Résumé
[Objective] To observe the anti - aging effects and explore the mechanism of Qibao Meiran Pellet (QMP) and its modified prescriptions, including QMP with qi - invigorating and spleen - strengthening herbs, with kidney -nourishing herbs or with blood - activating and purgative herbs. [ Methods ] Ten - month - old model rats were established by D - galactose. Serum free radical levels and immune indexes in QMP group and various modified QMP groups were observed. [ Results ] QMP increased the activity of superoxide dismutase ( SOD). QMP combined with kidney - nourishing herbs or blood - activating and purgative herbs decreased the serum level of malondialdehyde (MDA) and increased the activities of glutathione peroxidase (GSH - Px) and SOD. Meanwhile, QMP combined with kidney -nourishing herbs increased interleukin - 2 activities. [ ConclusionJ QMP, mainly composed of herbs for nourishing liver and spleen, can delay the aging of rats, and spleen - strengthening herbs and blood - activating and purgative herbs also play an important role in the delay of aging. Furthermore, it is suggested that the anti - aging effect of herbal medicine is related to the sex.
Résumé
[Objective] To investigate the effect of sporoderm-broken spores of Ganoderma Lucidum in the treatment of partial androgen deficiency of the aging male (PADAM) . [Methods] Random number table was used for the division of 138 PADAM cases. Sporoderm-broken Ganoderma Lucidum spores capsules were given orally to group A (n=80) and placebo to group B (n=58). The treatment course lasted 3 weeks. Self-scoring of physical ability, vasomotoricity, mental psychological state and sexual function was used to evaluate the therapeutic effect. Meanwhile, blood contents of testosterone (T), erythrocyte superoxide dismutase (SOD) and malondialdehyde (MDA) were determined and adverse reaction was observed. [Results] After a 3-week treatment, the scores of physical ability, vasomotoricity, mental psychological state and sexual function were decreased in group A (P 0.05) and the difference was significant between the two groups (P