professional team and the players of a training academy, it was possible to show that there are notable differences from the initial phase of the pass with the inner edge of the foot, showing the distance of the player with respect to the ball, as well as in the previous phase where the players in formatiom have a better execution of the technical movement; this is reflected in the contact phase where greater speed and acceleration are evident at the moment of impact with the ball.

Two Cases of Abdominal Distension Successfully Treated with Tokishigyakukagoshuyushokyoto / 日本東洋医学雑誌

Abdominal distension is one of the common symptoms and can cause abdominal pain and anorexia, which may raise adverse effect on general well-being and quality of life. In Western medicine, there are specialized treatments for structural lesions associated with abdominal distension, but functional abdominal distension is often difficult to treat. There have been some reports of Kampo medicine for treatment of abdominal distension, but no case reports on tokishigyakukagoshuyushokyoto. We experienced two cases of abdominal distension successfully treated with tokishigyakukagoshuyushokyoto. Case 1 was 86-year-old woman who developed abdominal distension with frequent belching. Case 2 was 59-year-old man who developed abdominal distension associated with opioid. Regulating qi medicine was not effective for abdominal distension in both cases. Both cases had reversal coldness of the extremities, tympanic sounds of abdomen, coldness of abdomen, and inguinal tenderness and resistance. Therefore, we diagnosed them as tokishigyakukagoshuyushokyoto sho. After administration of tokishigyakukagoshuyushokyoto, in Case 1, the frequency of belching decreased and the appetite increased with the improvement of abdominal distension. In Case 2, increasing the dose of goshuyu in tokishigyakukagoshuyushokyoto relieved abdominal distension. Tokishigyakukagoshuyushokyoto can be effective for abdominal distension with interior cold pattern.

Complete Recovery from Generalized Anxiety Disorder Through Anchusan / 日本東洋医学雑誌

We had a female patient who had stagnation of qi and recovered not only by adjusting qi but also by warming interior cold. A 67-year-old woman visited our clinic for generalized anxiety disorder and whole body overstrain on the basis of domestic problems. She had taken anxiolytic, which brought about some relief. She also suffered from uterine cancer, and had operation of uterine resection. After operation, she took radiation therapy, which caused ileus. Although she took daikenchuto, ileus sometimes recurred. At first, we diagnosed her condition as stagnation of liver qi and deficiency of liver blood according to Kampo medical findings, and prescribed yokukansankachimpihange. However, she felt little effectiveness. We focused on her condition as spleen-stomach deficiency cold, and switched to anchusan, which gradually improved her symptom and led to discontinuation of daikenchuto and anxiolytic. She continued to take it for 7 years, and gradually reduced. She stopped taking medication 2 years later, and has had no recurrence ever since. It suggests that anchusan was effective in warming her latent severe interior cold. We should consider anchusan as a therapeutic candidate for stagnation of qi and interior cold, although it is well known Kampo medicine that is suitable for stomach pain.

Environmental interventions to support orientation and social engagement of people with Alzheimer's disease / Intervenções Ambientais Que Dão Suporte À Orientação E Ao Envolvimento Social De Pessoas Com Doença De Alzheimer

ABSTRACT The built environment can be a home to compensatory strategies aimed at increasing the independence of elderly people with Alzheimer's disease, by mitigating the cognitive impairment caused by it. Objective: The aim of this study was to find out which interventions were performed in indoor environments and observe their impacts on the relief of behavioral symptoms related to the disorientation of elderly people with probable Alzheimer's disease. Methods: A systematic review was carried out using the preferred reporting items for systematic review and meta-analyses criteria in the MEDLINE/PubMed database. Two researchers carried out the selection of the studies, following the same methodology. The third author contributed during the writing process and in the decision-making. Results: Of note, 375 studies were identified and 20 studies were included in this systematic review. The identified interventions were classified into environmental communications and environmental characteristics. Conclusions: Environmental communications had positive results in guiding and reducing agitation. In contrast, while reducing behavioral symptoms related to orientation, environmental characteristics showed improvements mainly in social engagement and functional capacity.

