Résumé
Background@#<i>Iris Tenuifolia</i> and <i>Iris Lactea</i> known for its various medicinal properties are also a natural antichloristic and a kidney protective as agent.@*Goal@#To evaluate the nephrite activity of aqueous extract of <i>Iris Tenuifolia</i> and <i>Iris Lactea</i> in a rodent model of kanamycin induced nephrotoxicity. @*Materials and Methods@#In the experimental design, thirty-six Wistar rats were randomly isolated into four groups of one control and three experimental. Nephrotoxicity in rats induced by intramuscular injection of Kanamycin {250 mg/kg) daily for 5 days<sup>5</sup>. The doses of 25 mg/kg, 50 mg/kg, 75 mg/kg, 100 mg/kg of aqueous extract of <i>Iris Lactea</i> and dose of 25 mg/kg <i>Iris Tenuifolia Pall</i> were administrated by oral gavages for 14 consecutive days in rats. At 14 days for the rest of them, serum samples were collected for renal function biochemical tests (Creatinine, Creatinine Clearance, Urea UV and GFR-Glomerulus Filtration Rate). @*Results@#All statistical analyses were conducted with SPSS version 20.0 software (IBM, Armork. NY). One-way ANOVA was used to assess statistical significance between experimental groups and control group. Mean values of creatinine, creatinine clearance, urea UV and GFR levels determined in the control and experimental groups. Kanamycin treatment caused nephrotoxicity as evidenced by marked elevation in serum creatinine, creatinine clearance, GFR and urea UV, <i>Iris Tenuifolia</i> 25 mg/kg blood serum creatinine (62.49±1.24 (38%), 56.38±1.41 (4.5% μmol/L), serum creatinine clearance (4.79±0.16 (45%), (5.80±0.36 (6%) ml/minute), serum GFR (191.6±6.58 (45%). (232±14.65 (5.9%) ml/minute), serum urea UV (8.64±0.63 (9.6%), (8.40±0.07 (20.23%), Iris Lactea 75 mg/kg blood serum creatinine 68.92±4.08(31%), 58.87±1.95 (0.4% μmol/L), serum creatinine clearance (5.27±0.67(60%), (5.67±0.28(3.6%) ml/minute), serum GFR (210.9±26.78 (60%), (226.8±11.28 (3.5%) ml/minute), serum urea UV (7.73±0.58 (19.14%), (7.48±0.35 (28.96%) respectively when compared to the control treated groups. Oral administration of <i>Iris Lactea</i> 75 mg/kg extract decreased the rise in these parameters in a dose dependent manner. @*Conclusion@#Our studies suggest that aqueous extract of <i>Iris Lactea</i> 75 mg/kg and <i>Iris tenuifolia</i> 25 mg/kg results are shown good effect for anti-inflammatory of renal.