Résumé
Anthocephalus indicus or A. indicus (family Rubiaceae; Hindi name KADAMBA or KADAM) is one of such ayurvedic remedy that has been mentioned in many Indian medicinal literatures. This article discusses about the medicinal principles of Anthocephalus indicus. In this communication, we reviewed the phytochemistry of Anthocephalus cadamba and its application in the cure of various ailments like diabetes mellitus, diarrhoea, fever, inflammation, haemoptysis, cough, vomiting, wounds, ulcers, debility and antimicrobial activity. The major constituents of the plant are triterpenes, triterpenoid glycosides, flavanoids, saponins, indole alkaloids; cadambine, cadamine, isocadambine, isodihydrocadambine. This review discusses the investigations made by various workers related to chemical constituents, pharmacological action and toxicological studies of this plant since years till date.
Résumé
OBJECTIVE:To investigate the regulation effects of policosanol on lowering cholesterol and its enzymatic mechanism.METHODS:The rats were randomly assigned into control group,policosanol prevention group (4.0 mg?kg-1?d-1),policosanol low-dose,medium-dose and high-dose groups (4.0 mg?kg-1?d-1,6.0 mg?kg-1?d-1,8.0 mg?kg-1?d-1),lovastatin group (positive control) and hyperlipoidemia model group.The last five groups were induced hyperlipoidemia model for 4 weeks.Blood samples were collected after 6 weeks administration (i.g.).The levels of TC,TG,LDL-C and HDL-C in the serum were determined.Body weight and liver weight were measured and hepatic index was calculated.The activity of lecithin cholesterol acyl transferase (LCAT) in serum,hepatic lipoprotein lipase (LPL) and hepatic lipase (HL) were detected.RESULTS:Policosanol remarkably decreased the levels of TC (ranged from 39.1% to 43.3%) and LDL-C (ranged from 66.6% to 80.7%) in serum and hepatic index (ranged from 11.1% to 11.8%) (P