RESUMO O ambiente construído pode ser lar para estratégias compensatórias destinadas a aumentar a independência de idosos com doença de Alzheimer, ao mitigar o comprometimento cognitivo causado por ela. Objetivo: Descobrir quais intervenções foram realizadas em ambientes internos e observar seus impactos no alívio de sintomas comportamentais relacionados à desorientação de idosos com provável doença de Alzheimer. Métodos: Uma revisão sistemática foi realizada usando os critérios Preferred Reporting Items for Systematic Reviews and Meta-Analyses na base de dados Medical Literature Analysis and Retrieval System Online/ PubMed. Dois pesquisadores realizaram a seleção dos estudos seguindo a mesma metodologia. O terceiro autor contribuiu durante o processo de redação e nas tomadas de decisão. Resultados: Foram identificados 375 estudos e 20 foram incluídos na presente revisão sistemática. As intervenções observadas foram classificadas em comunicações ambientais e características ambientais. Conclusões: As comunicações ambientais tiveram resultados positivos na orientação e na redução da agitação. As características ambientais, por outro lado, embora reduzam os sintomas comportamentais relacionados à orientação, mostraram melhorias principalmente no engajamento social e na capacidade funcional.

Grado de desajuste entre las características antropométricas y el mobiliario escolar en una muestra de estudiantes españoles de 6 a 12 años: estudio piloto / Degree of mismatch between anthropometric characteristics and school furniture in a sample of Spanish students aged 6-12 years old: A pilot study

Introducción. El mobiliario escolar influye en la postura sedente que adopta el alumnado en el aula, con efectos en su salud y aprendizaje. Por ello, es preciso determinar la existencia de un posible desajuste entre las dimensiones del mobiliario escolar y la antropometría del alumnado, así como realizar una propuesta de tallas en base a la realidad del aula y las normativas de Galicia y la Unión Europea. Población y métodos. Un evaluador experto en antropometría realizó las mediciones de peso, talla, altura poplítea, hombro y codo sentado, con un antropómetro, comparándolas posteriormente con las sillas y mesas utilizadas actualmente. Las técnicas de análisis empleadas fueron: descriptivo (medidas de tendencia central), análisis de la varianza de un factor, prueba t, prueba de chi cuadrado (en software SPSS®) y tamaño del efecto (d de Cohen). El nivel de significación establecido fue de p ≤ 0,05. Resultados. La muestra se compuso de 108 estudiantes españoles de educación primaria (de entre 6 y 12 años). El 91,7 % y el 97,2 % del alumnado emplea, respectivamente, una silla y una mesa que no se ajusta a sus características antropométricas, y utiliza mobiliario con un tamaño superior al que le corresponde. La normativa de tallas de mobiliario que rige actualmente en la población estudiada no es apropiada, al no tener sillas y mesas adecuadas a los primeros cursos de primaria. Conclusiones. Existe un alto grado de desajuste entre el mobiliario y la antropometría del alumnado. Se propone seguir las tallas de la normativa europea, utilizando varias tallas por curso o mobiliario regulable, para adaptarse a las características antropométricas de todo el alumnado.

