RÉSUMÉ
Objective: To observe the therapeutic effect of video-assisted thoracoscopic surgery (VATS) with iodine tincture pleurodesis on malignant pleural effusion (MPE). Methods:Clinical data from 47 MPE cases were retrospectively analyzed. Based on different treatments, the 47 cases were divided into Groups A (n. 25) and B (n. 22), which used iodine tincture and talc powder as a hard-ener, respectively. Provided that all cases were conclusively diagnosed as MPE, and the patients underwent VATS pleural biopsy and pleurodesis, Groups A and B were comparable. The authors then compared the postoperative effectiveness rates (both complete and par-tial remissions), the volume of chest drainage, the incidence of adverse reactions, and the drainage time of the chest tube between the two groups. Results:Difficulty in breathing was proven to be less severe among all cases after the operation, and none of the patients suffered from acute lung injuries. After the operation, Group A exhibited an effectiveness rate of 96.0%, whereas Group B presented a rate of 95.5%, which indicates that no significant difference was found between the two groups (P>0.05). The total incidence of adverse reactions was 32.0%in Group A and 63.6%in Group B, with a significant difference between the two (P<0.05). Conclusion:VATS io-dine tincture pleurodesis has been proven to be as therapeutically effectual as talc pleurodesis and has resulted in fewer adverse reac-tions. This finding suggests that VATS iodine tincture pleurodesis has a promising potential in clinical practice because of its definite cu-rative effect, simple management, high security, fewer adverse reactions, and reasonable cost.
RÉSUMÉ
Objective To investigate whether ultrasonic coupling agent (UCA)can produce shielding or antago-nistic effect on iodine disinfectant for preoperative skin disinfection.Methods Shielding or antagonistic effect of UCA on iodine disinfectant were detected by laboratory carrier immersion killing test and on-the-spot skin disinfec-tion test.Results Antagonistic effect:after the mixing of iodophor with UCA,the average killing rate of iodophor containing available iodine 2 500mg/L and 625 mg/L to Staphylococcus aureus decreased from 100.00% to 99.67%-99.78% and 96.85 % - 98.25 %,respectively;the average killing rate to Escherichia coli decreased from 100.00% to 99.71 %-99.82% and 95 .93 %-98.56%,respectively.Shielding effect:after smearing with UCA, the average killing rate of iodophor and iodine tincture + alcohol to Escherichia coli decreased from 100.00% to 30.76% and 100.00% to 94.48%,respectively;the average killing rate to Staphylococcus aureus decreased from 99.99% to 55 .55 % and 100.00% to 98.22%,respectively.On-the-spot skin disinfection test:the killing rate of io-dophor and iodine tincture +alcohol to natural bacteria on skin surface were both 99.99%,after skin was smeared with UCA,the killing rate decreased to 92.62% and 93 .57%,respectively.Conclusion UCA remained on the oper-ative field has shielding and antagonistic effect on iodine disinfectant.
RÉSUMÉ
A aplicação do controle estatístico para monitorar o desempenho da etapa de envase de formas farmacêuticas líquidas consiste em obter informações e estabelecer estratégias para a validação do processo, assim como possibilitar o gerenciamento deste a partir da percepção do comportamento das variáveis críticas do produto durante a produção. Esta etapa do processo possui como variável crítica o volume de envase. Variações neste parâmetro fora dos limites de qualidade pré-estabelecidos pela legislação refletem ineficiências durante o processo podendo ocasionar a reprovação do produto. Para demonstrar de forma objetiva o grau de segurança requerida para este tipo de processo foram utilizadas ferramentas do controle estatístico de processo (CEP) para estudar e validar o desempenho da etapa de envase da tintura de iodo fabricada pela indústria farmacêutica Lapon Química e Natural Ltda. (Limoeiro - PE, Brasil), bem como verificar a estabilidade estatística e capacidade do processo. As atividades de melhoria, através da identificação e eliminação das causas especiais de variação do processo, permitiram a redução de sua variabilidade, assegurando uma melhoria contínua da qualidade nos resultados da produção.
Statistical control is used to monitor the performance of the fill phase in the manufacture of liquid pharmaceutical forms, to obtain information and establish criteria for process validation, as well as to enable control of the process, by observing the behavior of the critical variables during production. The critical variable at this stage of the process is the filling volume. Variations in this parameter outside the established legal quality limits reflect inefficiency in the process that may result in product rejection. To demonstrate objectively the degree of security required in this type of process, statistical process control (SPC) tools were used to study and validate the performance of the fill phase in production of iodine tincture by the Pharmaceutical manufacturer Lapon Química e Natural Ltda. (Limoeiro - PE, Brazil), as well as to check the statistical stability and capacity of the process. Optimization of the process, by identifying and removing the specific causes of variation, led to a reduction in its variability, ensuring a continual improvement in the quality of production.
Sujet(s)
Humains , Emballage de médicament , IodeRÉSUMÉ
OBJECTIVE To observe the effect of Anerdian on operation field disinfection instead of iodine tincture.METHODS Totally 40 354 surgical patients used Anerdian during from Jan 2005 to May 2007 were studied in comparison with 15 840 cases used iodine tincture during 2004.RESULTS There was no significant difference in disinfection effect between Anerdian and iodine tincture.CONCLUSIONS Anerdian is an effective,convenient and available disinfectant for operation field disinfection.
RÉSUMÉ
OBJECTIVE To observe the clinical efficacy of two kinds of compound skin disinfectants(compound iodine and Anerdian).METHODS One hundred and twenty recruited patients were divided into three groups randomly,group A(compound iodine group),group B(Anerdian group) and control group(iodine tincture group),40 patients per group.The groups A and B were carried on with one-step skin greasing disinfection.The control group was carried on with routine two-steps skin greasing disinfection.The sampling and detection were carried on by The Technological Specification of Hospital Disinfection published by the Ministry of Health.RESULTS The kill ratio of three groups was(95.44?9.45)%,(95.29?7.21)% and(96.24?11.12)%,respectively.Their disinfection qualification ratio was 97.50%,95.00% and 97.50%,respectively.Comparing the kill ratio and disinfection qualification ratio,there was no significant difference among three groups.CONCLUSIONS The disinfection efficacy of two kinds of the compound skin disinfectants are definite,there is no difference comparing with the traditional iodine tincture and ethanol disinfectants,but they are easy to carry on,safe and practical and the time is shorter,saving the time and the labor.It is helpful to increase the work efficiency of the nurse and deserve to be extended in the clinical application.