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1.
Rev. méd. Chile ; 150(3): 397-401, mar. 2022. ilus, tab
Article Dans Espagnol | LILACS | ID: biblio-1409816

Résumé

BCR-ABL1 negative atypical chronic myeloid leukemia (aCML) is a rare type of myeloproliferative / myelodysplastic syndrome characterized by leukocytosis and proliferation of dysplastic neutrophilic precursors in the absence of positivity for the BCR-ABL1 fusion gene. We report a 66-year-old woman and a 57-year-old man with aCML, who initially presented with general malaise and weight loss, associated with anemia, thrombocytopenia, and leukocytosis with left shift and dysplasia in the neutrophil series. Both evolved unfavorably after admission and died a few days later due to multiple organ failure.


Sujets)
Humains , Mâle , Femelle , Adulte d'âge moyen , Sujet âgé , Thrombopénie , Leucémie myéloïde chronique BCR-ABL positive/diagnostic , Leucémie myéloïde chronique BCR-ABL positive/génétique , Leucémie myéloïde chronique atypique BCR-ABL négative/génétique , Hyperleucocytose
2.
Rev. bras. hematol. hemoter ; 35(3): 218-219, jun. 2013. tab, graf
Article Dans Anglais | LILACS | ID: lil-681980

Résumé

We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemia with a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance to the tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, the patient showed no hematologic response and was submitted to an allogeneic bonemarrow transplantation. Fifty-three days after the procedure, he died due to acute graft-versus-host disease. This BCR-JAK2 fusion gene has so far been found in only five patients in the whole world, with three clinical presentations: myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloid leukemia.


Sujets)
Humains , Mâle , Adulte d'âge moyen , Leucémie myéloïde , Protéines proto-oncogènes c-bcr , Leucémie myéloïde chronique atypique BCR-ABL négative , Maladies myélodysplasiques-myéloprolifératives
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