Introduction. School furniture affects the sitting position of students in the classroom, as well as their health and learning. Therefore, it is necessary to determine the existence of a potential mismatch between school furniture dimensions and students' anthropometric characteristics, as well as to propose dimensions based on classroom actuality and the regulations in place in both Galicia and the European Union. Population and methods. An evaluator with experience in anthropometry measured weight, height, popliteal height, sitting shoulder height, and sitting elbow height using an anthropometer and then compared values with the chairs and desks currently used. Analysis techniques were descriptive (measures of central tendency), single-factor analysis of variance, t test, χ² test (using the SPSS® software), and effect size (Cohen's d test). The significance level was established at p ≤ 0.05.Results. The sample was made up of 108 Spanish children in primary school (aged 6-12 years). Of them, 91.7 % and 97.2 % use, respectively, a chair and a desk that do not adjust to their anthropometric characteristics and use furniture that is larger than what they need. The regulations for furniture dimensions currently in place for the studied population are not adequate because the chairs and desks included are not adequate for the first grades of primary school. Conclusions. There is a high mismatch level between school furniture and students' anthropometric characteristics. We propose the use of the European regulations for furniture dimensions, with varying heights per grade or adjustable furniture that can be adapted to the anthropometric characteristics of all students.

Study on intestinal flora characteristics of asthmatic children based on theory of lung and large intestine being interior-exterior / 国际中医中药杂志

Objective:To explore the characteristics of intestinal flora in children with asthma from the theory of "lung and large intestine being interior-exterior" , and to provide an experimental basis for the study of "lung and intestine axis" .Methods:Based on 16S rDNA high-throughput sequencing technology, stool samples from children with 30 asthma and 28 healthy children were enrolloed and sequenced. All patients are from january 2018 to April 2018, Shanghai Children's Medical Center affiliated to Shanghai Jiaotong University Medical College and Oriental Hospital Affiliated to Tongji University. Statistical methods such as Principal component analysis (PCA), LEfSe analysis, linear discriminant analysis (LDA), and non-metric multidimensional scale analysis (NMDS) were used to analyze intestinal flora characteristics of asthma children.Results:The number of Intestinal flora operating taxon unit (OTU) in asthmatic group (141.96 ± 27.42 vs. 164.54 ± 50.58, P=0.048), Shannon index (2.49 ± 0.51 vs. 2.80 ± 0.56, P=0.044) were significantly lower than those of healthy children group, and Simpson index (0.18 ± 0.06 vs. 0.13 ± 0.07, P=0.010) was significantly higher than that of healthy children. There was no significant difference in intestinal flora abundance between asthmatic children and healthy children ( P>0.05), but there was a decreasing trend. Further differential intestinal flora analysis showed that there were differences in bacterial abundance between children with asthma and healthy children. Conclusion:Children with asthma showed high related with intestinal flora disorders, referring that asthma maybe treated when intestinal flora is treated, which provides a reference for the study of the relationship between lung and intestine from the perspective of intestinal flora.

A Case of Intractable Pruritus of External Auditory Canal Successfully Treated with Tokishigyakukagoshuyushokyoto / 日本東洋医学雑誌

Pruritus of external auditory canal is often treated with blood-enriching formulation and heat-clearing formula. Here, we report a case of intractable pruritus of external auditory canal successfully treated with tokishigyakukagoshuyushokyoto, which did not improve with blood-enriching formulation or heat-clearing formula. Our patient was a 52-year-old woman. She had itching in her left ear from the age of 45, and was treated by 5 otolaryngologists, but her symptom did not improve. I treated her with tokiinshi, shofusan, yokukansankachimpihange, unseiin, jumihaidokuto and keishibukuryogankayokuinin, but they had no effect. After reconsideration of sho, she was diagnosed as interior cold pattern, and she had tenderness in groin area. So I treated her with tokishigyakukagoshuyushokyoto, and her itching disappeared. We should consider interior cold pattern as one of the differential diagnoses of pruritus of external auditory canal.

Two Cases of Hiccups Successfully Treated with Keishininjinto / 日本東洋医学雑誌

Persistent or intractable hiccups worsen the activity of daily life and the quality of life of patients, but are sometimes difficult to treat. There are no recommended therapies in Western medicine for hiccups, and Kampo medicine can often be used. However, there have been no case reports on keishininjinto for hiccups. We experienced two cases of hiccups successfully treated with keishininjinto. Case 1 was a 68-year-old man who continued intractable hiccups for 3 years. Case 2 was an 81-year-old man who developed persistent hiccups during mechanical ventilation. Both cases had spontaneous sweat, tendency of diarrhea, epigastric discomfort and resistance, and cold of epigastrium, so we diagnosed them as keishininjinto-sho. It took 6 months to improve hiccups after administration of keishininjinto in case 1 and 1 week in case 2. Keishininjinto can be effective for hiccups with interior and cold pattern.

