Protective effects of ginkgolide k on focal cerebral ischemia reperfusion injury in rats on the basis of amelioration of mitochondrial calcium uniporter / 中国药学杂志

OBJECTIVE: To explore whether the protective mechanism of ginkgolide K on cerebral focal ischemia reperfusion injury in rats induced by middle cerebral artery occlusion (MCAO) was associated with the amelioration of mitochondrial calcium uniporter ( MCU) or not. METHODS: Sprague Dawley (SD) rats were divided into 5 big groups randomly: sham operation group, MCAO group, GK added into RR group, GK group and GK added into SM group. The MCAO rat model were established after cerebral artery ischemia for 2 h and reperfusion for 22 h. Zea Longa 5 score system was used to evaluate neurological deficit score; Determination of brain water content and cerebral infarction areas were determined using gravimetric method and by triphenyltetrazolium chloride(TTC) staining method, respectively. In addition, malondialdehyde (MDA) and superoxide dismutase (SOD), nitric oxide synthase (NOS), nitric oxide (NO) were detected by Elisa. Additionally, mitochondrial[Ca2+] i concentration was estimated with the fluorescence spectrophotomete. The morphological change of the injured brains were observed by HE staining. The expression of caspase-3/8/9 protein were detected by Western blot. RESULTS: Compared with GK group, GK + RR group relieved obviously the neurological deficit score and reduced the cerebral infarction areas, brain water content, mitochondrial[Ca2+]i concentration and MDA, caspase-3/8/9 protein expression while enhance SOD activity. However, the effect of SM on the GK protective activity in MCAO rat injury was the opposite in comparison to GK + RR group. CONCLUSION: The stimulative effect of RR and the inhibitory effect of SM on the GK protection in MCAO rat had proves that the protective mechanism of GK on MCAO rat injury is associate with its down-regulation of the transport capacity of MCU, leading the attenuation of mitochondrial[Ca2+]i influx.

System Integration of Infant Incubators' Quality Control Testing Based on MCU / 中国医疗器械杂志

This study is aimed to design the testing system of multiple parameters of the incubators, and to make their quality control plans. Also it is required to establish a model of data collection and processing based on MCU, and to program the host computer software in order to analyze data. The result shows that the testing system is accurate and stable; also it is convenient to collect the data. This testing system is a good complement of the quality control of incubators. It has a high practical value in improving medical safety and reducing the occurrence of adverse events.

The Pulse Monitoring System Based on MCU and GSM / 中国医学物理学杂志

Objective: This thesis describes a pulse monitoring system based on MCU and GSM. Methods: Monitoring system is a wireless remote monitoring devices which using the SMS in GSM mobile communications network. The signal of pulse is acquisited by Acquisition Circuit, after timing and counting by MCU, pulse rate above the standard is directly transmited to family cell or Dr Mobile by GSM. Results: If the patient arises suddenly heart disease, monitor can be promptly sent to the pulse rate above the standard for family cell or Dr Mobile so that patients receive timely aid. Monitor has advantages of a wide coverage, economic and convenience. Conclusions: The monitor will greatly reduce the burden on the patient's family and hospital, This pulse monitoring system can meet with demands of service in the family and villa nursing and hospital.

USB Data Collection System Based on MCU C8051F340 / 医疗卫生装备

The characteristics of C8051F340 MCU and USB communication, and the design method of system's hardware and software structure are introduced briefly. The whole system is proved stable and reliable by experiment. The Universal Serial Bus (USB) communication technology has great value in course of system design and study.

Design of USB Bus power circuits for neuromuscular rehabilitator / 医疗卫生装备

This paper analyses the characteristics of USB bus power.Based on the power demand of the circuits for neuromuscular rehabilitator,power voltage transformation circuits are designed for the realization of USB bus power supply.

Development of an Environmental Temperature Supervising Network System / 医疗卫生装备

This paper introduces the principles of an Environmental Temperature Supervising Network System, explain its hardware and software structure and the function of network system. The whole system is proved stable and reliable by experiment. It may have some profit in the market and great future in the application.

