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1.
Article | IMSEAR | ID: sea-227144

RÉSUMÉ

Background: According to the recent studies on patients with stones in the urinary system, the CRP serum levels can be useful in predicting the possibility of success in expectant treatment and spontaneous excretion of stone and thus, selecting the appropriate patient for this treatment approach; however the studies conducted in this field are inadequate and the results obtained are slightly contradictory. The aim of this study was to investigate the relationship between spontaneous excretion of lower ureter stones with stone size and serum level of C-reactive protein. Methods: This cross-sectional study has been done on 95 patients with lower ureter stone during 2020-2021. Information including gender, age, body mass index, stone size, spontaneous excretion of stone, and CRP serum level were extracted from the files of patients. The existence of stone and its characteristics have been confirmed using ultrasound. Results: The mean CRP serum level was 8.74�5.06 mg/l and the frequency of spontaneous stone excretion was 72.6% (n=69). CRP serum level was significantly lower in patients with spontaneous stone excretion (7.42 vs. 12.23 mg/l and p=0.001). The cut-off point of CRP serum level was 13.5 mg/l for patients with ureter stone size of 4-7 (with 84% sensitivity and 58% specificity) and for patients with ureter stone size of 7-10, it was 12.5 mg/l (with 83% sensitivity and 56% specificity). Conclusions: The results showed that there is a significant relationship between the CRP serum levels, along with stone size with spontaneous excretion of lower ureter stones.

2.
Article | IMSEAR | ID: sea-213250

RÉSUMÉ

Background: The lifetime risk of kidney stones is between 5% and 10% and rates of recurrence are as high as 50%. Majority of the ureteric stones (70%) are found in the lower third of the ureter. Available setup, type, size of the stone, and expertise of the surgeon are the major factors affecting the treatment modality. Medical expulsive therapy has shown promising results in previous studies. Aim of the study was to assess the efficacy of tamsulosin and deflazacort combination therapy for stone expulsion in relation with site and size of stones.Methods: A total of 97 patients with ureteric calculi of size 10 mm or less attending the urology out-patient department were included. Received medical expulsive therapy using tamsulosin (0.4 mg) and deflazacort (30 mg) for 7 days. Patients were evaluated for stone expulsion on 7th day by non-contrast computed tomography of kidney ureter bladder. Site, side and size of stones were noted.Results: Ureteric calculi was more prevalent in the age group of 21-30 years 38 (39.2%). Male preponderance was observed (76.28%) with male female ratio being 3.2:1. Lower site 64 (65.97%) ureteric calculi were most common. The majority had a stone size of 4-6 mm (42%). Stones were expelled on 7th day in 69 (71.13%) patients. Expulsion rates were highest for the stone size of 2-4 mm (94.4%) followed by 4-6 mm (88.1%). The highest expulsion rates were observed for Lower ureteric stones (84.4%).Conclusions: Medical expulsive therapy using tamsulosin and deflazacort is an effective treatment modality for the management of ureteric stones, especially those present in lower ureter and those ≤8 mm in size.

3.
China Pharmacy ; (12): 2915-2917, 2016.
Article de Chinois | WPRIM | ID: wpr-504701

RÉSUMÉ

OBJECTIVE:To compare the efficacy and safety of tamsulosin or nifedipine or racanisodamine in the treatment of lower ureteral calculi. METHODS:160 patients with lower ureteral calculi were randomly divided into group A(40 cases),group B(40 cases),group C(40 cases)and group D(40 cases). All patients drank plenty of water to make daily urine output more than 2 000 ml. Based on it,group A orally received 0.4 mg Tamsulosin hydrochloride sustained release capsule,once a day. Group B orally received 10 mg Nifedipine tablet,3 times a day. Group C orally received 10 mg racanisodamine tablet,3 times a day. Group D received no other drugs except for increasing drinking. The treatment course for all groups was 2 weeks. Clinical efficacy,litha-gogue time,lithagogue size,residual calculi size and the incidence of adverse reactions in all groups were observed. RESULTS:The total effective rate in group A was higher than group C,which was higher than group B and group D,the differences were sta-tistically significant(P0.05). Lithagogue size in group A was more than group C,which was more than group B and group D,the differences were statistically significant(P0.05). Residual cal-culi size in group A was less than group B,which was less than group C and group D,the differences were statistically significant (P<0.05). And there were no severe adverse reactions in all groups. CONCLUSIONS:The efficacy of tamsulosin is superior to nifedipine and racanisodamine in the treatment of lower ureteral calculi,while nifedipine and racanisodamine show similar effica-cy,with better safety.

4.
Article de Chinois | WPRIM | ID: wpr-580158

RÉSUMÉ

Objective:To observe and assess the effect of Tamsulosin in the treatment for lower ureteral calculi. Methods: 378 patients with ureterolithiasis in the lower ureter were randomly divided into two groups: The contral group(n=162) was subjected to the regular treatment(Dang Shipian 1.8g Tid for 4 weeks and with drinking water over 2 000 ml per day); The treatment group(n=216) was regular treatment combined with Tamsulosin (0.2 mg Bid for 4 weeks). Results: In treatment group, 86.1% (186 of 216) of the patients expelled the calculi and was higher than 38.3%(62/162) in contral group. The mean time discharged calculis in treatment group was more shorter than the contral group. Conclusion: The treatment of Tamsulosin could accelerate calculi discharge from lower ureter and increase the discharge rate of calculi.

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