El sentido de vida, una condición existencial / The meaning of life, an existential condition

El ser humano siempre ha estado en la constante búsqueda de sentido y preguntándose por su existencia. El hombre moderno además de encontrase en esa búsqueda, también se halla permeado por la angustia constante, está sometido a la cosificación de sí mismo, la hipeconectividad, el consumismo, la incertidumbre y la inmediatez, lo cual lo conduce de manera casi inminente al aburrimiento y el tedio, es decir, a la frustración existencial, llevándolo a enfrentarse con sus pseudosatisfactores y dejándolo de cara ante el vacío de su propia existencia y el cuestionamiento: ¿para qué estoy en el mundo?

Human beings have been in a constant search for meaning and wondering about its existence. The modern man, in addition to finding himself in this search, is also permeated by constant anguish, is subjected to the objectification of himself, hyper-connectivity, consumerism, uncertainty and immediacy, which leads him almost imminently to boredom, which is existential frustration, leading him to face his pseudo-satisfiers and leaving him face to face with the emptiness of his own existence and the question: what am I in the world for?

Ação antimicrobiana do gás ozônio em superfícies e na aeromicrobiota / Acción antimicrobiana del gas ozono en superfi cies y en la microbiota del aire / Antimicrobial action of ozone gas on surfaces and in the air

Resumo Objetivo: Avaliar a ação antimicrobiano do gás ozônio (O3) em superfícies e ar ambiente climatizado artificialmente. Métodos: Estudo experimental/laboratorial e transversal realizado em dez salas de um laboratório de pesquisa em microbiologia médica, com risco de segurança biológica classe 2. As superfícies demarcadas do chão, parede e bancada foram avaliadas, quanto à presença ou ausência de micro-organismos, a partir de coletas feitas com swab umedecido em água destilada estéril, antes e após a exposição do gás O3 gerado por dois equipamentos distintos. Após este procedimento, o swab foi inoculado na superfície do meio de cultura Brain Heart Infusion Agar DIFCO® (BHI), seguindo-se a incubação a 35ºC por 24 horas. Para a análise microbiológica do ar, uma placa com BHI foi exposta aberta por uma hora, antes e após o tratamento do gás O3, sendo incubadas segundo os mesmos critérios. Resultados: A atividade antimicrobiana do gás O3 gerado por ambos os equipamentos foi constatada para todas as áreas investigadas, com registros de redução do número de Unidades Formadoras de Colônias. O potencial de inibição antimicrobiana dos aparelhos se manteve próximo para os critérios de análise adotados, com destaque para as áreas de chão e bancada. Considerando-se todas as salas e percentuais de inibição microbiana, frente aos dois equipamentos, os resultados foram: chão (100%), bancada (90%), parede (50%) e ar, 70%. Conclusão: Os equipamentos geradores de gás O3 apresentaram potencial antimicrobiano para medida de controle de microrganismos presentes em superfícies e ar ambiente climatizado artificialmente, sendo um sanitizante factível para utilização.