Working Principle of Frence-made C-arm / 医疗卫生装备

In order to raise the work efficiency in service and maintenance,the structure and working principle of the machine are analyzed on the basis of apprehending the main device MCU.Combining with the troubleshooting practice,it is stressed that the knowledge of hardware and software is meaningful to those medical electronic engineering personnel.

Detection system of multi-channel physiological parameters of uterine cavity based on USB interface / 医疗卫生装备

USB interface chip PDIUSBD12 and Microchip's single chip processor PIC16F877 are applied to achieving computerized multi-channel data acquisition, and then a detection system of multi-channel physiological parameters of uterine cavity is designed on the basis of the above-mentioned. Being plug-and-play, real-time and general-purpose, this system can meet the requirement of medical research on the relationship between these parameters and diseases of uterine cavity.

Development of multi-function hydraulic pressure diagnostic and therapeutic instrument / 医疗卫生装备

This paper introduces some information of the multi-function hydraulic pressure diagnostic and therapeutic instrument, which is applied to the diagnoses and treatments of oviduct, matrix, urethra, bladder and bile duct, including its system function, operation principle, software and hardware designs. Being reliable, cheap, convenient and multipurpose, the instrument has a bright future in the market.

Design of centralized infusion managing and controlling system / 医疗卫生装备

This paper describes the structure, operating principles, design method of both software and hardware of a centralized controlling system of infusion pumps based on CAN bus. The system can monitor the status information and control the infusion parameters of many infusion pumps simultaneously. It provides a more complicated cliaical infusion treatment means, greatly eases the work burden on doctors and nurses, and promotes the effects of treatment and nursing.

Study on Brainwave Music Software of Brainwave Therapeutic Apparatus / 医疗卫生装备

Objective To put forward a design of the software of brainwave therapeutic apparatus based on the MCU. Methods Based on principle of electroencephalogram music treatment, several sound synthesis techniques were analyzed and contrasted. A simple and easily-realized one was selected and analyzed in detail. Finally, the output of brainwave therapeutic apparatus was tested and errors were analyzed. Results The selected scheme can effectively generate brainwave music. Conclusion According to the scheme, a low-cost and reliable brainwave therapeutic apparatus can be made by using the MCU.

Study and design of portable medical drop speed monitoring equipment / 医疗卫生装备

Objective To develop a portable medical drop speed monitoring equipment which can conveniently control the drop speed in infusion.Methods Taking the monolithic integrated circuit of 89C51 as a core,such units were designed as the master control unit,keyboard input system,drop speed detection,drop speed control,digital display,acousto-optics alarm circuit and electromotor drive.All circuit module units were connected in monolithic integrated circuit.The gathering data were transferred to monolithic integrated circuit in the form of electrical signals.After the operation,analysis and processing,monolithic integrated circuit transferred the data to demonstration module,electrical machinery and acousto-optics alarm circuit through the outlet.Results Automatically controlling the drop speed according to the difference of drop speed,this equipment can reach the required drop speed in 5~10s and maintain this speed with an error of 12 drops per minutes.Conclusion Portable medical drop speed monitoring equipment achieves the goal of the task and meets the clinical requirement.This equipment is worthy of popularizing.

Design of Electric Stimulator of Cell Culture / 医疗卫生装备

Objective To design an instrument that can provide a series of pulse to stimulate cell by means of external electric field, the structure and function of organism can retrieve. Methods AVR MCU, produced by America ATMEL Co., is used as the core of the system. The program has been developed to adjust three pulse's parameters, including amplitude, frequency and pulse duration. The cooperation between DAC and OP completes the transformation from monopole pulse to bipolar pulse. The booster PB50 amplifies the current and voltage of the output. Results The Stimulator can provide bipolar pulse, amplitude: up to ?40V, frequency: 0.01Hz -10Hz, pulse duration: 0.4ms -24ms. Conclusion Cooperating with special electrode board, the instrument can provide effective electric field for cell simulating. At present the instrument has been used in the research of the endothelial progenitor cell.

Design of the midget ultralow power consumption ECG auscultoscope / 医疗卫生装备

As a substitute of the traditional auscultoscope, the midget ultrolow power consumption ECG auscultoscope combines the traditional one with the electrocardiograph, which is easy to operate and carry.

