Résumé
Malignant glomus tumor is an exceedingly rare neoplasm occurring in the soft tissues. Controversy exists over whether malignant glomus tumor is a true malignancy due to the rarity of metastasis, however, this neoplasm has been known to show relatively frequent metastasis and poor outcome. To improve the outcome of systemic therapy for malignant glomus tumor might be necessary, but the appropriate chemotherapy or radiotherapy has yet to be elucidated. We report a case of malignant glomus tumor with multiple pulmonary metastases treated with total surgical resection and adjuvant chemotherapy including doxorubicin and ifosfamide; however 7 months after completion of chemotherapy primary lung nodules increased. This case suggests that these chemotherapeutic agents are not effective for the management of malignant glomus tumor with metastasis.
Sujets)
Femelle , Humains , Traitement médicamenteux adjuvant , Doxorubicine , Traitement médicamenteux , Tumeur glomique , Ifosfamide , Poumon , Métastase tumorale , Radiothérapie , ÉpauleRésumé
Malignant glomus tumor is an exceedingly rare neoplasm occurring in the soft tissues. Controversy exists over whether malignant glomus tumor is a true malignancy due to the rarity of metastasis, however, this neoplasm has been known to show relatively frequent metastasis and poor outcome. To improve the outcome of systemic therapy for malignant glomus tumor might be necessary, but the appropriate chemotherapy or radiotherapy has yet to be elucidated. We report a case of malignant glomus tumor with multiple pulmonary metastases treated with total surgical resection and adjuvant chemotherapy including doxorubicin and ifosfamide; however 7 months after completion of chemotherapy primary lung nodules increased. This case suggests that these chemotherapeutic agents are not effective for the management of malignant glomus tumor with metastasis.
Sujets)
Femelle , Humains , Traitement médicamenteux adjuvant , Doxorubicine , Traitement médicamenteux , Tumeur glomique , Ifosfamide , Poumon , Métastase tumorale , Radiothérapie , ÉpauleRésumé
Glomus tumors are usually benign tumors that occur in the skin and soft tissues of the extremities. Visceral locations, such as stomach, intestines or lung, are extremely rare because glomus bodies are rare or absent in these organs. This report describes our experience in a 47-year-old woman diagnosed with a peritoneal malignant glomus tumor. This finding has not been previously reported.
Sujets)
Femelle , Humains , Adulte d'âge moyen , Tumeur glomique/anatomopathologie , Tumeurs du péritoine/anatomopathologie , Sarcomes , TomodensitométrieRésumé
Malignant glomus tumor, or glomangiosarcoma, is a very rare neoplasm that typically arises from a benign glomus tumor. Despite having the histological features of malignancy, these tumors usually do not metastasize. We report a case of malignant glomus tumor on the finger of an 18-year-old man. By histology, round to ovoid tumor cells showed a uniform appearance of round nuclei. Many mitotic figures and nuclear atypia were observed. Immunohistochemically, vimentin and alpha-smooth muscle actin showed intense staining. This case was considered to be a malignant glomus tumor. Thus, it was a glomangiosarcoma arising de novo.
Sujets)
Adolescent , Humains , Actines , Doigts , Tumeur glomique , Muscles , VimentineRésumé
Glomus tumors are uncommon soft tissue tumors which usually found in a subungual lesion of hand, producing pain. This uncommon tumors have been reported in other locations, including nasal cavity, stomach, mediastinum, heart, lung, and vagina etc. Especially, it was a very rare case found in an extradigital lesion of foot. Glomus tumors should not be ruled out for an extradigital mass lesion of foot and also any other locations. Although glomus tumors are generally considered a benign lesion, it should be considered that glomus tumors have also reported as a malignant type tumor, even the diagnosis based on histologic features not clinical one.
Sujets)
Diagnostic , Pied , Tumeur glomique , Main , Coeur , Poumon , Médiastin , Fosse nasale , Estomac , VaginRésumé
An extremely rare case of malignant glomus tumor originating in the superior mediastinum was evaluated immunohistochemically and ultrastructurally. A 78-year-old woman who had been suffering from dysphagia and dyspnea had poorly-defined soft tissue mass, 4.5 x 2.5cm, in the superior mediastinum with direct invasion into the esophagus, trachea, and bilateral thyroid glands. This case is believed to be unique in several respects. There were neither recognizable findings of benign glomus tumor nor sarcomatous areas, in contrast to the previously reported cases. A definite direct invasion into the surrounding organs was identified. We therefore interpreted this case as primary malignant glomus tumor, not as glomangiosarcoma arising in a benign glomus tumor.