Resumen Objetivo: Evaluar la acción antimicrobiana del gas ozono (O3) en superficies y en el aire interior climatizado artificialmente. Métodos: Estudio experimental/de laboratorio y transversal realizado en diez salas de un laboratorio de investigación en microbiología médica, con riesgo de seguridad biológica clase 2. Se evaluaron las superficies delimitadas en el piso, pared y mesa en cuanto a la presencia o ausencia de microorganismos, a partir de muestras recolectadas con hisopo humedecido en agua destilada estéril, antes y después de la exposición del gas O3 generado por dos máquinas distintas. Luego de este procedimiento, el hisopo fue inoculado en la superficie del medio de cultivo Brain Heart Infusion Agar DIFCO® (BHI), y después incubado a 35 °C por 24 horas. Para el análisis microbiológico del aire, se expuso una placa con BHI abierta durante una hora, antes y después del tratamiento del gas O3, y luego se incubó con los mismos criterios. Resultados: Se constató la actividad antimicrobiana del gas O3 generado por ambas máquinas en todas las áreas investigadas, y se registró una reducción del número de unidades formadoras de colonias. El potencial de inhibición antimicrobiana de los dispositivos se mantuvo próximo a los criterios de análisis adoptados, con énfasis en el área del piso y mesa. Considerando todas las salas y porcentajes de inhibición microbiana, con las dos máquinas, los resultados fueron: piso (100 %), mesa (90 %), pared (50 %) y aire (70 %). Conclusión: Las máquinas generadoras de gas O3 presentaron potencial antimicrobiano como medida de control de microorganismos presentes en superficies y aire interior climatizado artificialmente, lo que lo convierte en un desinfectante factible para ser usado.

Abstract Objective: Assess the antimicrobial action of ozone gas (O3) on surfaces and artificially cooled ambient air. Methods: Cross-sectional experimental/laboratory study carried out in ten rooms of a medical microbiology research lab, with class 2 biosafety risk. The demarcated surfaces on the floor, wall and counter were assessed in relation to the presence or absence of microorganisms, based on collections done with swabs dampened in sterile distilled water, before and after exposure to ozone gas produced by two different generators. After this procedure, each swab was inoculated on the surface of a Brain Heart Infusion Agar DIFCO® (BHI) culture, followed by incubation at 35ºC for 24 hours. For the microbiological analysis of the air, a petri dish with BHI was openly exposed for one hour, before and after treatment with O3 gas, and were incubated according to the same criteria. Results: The antimicrobial activity of the O3 gas produced by both generators was checked in all the areas investigated, with records indicating a decrease in the number of colony-forming units. The antimicrobial inhibition potential of the generators was close to the analysis criteria adopted, particularly for the floor and counter areas. Based on all the rooms and microbial inhibition percentages, in relation to the two generators, the results were: floor (100%), counter (90%), wall (50%) and air (70%). Conclusion: The O3 generators had antimicrobial potential as a procedure for controlling microorganisms present on surfaces and in artificially cooled ambient air, constituting a feasible sanitizer.

Genome sizes of four important medicinal species in Kadsura by flow cytometry / 中草药·英文版

Objective: Dianjixueteng is a geoherb in Yunnan Province, the source plant of which is Kadsura interior. However, the formation of this geoherb is not clear in genetic mechanism, in which genome size is the first step that should be known on the genomic level. In this study we aimed to estimate the genome sizes of source plants of K. interior and three related herbs K. heteroclita, K. longipedunculata, and K. coccinea by flow cytometry (FCM) and make a comparison. Methods: The genome sizes of K. interior, K. heteroclita, K. longipedunculata and K. coccinea, i.e., the source plants of Dianjixueteng and its relative medicinal materials, were estimated by FCM. The nuclei of K. interior were isolated using modified LB01 buffer, for the rest species, by the Galbraith's buffer. Results: The genome sizes of K. interior, K. heteroclita, K. longipedunculata, and K. coccinea were 7.36, 7.12, 7.01, and 5.15 pg/1C, respectively. Genome size of K. interior had no significant variation with those of K. heteroclita and K. longipedunculata (P = 0.296), which was significantly larger than that of K. coccinea. Conclusion: Genome size can not distinguish K. interior from K. heteroclita and K. longipedunculata, but could distinguish them from K. coccinea, which lays the foundation for future studies on genetic mechanism of the geoherb formation.

