RÉSUMÉ
Acute myeloid leukemia (AML) with t(3;5)(q25;q34), belonging to AML with myelodysplasia related changes according to WHO classification in 2008, is a subtype of AML that is particularly rare in children. NPM1/MLF1 fusion gene produced as a result of t(3;5)(q25;q34) was cloned, however, the exact mechanism of its role in leukemogenesis has not been clarified. Although this cytogenetic abnormality is regarded as an intermediate risk factor, its clinical significance is controversial until now. More cases need to be reported and investigated, therefore we present a case of AML with t(3;5)(q25;q34) in a 14-year-old girl with literature review.
Sujet(s)
Adolescent , Enfant , Femelle , Humains , Aberrations des chromosomes , Classification , Clones cellulaires , Leucémie aigüe myéloïde , Facteurs de risqueRÉSUMÉ
Acute myeloid leukemia (AML) with t(3;5)(q25;q34), belonging to AML with myelodysplasia related changes according to WHO classification in 2008, is a subtype of AML that is particularly rare in children. NPM1/MLF1 fusion gene produced as a result of t(3;5)(q25;q34) was cloned, however, the exact mechanism of its role in leukemogenesis has not been clarified. Although this cytogenetic abnormality is regarded as an intermediate risk factor, its clinical significance is controversial until now. More cases need to be reported and investigated, therefore we present a case of AML with t(3;5)(q25;q34) in a 14-year-old girl with literature review.
Sujet(s)
Adolescent , Enfant , Femelle , Humains , Aberrations des chromosomes , Classification , Clones cellulaires , Leucémie aigüe myéloïde , Facteurs de risqueRÉSUMÉ
PURPOSE: Bilateral internuclear ophthalmoplegia (INO) has been reported mostly in bilateral medial longitudinal fasciculus (MLF) lesion. To report a case who presented with typical bilateral internuclear ophthalmoplegia (INO) with no brainstem lesion on brain MRI. METHODS: Case presentation. RESULTS: Seventy two year-old woman presented with bilateral marked adduction limitation and diplopia. Bilateral marked adduction limitation did not cross midline. Nystagmus occured in abducting eye. Elevation and depression were normal in duction. Transcranial doppler revealed moderated stenosis of right internal carotid artery and severe stenosis of left intracranial internal carotid artery. Brain MRI revealed focal old infarction of right corona radiata and circumscribed acute infarction at more upper level of corona radiata, however, no pathologic finding was identified in brainstem. Initial severe exotropia was improved to 30 PD exotropia in primary position. Adduction limitation was markedly improved 2 months later but bilateral horizontal nystagmus in abducting eye persisted
Sujet(s)
Femelle , Humains , Tronc cérébral , Encéphale , Artère carotide interne , Sténose pathologique , Dépression , Diplopie , Exotropie , Infarctus , Imagerie par résonance magnétique , Nystagmus pathologique , Troubles de la motilité oculaireRÉSUMÉ
Es inducing human spleen cells in 30 cases were studied. We found that Es could not only induce IFN-? from human spleen cells, but also IL-2 and LT. The mixed lymphokines containing IFN-?(3269.6?1634.4 U/ml), IL-2 (64.8?40.8 U/ml) and LT (54.4?44.6 U/ml) were induced by ES. Our study shows that the mixed lymphokines appeared to be cytotoxic to human SMMC-7721, SPC-3, HcLa, Jutkat arid Molt-4 cells lines at all levels, but it had no cytotoxic effect to normal cells (WISH cells).