Research on Multilevel Distributed System Based on W77E58 for Community Health Monitoring / 医疗卫生装备

Objective To design a new multilevel distributed community-oriented health monitoring based on two serial ports MCU of W77E58.Methods Multi-machine serial communication with high-performance and full-duplex was realized by using the standard RS422 serial interface,which involved several parts in,such as detection and processing module of physiological parameters,communication module and display processing module of the host computer.With the different functional modules and software and hardware connection,multilevel distributed health monitoring was realized.Results RS422,being a simple,easy to control and low-cost communication mode,implemented the communication between these modules.Finally,the distributed measurement & control system with one PC and several MCU systems was implemented.Conclusion A low-cost,high-performance community-oriented health monitoring solution was realized,which can be easily applied to mobile monitoring at home.

Research and Development on Digital Temperature Recorder System of Vehicle-mounted Blood Bank Based on ATmega48 / 医疗卫生装备

Objective To research and develop a new type of temperature recorder system of vehicle-mounted blood bank which is used in the field training and combat. Methods Based on ATmega48 SCM as control core, the components including digital temperature recorder, LCD, buzzer and so on are used. Results The recorder can not only monitor temperature and display real-time, but also store the data in the recorder of the serial EEPROM (CAT24C64). Additionally, when the temperature exceeds the given range, it can be automatic alarm. Conclusion The temperature recorder with a short collection cycle, the record for a long time and high sensitivity, cost-effective, small size and easy to carry, etc., can be widely used in medicine, food, chemicals, electronic manufacturing, warehousing, logistics, as well as agriculture and other sectors.

Development of Long Pulse YAG Laser Treatment Machine / 医疗卫生装备

Objective To develop a laser treatment machine for the benign prostatic hyperplasia(BPH),which can both avoid the transurethral resection symptoms(TURS) and rapidly remove the big BPH.Methods The machine adopted a long plus laser with 80W average power and 1000W peak value power in order to rapidly vaporize the neoplasm.Because of its high power,short operation time and small thermal penetraction depth,it could avoid the post-operation edema of the organ is resulted from the concretion of traditional continuous-wavelength YAG laser.The control system based on AT89C51 dominated the laser power,and meanwhile,it monitored the process to protect the machine.It was connected with the Hospital Information System(HIS) via RS232.Results The chicken breast tissues were irradiated with the sample machine under water,and the groove irradiated by laser was 4mm in width and 2.5mm in depth with the irradiation speed of 5mm/s.The arbonation of tissue surface was slight and the thermal damage to the adjacent tissues was the minimal.Conclusion This machine can rapidly vaporize the neoplasm with the minimal thermal damage to the adjacent non-irradiated tissues.It is desirable for the treatment of big BPH.

Design of plasma sterilization equipment and process control using H2O2 in low temperature / 医疗卫生装备

Objective To develop the plasma sterilization using H2O2 in low temperature. Methods According to the principle of plasma sterilization, the working process of the plasma sterilization using H2O2 in low temperature and its flow chart were designed. The requirement for system design was summarized, on the basis of which the structure frame was built up. The station diagram of movement of the gates controlled by PLD was put out by analyzing the process of their moving. The MCU acted as the main controller of the whole system. The action flow chart of the MCU controlling the process of the system was also given out. Results The process control in plasma sterilization equipment using H2O2 in low temperature achieved the stable running and low cost. Conclusion It is proved that this plan is feasible in implementation.

Development of programming cardiac trigger apparatus and its application to myocardial contrast echocardiography / 医疗卫生装备

This paper introduces a programming cardiac trigger apparatus used for the study of quantitative measurement of myocardial blood flow with myocardial contrast echocardiography.The design of hardware circuit based on MCU and the scheme of software based on Keil C51 are mainly discussed.With stable and reliable working,this apparatus provides a kind of technical support for the study of quantitative measurement of myocardial blood flow with continuous intravenous injection of sonicated microbubbles.

The development of ultrasound Doppler error detection equipment / 医疗卫生装备

In the field of medical engineering, ultrasonic Doppler technology develops rapidly and gains wide application. MICS-51 is one of the main series of MCU family and has been widely used in China. In this paper, the ultrasound Doppler error detection equipment based on MCS-51 is introduced.