Syndrome Differentiation-based Treatment of COVID-19 Based on Theory of Wenyilun / 中国实验方剂学杂志

The outbreak of corona virus disease-2019 (COVID-19) in Wuhan, China, in December 2019, is highly contagious and epidemic, and belongs to the category of "plague" in traditional Chinese medicine, which seriously threatens human life and health. In the face of this sudden public health event, based on the theory of Wenyilun, this paper analyzes the onset characteristics, transmission, and syndrome differentiation-based treatment of COVID-19 in clinical practice. According to the characteristics of this epidemic, the pathogeny of COVID-19 is "epidemic pathogenic factors", and the pathogenesis is that the epidemic suppresses the dampness. Its transmission follows the regularity of "nine transmissions between exterior and interior" recorded in Wenyilun, which can be divided into sequential transmission and reverse transmission. The course of the disease has certain regularity and stages. In the early stage, the pathogen hides in the pleurodiaphragmatic interspace, and the epidemic suppresses the dampness， the treatment shall reach the pleurodiaphragmatic interspace, clear the dampness and turbidness, diffuse the lungs and dredging the lung meridian. In the middle stage, the pathogen can be transmitted to the exterior， the treatment shall be pungent in flavor and cool in property and could relieve the exterior syndrome, so as to remove the pathogen by shivering and sweating. If the dampness toxin enters the interior and be transmitted into the heat, and caused damage to the lung meridian, obstruction of Qi in the lungs, interior excess and heat accumulation, the treatment shall dredge bowel and purge heat, and expel the pathogen out. Any delay in treatment, mistreatment or excessive pathogen can lead to pathogenic invasion into the pericardium, and cause delirium, dysphoria, reversal cold of limbs, barely palpable pulse and other critical manifestations of internal blocking causing external depletion. The treatment shall focus on both attack and supplement, open blocking and relieve depletion. In the recovery period, due to the residual pathogen and the Yin and Qi impairment caused by fever, the treatment shall prevent the recurrence of the residual pathogen, nourish Yin and blood, and restore the vital energy. During the treatment, WU You-ke put forward three principles of "removing the pathogen as the priority, and then avoiding false sweating, and caring for the spleen and stomach". The theory of Wenyilun has a systematic understanding of the pathogeny, pathogenesis, and syndrome differentiation-based treatment of "the epidemic", and provides valuable experience for fight against plagues in later generations, which is also of great significance for the prevention and treatment of COVID-19.

Brief analysis of the relationship between " of foot- stomach-meridian syndrome and stomach / 中国针灸

"" is a word describing the syndrome of cold sensation, which is one of the foot- stomach-meridian syndromes. The lesions of stomach and meridian could cause changes of and superficial symptoms of the interior syndrome, leading to "". In this study, the specific manifestation of the "" is analyzed from the aspect of word meaning, and the relationship between the "" and stomach is further discussed through the perspectives of and the exterior-interior relationship. In addition, combined with typical clinical case, it is suggested that attention should be paid on the relationship between exterior and interior syndromes, and the clinical application of and method (activating and promoting circulation of organs) should be strengthened, which could expand the new thinking of clinical treatments for viscera diseases through acupuncture and moxibustion.

Determinants Of Patient Satisfaction On Interior Design Quality Of Public Hospitals In Malaysia

@#Being in a hospital can be a stressful experience especially to the patients. The importance of design quality as a trigger to patients' satisfaction is becoming a topic of significant relevance as it also impacts the building operation. This study aims to determine the factors influencing the patients' satisfaction toward the interior design quality of inpatient units at public hospitals in Malaysia. Self-administered questionnaires were distributed among 483 inpatients from 5 Obstetrics and Gynaecology wards at public hospitals in the Klang Valley region. The Structural Equation Model (SEM) technique was applied to examine the causal relationship and to test the hypothesis of the patients' satisfaction toward the interior design quality. The results revealed that space planning (β = 0.265), lighting (β = 0.263), furniture (β = 0.243), and color (β = 0.138) have a significantly positive effect on patients' satisfaction toward the interior design quality. Whereas way-finding, safety, air quality and accessibility have no significant effect on the patients' satisfaction. This study concludes that certain qualities of interior design have great impact on patients' satisfaction. The findings proved that revamping the inpatient units' space planning can lead to significant patient experience improvements, while the aspect of accessibility is the least concern to the patients when they stay in the hospital. This study provides input to help designers, architects and hospital planners to evaluate their priorities in planning and designing better hospitals in the future.

The Influence Of Children’s Playroom Interior Aspect In Regard To Parental Safety Perception. Case Study: Children’s Playroom At 23 Paskal Bandung, Indonesia

@#Children’s playrooms in public spaces need to consider the safety of their interior elements. Previous studies also discussed about things that need to be taken into account to assure the children’s safety while playing. However, some parents join their children playing in public spaces due to the cautiousness of playground safety level. This study was conducted to understand how far the interior aspects of children’s playgrounds can affect parents’ safety perception to let their children play by themselves in public spaces, for example, the children’s playroom in 23 Paskal Bandung, West Java, Indonesia. The result shows that sufficient light, interior finishes, and noise or sound intensity in the children’s playground at 23 Paskal Bandung, Indonesia can make parents feel safe to let their children spend time there.

Preliminary observation on imbalance degree of impedance in extracellular fluid of cells in the twelve meridians in healthy subjects / 中国针灸

OBJECTIVE@#To calculate the imbalance degree (IBD) of left-right meridian (IBD-LRM), IBD of exterior-interior meridian (IBD-EIM) and IBD of hand-foot meridians (IBD-HFM) of impedance in extracellular fluid of cells in twelve meridians of healthy subjects, so as to provide foundation for meridian diagnosis.@*METHODS@#A total of 31 healthy volunteers were enrolled and bioelectrical impedance spectroscopy (BIS) was applied. The constant current (from 1 to 100 kHz, 200 μA) was connected into the bilateral twelve meridians through two excitation electrodes with a distance of 10 cm. Two measuring electrodes, with an interval of 5 cm, were set in between the two excitation electrodes to collect the voltage amplitude and phase. The Cole-Cole curve fitting was used to calculate the impedance of extracellular fluid of cells in the twelve meridians; the IBD-LRM, IBD-EIM and IBD-HFM as well as their absolute values were calculated.@*RESULTS@#The impedance of extracellular fluid in the left side was higher than that in right side in the large intestine meridian, the small intestine meridian and the bladder meridian (<0.05, <0.01). The mean value of IBD-LRM of extracellular fluid was (4.0±1.4) %; the mean value of absolute value of IBD-LRM was (15.0±1.1) %; the maximum absolute value of IBD-LRM was the bladder meridian. The mean value of IBD-EIM was (3.3±1.0) %; the mean value of absolute value of IBD-EIM was (17.9±1.6) %; the maximum absolute value of IBD-EIM was the bladder meridian and the kidney meridian. The impedance of extracellular fluid of hand meridian, hand meridian and hand meridian were lower than those of foot meridians. The mean value of IBD-HFM was (-2.6±1.1) %; the mean value of absolute value of IBD-HFM was (19.7±1.7) %; the maximum absolute value of IBD-HFM was meridian; the imbalance of meridians was greater than meridians. There were significant differences in impedance of extracellular fluid between left and right and between hands and feet (<0.05, <0.01).@*CONCLUSION@#The extracellular fluid of left-right meridians of healthy subjects is different, but the absolute value of IBD is low; the mean value of exterior meridian and interior meridian is very close, and the absolute value of IBD is medium; the impedance of the foot meridians are greater than the hand meridians, and the absolute value of IBD is relatively high.